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Exercise Training-Induced Modulation in Microenvironment of Rat Mammary Neoplasms
Int J Sports Med DOI: 10.1055/a-0660-0198Despite the importance attributed to exercise training in the breast cancer (BC) continuum, the underlying mechanisms modulating tumor behavior are unknown. We evaluated the effects of long-term moderate-exercise in the development of mammary tumors, and studied the microenvironment of infiltrative lesions, the amount of connective tissue, and balance between cellular proliferation/death.Fifty Sprague-Dawley rats, randomly assigned into four groups: two control groups (sedentary and exercised) and two models of BC groups (sedentary and exercised) induced by N-methyl-N-nitrosoureia (...
Source: International Journal of Sports Medicine - August 10, 2018 Category: Sports Medicine Authors: Figueira, Ana Cristina Corr êa Figueira, Mafalda Corr êa Silva, Carina Padr ão, Ana Oliveira, Paula Alexandra Ferreira, Rita Pinho Duarte, Jose Alberto Tags: Physiology & Biochemistry Source Type: research
Metastatic Cancer of the Thoracic and Lumbar Spine Presenting as Mid- and Low Back Pain in a Long Distance Runner
The purpose of this case study is to describe the presentation of a patient with persistent back pain and a history of carcinoma.
Source: Journal of Chiropractic Medicine - June 1, 2018 Category: Complementary Medicine Authors: Jeffrey P. Leri Tags: Topics in sports medicine Source Type: research
Nuclear Medicine and its promising applications in gynecological cancers.
Authors: Lioupis M, Syrmos NC
Abstract
Nuclear medicine is defined as: "the scientific and clinical discipline in which free radionuclides and radionuclide compounds, redistributed in vivo or in vitro by physical or chemical mechanisms, are used for diagnostic, therapeutic or investigative purposes". It seems that the above definition of Nuclear Medicine well includes the fact that Nuclear Medicine embraces into very important areas such as molecular imaging, cellular imaging and tissue imaging. Related to the interesting papers of Çerçi S. S. et al in HJNM, we may additionally state the following: During the las...
Source: Hellenic Journal of Nuclear Medicine - March 3, 2016 Category: Nuclear Medicine Tags: Hell J Nucl Med Source Type: research
Clinical implications of omics and systems medicine: focus on predictive and individualized treatment
Abstract
Many patients with common diseases do not respond to treatment. This is a key challenge to modern health care, which causes both suffering and enormous costs. One important reason for the lack of treatment response is that common diseases are associated with altered interactions between thousands of genes, in combinations that differ between subgroups of patients who do or do not respond to a given treatment. Such subgroups, or even distinct disease entities, have been described recently in asthma, diabetes, autoimmune diseases and cancer. High‐throughput techniques (omics) allow identification and characterizat...
Source: Journal of Internal Medicine - August 19, 2015 Category: Internal Medicine Authors: M. Benson Tags: Review Source Type: research
Prognostic Value of Functional Assessment of Cancer Therapy-General (FACT-G) in Advanced Non-Small-Cell Lung Cancer Treated with Korean Medicine.
Conclusion: The FACT-G total score and PWB score as HRQoL measurements were significant prognostic factors for survival in advanced NSCLC patients treated with Korean medicine. This finding implies that the FACT-G can be used in clinical practice as a predictor of survival in patients with advanced NSCLC.
PMID: 32454853 [PubMed - as supplied by publisher]
Source: Evidence-based Complementary and Alternative Medicine - May 27, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Application of organoid culture from HPV18 ‐positive small cell carcinoma of the uterine cervix for precision medicine
ConclusionIn this study, we confirmed two strategies for identifying therapeutic targets of HPV-derived SCCC, WES for identifying pathogenic variants and RNA sequencing for identifying HPV integration sites. Organoid culture is an effective tool for unveiling the oncogenic process of rare tumors and can be a breakthrough for the development of precision medicine for patients with HPV-positive SCCC.
Source: Cancer Medicine - January 24, 2023 Category: Cancer & Oncology Authors: Misako Kusakabe,
Ayumi Taguchi,
Michihiro Tanikawa,
Daisuke Hoshi,
Saki Tsuchimochi,
Xi Qian,
Yusuke Toyohara,
Akira Kawata,
Ryota Wagatsuma,
Kohei Yamaguchi,
Yoko Yamamoto,
Masako Ikemura,
Kenbun Sone,
Mayuyo Mori ‐Uchino,
Hiroko Matsunag Tags: RESEARCH ARTICLE Source Type: research
Precision medicine and precision therapeutics: hedgehog signaling pathway, basal cell carcinoma and beyond.
