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Cancer: Leukemia

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Total 9798 results found since Jan 2013.

Acute myeloid leukemia presenting as back pain in a 12-year-old boy.
PMID: 24412889 [PubMed - in process]
Source: Current Sports Medicine Reports - January 1, 2014 Category: Sports Medicine Authors: Turner C, Grady M Tags: Curr Sports Med Rep Source Type: research

Myokines: a descriptive review.
Authors: Barbalho SM, Vieira Prado Neto E, de Alvares Goulart R, Bechara MD, Federighi Baisi Chagas E, Audi M, Guissoni Campos LM, Landgraf Guiger E, Leoni Buchain R, Buchain DV, Cressoni Araujo A Abstract In the last years, scientists have shown that skeletal muscle is not a pure locomotor unit or responsible for propulsion and posture. Skeletal muscle encompasses one of the major organs of the body (constituting about 40% of the body mass in non-obese men). It regulates energy and metabolic processes and is now recognized as an organ capable of producing molecules with vital functions. These molecules are termed ...
Source: Journal of Sports Medicine and Physical Fitness - June 28, 2020 Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research

Non-occupational physical activity and risk of cardiovascular disease, cancer and mortality outcomes: a dose-response meta-analysis of large prospective studies
CONCLUSIONS: Inverse non-linear dose-response associations suggest substantial protection against a range of chronic disease outcomes from small increases in non-occupational physical activity in inactive adults. PROSPERO registration number CRD42018095481.PMID:36854652 | DOI:10.1136/bjsports-2022-105669
Source: British Journal of Sports Medicine - February 28, 2023 Category: Sports Medicine Authors: Leandro Garcia Matthew Pearce Ali Abbas Alexander Mok Tessa Strain Sara Ali Alessio Crippa Paddy C Dempsey Rajna Golubic Paul Kelly Yvonne Laird Eoin McNamara Samuel Moore Thiago Herick de Sa Andrea D Smith Katrien Wijndaele James Woodcock Soren Brage Source Type: research

Fatal Intracerebral Hemorrhage During “Muay Thai” in a 21-Year-Old Man With Undiagnosed Acute Myeloid Leukemia: Spontaneous or Posttraumatic Hemorrhage?
Acute myeloid leukemia (AML) is characterized by the rapid growth of abnormal white blood cells in the bone marrow that interferes with the production of normal blood cells. This disease is burdened by a high risk of bleeding complications involving central nervous system hemorrhages, purpura, gingival bleeding, and gastrointestinal bleeding. In this article, the authors report a case of a fatal intracerebral hemorrhage in a 21-year-old man who was affected by an undiagnosed AML. The subject practiced a combat sport (Muay Thai), and 2 days before his last training, he was involved in a fight where the aggressor punched him...
Source: The American Journal of Forensic Medicine and Pathology - August 14, 2020 Category: Forensic Medicine Tags: Case Reports Source Type: research

Precision Medicine in Myelodysplastic Syndromes and Leukemias: Lessons from Sequential Mutations.
Abstract Precision medicine can be simply defined as the identification of personalized treatment that matches patient-specific clinical and genomic characteristics. Since the completion of the Human Genome Project in 2003, significant advances have been made in our understanding of the genetic makeup of diseases, especially cancers. The identification of somatic mutations that can drive cancer has led to the development of therapies that specifically target the abnormal proteins derived from these mutations. This has led to a paradigm shift in our treatment methodology. Although some success has been achieved in ...
Source: Annual Review of Medicine - September 6, 2016 Category: Journals (General) Authors: Nazha A, Sekeres MA Tags: Annu Rev Med Source Type: research

A case of chemotherapy-induced congestive heart failure successfully treated with Chinese herbal medicine.
CONCLUSIONS: In this case, anthracycline-induced cardiotoxicity resolved slowly following the administration of modified ZGCT. It is suggested that the CHM formula has a protective effect on the progression of CHF secondary to the use of anthracyclines in pediatric cancer. Further studies to determine the mechanism and clinical trials are warranted. PMID: 25847563 [PubMed - in process]
Source: Complementary Therapies in Medicine - April 1, 2015 Category: Complementary Medicine Authors: Wu BY, Liu CT, Chen SY, Tsai MY Tags: Complement Ther Med Source Type: research

Fine-tuning patient-derived xenograft models for precision medicine approaches in leukemia
Many leukemias are characterized by well-known mutations that drive oncogenesis. Mice engineered with these mutations provide a foundation for understanding leukemogenesis and identifying therapies. However, data from whole genome studies provide evidence that malignancies are characterized by multiple genetic alterations that vary between patients, as well as inherited genetic variation that can also contribute to oncogenesis. Improved outcomes will require precision medicine approaches–targeted therapies tailored to malignancies in each patient. Preclinical models that reflect the range of mutations and the genetic...
Source: Journal of Investigative Medicine - February 24, 2016 Category: Research Authors: Francis, O. L., Milford, T.-A. M., Beldiman, C., Payne, K. J. Tags: Experimental biology symposia Source Type: research

