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Hypertension, Statin Use Increased for Individuals Using TAF for PrEP
THURSDAY, Sept. 14, 2023 -- For individuals taking preexposure prophylaxis (PrEP) for preventing HIV infection, tenofovir alafenamide fumarate (TAF) use is associated with higher incident hypertension and statin initiation compared with tenofovir...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Racial Disparities Seen in Presentation of Frontotemporal Dementia
THURSDAY, Sept. 14, 2023 -- Racial disparities can be seen in dementia severity, functional impairment, and neuropsychiatric symptoms among patients with frontotemporal dementia (FTD), according to a study published online Sept. 11 in JAMA...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Prescribed Medical Cannabis Use Tied to Better Health-Related Quality of Life
THURSDAY, Sept. 14, 2023 -- There may be significant and clinically meaningful improvements in overall health-related quality of life (HRQoL) and fatigue in patients with chronic health conditions during the first three months of prescribed medical...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Home-Based Ovulation Monitoring Feasible for Timing Frozen-Thawed Embryo Transfer
THURSDAY, Sept. 14, 2023 -- Home-based monitoring of ovulation is noninferior to hospital-controlled monitoring to time frozen-thawed embryo transfer (FET) for pregnancy, according to a study published online Sept. 4 in The Lancet. Tjitske Zaat,...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Minimally Processed Red Meat Can Work in Weight Loss Diet With Diabetes
THURSDAY, Sept. 14, 2023 -- A normal-protein diet that excludes red meat and a high-protein diet that contains minimally processed lean beef are similarly effective at producing weight loss and improvements in glucose control among individuals with...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Interventions Can Increase Adjuvant Endocrine Treatment Adherence
THURSDAY, Sept. 14, 2023 -- Lowering medication costs and some psychosocial and reminder interventions show the most promise for promoting adjuvant endocrine therapy (AET) adherence in breast cancer survivors, according to a review published online...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Immune Response Not Inferior With Coadministration of COVID-19, Flu Shots
THURSDAY, Sept. 14, 2023 -- The immune response and occurrence of adverse events were similar for health care workers receiving coadministration of COVID-19 and influenza vaccines or COVID-19 vaccine alone, according to a study published online...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Factors Identified for Readmission Among Children With ARDS
THURSDAY, Sept. 14, 2023 -- Among hospitalized children with acute respiratory distress syndrome (ARDS) who survive to discharge, the presence or development of a chronic medical condition, tracheostomy placement during the admission, and...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Improvement Seen in Reproductive Hormone Levels With Keto Diet in PCOS
THURSDAY, Sept. 14, 2023 -- For women with polycystic ovary syndrome (PCOS), following a ketogenic diet is associated with significant improvement in reproductive hormone levels, according to research published online Sept. 7 in the Journal of the...
Source: Drugs.com - Pharma News - September 14, 2023 Category: Pharmaceuticals Source Type: news

Nose-to-Brain Delivery of Hesperidin Nanoparticles Loaded In-Situ Gel for Neuroprotective Action
CONCLUSION: This study showed the potential of HSP NPs to be an effective neuroprotective agent.PMID:37708993 | DOI:10.1016/j.pharma.2023.09.001
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Suraj Bamankar Vaishali Londhe Source Type: research

PLGA-based microspheres loaded with metformin hydrochloride: modified double emulsion method preparation, optimization, characterization, and in vitro evaluation
Ann Pharm Fr. 2023 Sep 12:S0003-4509(23)00105-0. doi: 10.1016/j.pharma.2023.09.002. Online ahead of print.ABSTRACTThe modified solvent removal method was used to encapsulate metformin hydrochloride (MH) within poly(lactic-co-glycolic acid) (PLGA) microspheres. The study investigated the effect of varying polymer concentrations on the loading and release of the drug from the microspheres. The encapsulation process involved using a double emulsion method, resulting in microspheres with particle diameters ranging from approximately 4.4 µm to 2.7 µm. The study achieved high encapsulation efficiencies, ranging from 81% to 90%...
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Priyanka Chauhan Himanshu Paliwal Chetan Singh Chauhan Ankit Paliwal Source Type: research

Charge variants of proposed biosimilar to Omalizumab: Isolation, purification and analysis by HPLC methods
In this study, biosimilar product of Xolair was expressed in mammalian cell culture process in laboratory to isolate charge variants (acidic, main peak and basic). Different charge variants were isolated from intermediate purified biosimilar product of Xolair. Isolated charge variants were purified with preparative cation exchange chromatography technique and characterized with different analytical tools includes size exclusion chromatography (SEC-HPLC) and cation exchange chromatography (CEX-HPLC). Purity of acidic, main peak and basic variants was 99.58%, 99.98% and 98.64% respectively as per SEC-HPLC and according to CE...
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Tarun Gupta Sriram Seshadri Source Type: research

Nose-to-Brain Delivery of Hesperidin Nanoparticles Loaded In-Situ Gel for Neuroprotective Action
CONCLUSION: This study showed the potential of HSP NPs to be an effective neuroprotective agent.PMID:37708993 | DOI:10.1016/j.pharma.2023.09.001
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Suraj Bamankar Vaishali Londhe Source Type: research

PLGA-based microspheres loaded with metformin hydrochloride: modified double emulsion method preparation, optimization, characterization, and in vitro evaluation
Ann Pharm Fr. 2023 Sep 12:S0003-4509(23)00105-0. doi: 10.1016/j.pharma.2023.09.002. Online ahead of print.ABSTRACTThe modified solvent removal method was used to encapsulate metformin hydrochloride (MH) within poly(lactic-co-glycolic acid) (PLGA) microspheres. The study investigated the effect of varying polymer concentrations on the loading and release of the drug from the microspheres. The encapsulation process involved using a double emulsion method, resulting in microspheres with particle diameters ranging from approximately 4.4 µm to 2.7 µm. The study achieved high encapsulation efficiencies, ranging from 81% to 90%...
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Priyanka Chauhan Himanshu Paliwal Chetan Singh Chauhan Ankit Paliwal Source Type: research

Charge variants of proposed biosimilar to Omalizumab: Isolation, purification and analysis by HPLC methods
In this study, biosimilar product of Xolair was expressed in mammalian cell culture process in laboratory to isolate charge variants (acidic, main peak and basic). Different charge variants were isolated from intermediate purified biosimilar product of Xolair. Isolated charge variants were purified with preparative cation exchange chromatography technique and characterized with different analytical tools includes size exclusion chromatography (SEC-HPLC) and cation exchange chromatography (CEX-HPLC). Purity of acidic, main peak and basic variants was 99.58%, 99.98% and 98.64% respectively as per SEC-HPLC and according to CE...
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Tarun Gupta Sriram Seshadri Source Type: research

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