Authors: Mohan SV, Chang AL
Abstract
Precision medicine and precision therapeutics is currently in its infancy with tremendous potential to improve patient care by better identifying individuals at risk for skin cancer and predict tumor responses to treatment. This review focuses on the Hedgehog signaling pathway, its critical role in the pathogenesis of basal cell carcinoma, and the emergence of targeted treatments for advanced basal cell carcinoma. Opportunities to utilize precision medicine are outlined, such as molecular profiling to predict basal cell carcinoma response to targeted therapy and to inform therap...
Source: Seminars in Cutaneous Medicine and Surgery - November 14, 2014 Category: Dermatology Tags: Semin Cutan Med Surg Source Type: research
Prospects and challenges of circulating tumor DNA in precision medicine of hepatocellular carcinoma
AbstractThe growing role of precision medicine in hepatocellular carcinoma (HCC) is expected to ameliorate the poor prognosis and high mortality of this highly malignant disease; however, it is faced with challenges such as the low frequency of tissue biopsy. Hence, attention is turning to the circulating tumor DNA (ctDNA), an important component of liquid biopsy. Obtaining molecular information about cancer from blood provides a good prospect in precision oncology including molecular diagnosis, molecular classification, targeted therapy, personalized decision making, and detection of drug-resistance mutations. However, in...
Source: Clinical and Experimental Medicine - March 31, 2020 Category: Research Source Type: research
Comparison of the effect of traditional Chinese medicine injection combined with chemotherapy and chemotherapy alone on the prognosis, quality of life and immune function in patients with ovarian carcinoma: A protocol for systematic review and network meta-analysis
Conclusions:
Evidence-based medicine supports the efficacy and safety of TCMJ combined with chemotherapy for the treatment of ovarian carcinoma, which is better than that of chemotherapy alone.
Ethics and dissemination:
Ethical approval was not required for this study. The systematic review will be published in a peer-reviewed journal, presented at conferences, and shared on social media platforms.
OSF REGISTRATION NUMBER:
DOI 10.17605/OSF.IO/P93VJ.
Source: Medicine - October 15, 2021 Category: Internal Medicine Tags: Research Article: Study Protocol Systematic Review Source Type: research
Effect of Combination of Traditional Chinese Medicine with Western Medicine on Endometrial Carcinoma and Its Influence on Ultrasound, MRI, Tumor Markers HE4 and CA125
CONCLUSION: Radix Astragali injection combined with megestrol acetate tablets has obvious therapeutic effects against endometrial cancer. Through vaginal ultrasonography and MRI, it can significantly improve the size, shape, and blood flow signals of patients' lesions, reduce the level of serum inflammatory factors and tumor markers HE4 and CA125, reduce the incidence of toxic and side reactions, improve the patient's immunity, improve the patient's condition significantly, and prolong the survival time of patients.PMID:34899952 | PMC:PMC8660184 | DOI:10.1155/2021/6053406
Source: Evidence-based Complementary and Alternative Medicine - December 13, 2021 Category: Complementary Medicine Authors: Xia Gao Qiuying Li Yanwen Qu Jinzhi Zhang Yougang Xing Shichun Li Source Type: research
The Diagnostic Value of Serum Ang, VEGF, and CRP Combined with the Chinese Medicine Antitumor Formula in the Treatment of Advanced Renal Carcinoma
CONCLUSION: The combined detection of serum Ang, VEGF, and CRP has high diagnostic value for patients with advanced renal cancer treated with Chinese medicine antitumor formula.PMID:34950214 | PMC:PMC8692006 | DOI:10.1155/2021/5189069
Source: Evidence-based Complementary and Alternative Medicine - December 24, 2021 Category: Complementary Medicine Authors: Nana Dong Shengmin Zhang Shuangjun Zhang Qiongqiong Zhao Donghua Zhang Feng Chen Source Type: research
Roles of Kampo medicine in chemotherapy ‐related adverse events
ConclusionsThe application of Kampo therapy in cancer supportive care is considered to be indispensable not only for improving treatment outcomes, but also for improving the quality of cancer treatments and the QOL of cancer patients in the latest treatment of cancer.
Source: Traditional and Kampo Medicine - March 22, 2023 Category: Complementary Medicine Authors: Takamasa Nishiuchi,
Kotone Nomura,
Yu Suezawa Tags: REVIEW Source Type: research