Integration of Chinese Herbal Medicine Therapy Improves Survival of Patients With Chronic Lymphocytic Leukemia: A Nationwide Population-Based Cohort Study
Abstract: Utilization of Chinese Medicine (CM) is not uncommon in patients with chronic lymphocytic leukemia (CLL). However, the current knowledge of the usage and efficacy of CM among CLL patients is limited. The aim of this study was to determine the impact of integrative Chinese Herbal Medicine (CHM) on the disease course of CLL and ascertain the herbal products most commonly prescribed to patients with CLL. A Taiwanese nationwide population-based study involving the use of Western medicine and CM services provided by the National Health Insurance (NHI) was conducted. An NHI Research Database-based cohort study was pe...
Source: Medicine - May 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The Effectiveness of Traditional Chinese Medicine in Treating Patients with Leukemia.
This study analyzes the status of TCM utilization in Taiwan, in both pediatric and adult patients with leukemia. A retrospective cohort study was conducted using population-based National Health Insurance Research Database of Registry of Catastrophic Illness, involving patient data from 2001 to 2010 and follow-up data through 2011. The effectiveness of TCM use was evaluated. Relevant sociodemographic data showed that both pediatric and adult patients who were TCM users one year prior to leukemia diagnosis were more likely to utilize TCM services for cancer therapy. A greater part of medical expenditure of TCM users was low...
Source: Evidence-based Complementary and Alternative Medicine - November 18, 2016 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Systems medicine paves the way for improved treatment for leukemia patients
(University of Helsinki) A new individualized systems medicine strategy, developed at the Institute for Molecular Medicine Finland FIMM and the Helsinki University Central Hospital, enables a selection of potentially effective cancer therapies for individual patients. The promising results achieved by applying this strategy to chemoresistant adult acute myeloid leukemia patients have been recently published in the Cancer Discovery journal.
Source: EurekAlert! - Medicine and Health - December 12, 2013 Category: Global & Universal Source Type: news

Adjunctive Chinese Herbal Medicine therapy improves survival of patients with chronic myeloid leukemia: a nationwide population‐based cohort study
Abstract Despite good clinical results of current drugs, a good reason still exists to search for additional therapies for the management of Chronic Myeloid Leukemia (CML). Chinese Herbal Medicine (CHM) has thus far been overlooked by researchers and no data exists on the subject. We studied the impact of adjunctive CHM on the disease course of CML, using mortality as the major outcome measurement. We used the Taiwanese National Health Insurance Research Database to perform a nationwide population‐based cohort study. Our study included CML patients diagnosed between 2000 and 2010. We matched groups according to age, sex,...
Source: Cancer Medicine - January 15, 2016 Category: Cancer & Oncology Authors: Tom Fleischer, Tung‐Ti Chang, Jen‐Huai Chiang, Ching‐Mao Chang, Ching‐Yun Hsieh, Hung‐Rong Yen Tags: Original Research Source Type: research

Long noncoding RNAs to predict survival in acute myeloid leukemia: a step toward personalized medicine?
Authors: Bhatnagar B, Garzon R PMID: 27548737 [PubMed - as supplied by publisher]
Source: Future Medicine: Biomarkers in Medicine - August 23, 2016 Category: Internal Medicine Tags: Biomark Med Source Type: research

Influences of Realgar-Indigo naturalis, A Traditional Chinese Medicine Formula, on the Main CYP450 Activities in Rats Using a Cocktail Method.
In this study, Wistar rats were administered intragastric RIF and realgar for 14 days; mixed probe drugs were injected into rats by caudal vein. Through analyzing the pharmacokinetic parameter of mixed probe drugs in rats, we can calculate the CYPs activities. The results showed that RIF could inhibit CYP1A2 enzyme activity and induce CYP2C11 enzyme activity significantly. Interestingly, in realgar high dosage group, CYP3A1/2 enzyme activity was inhibited significantly, and different dosage of realgar manifested a good dose-dependent manner. The RIF results indicated that drug coadministrated with RIF may need to be paid a...
Source: Evidence-based Complementary and Alternative Medicine - April 21, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Adult Stem Cells and Medicine.
Authors: Bozdağ SC, Yüksel MK, Demirer T Abstract Stem cells can be either totipotent, pluripotent, multipotent or unipotent. Totipotent cells have the capability to produce all cell types of the developing organism, including both embryonic and extraembryonic tissues. The Hematopoietic Stem Cells (HSC) are the first defined adult stem cells (ASC) that give rise to all blood cells and immune system. Use of HSCs for treatment of hematologic malignancies, which is also called bone marrow (BM) transplantation or peripheral blood stem cells (PBSC) transplantation is the pioneer of cellular therapy and translational r...
Source: Advances in Experimental Medicine and Biology - March 22, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Decoction of Chinese Herbal Medicine Fuzheng Kang-Ai Induces Lung Cancer Cell Apoptosis via STAT3/Bcl-2/Caspase-3 Pathway.
This study unveils potential novel molecular mechanism by which FZKA controls growth of human lung cancer cells. PMID: 30046347 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - July 27, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research