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Total 8572 results found since Jan 2013.

Treatment of severe rash caused by crizotinib with both traditional Chinese medicine and Western medicine: Two case reports and literature review
Rationale: Lung adenocarcinoma is the most common pathologic pattern of lung cancer. During the past decades, a number of targeted agents have been explored to treat advanced lung adenocarcinoma. Recently, Crizotinib, the antagonist of anaplastic lymphoma kinase (ALK), has been widely used in ALK-rearranged lung cancer treatment. Crizotinib is generally well tolerated while its most frequent adverse events include visual disorders, gastrointestinal disturbances, cardiac and endocrine abnormalities. Rash caused by crizotinib is rarely seen, and there are few case reports of severe rash caused by crizotinib. Patient conce...
Source: Medicine - November 1, 2018 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Pancreatic Cancer Subtypes: A Roadmap for Precision Medicine.
Authors: Torres C, Grippo PJ Abstract Pancreatic ductal adenocarcinoma (PDAC) is projected to become the second cause of cancer-related deaths by 2020. Although it has traditionally been approached as one disease, accumulated evidences point to the clinical heterogeneity of this disease which translates into disparity in outcomes between patients. Much emphasis has been put into patient classification introducing a platform for more tailored therapies. In the last ten years, there have been important advances in the understanding of the molecular pathogenesis of PDAC, which has culminated with a comprehensive integ...
Source: Annals of Medicine - March 16, 2018 Category: Internal Medicine Tags: Ann Med Source Type: research

Future of Theranostics: An Outlook on Precision Oncology in Nuclear Medicine
Molecular alterations in malignant disease result in the expression or upregulations of various targets that can be used for imaging and treatment with radiopharmaceuticals. This theranostic principle has acquired greater importance in personalized medicine in recent years, particularly in oncology, where advanced tumors can be treated effectively with low side effects. Since the pioneering use of 131I in differentiated thyroid cancer in the 1940s, remarkable achievements in nuclear medicine endoradiotherapy have been demonstrated, mainly in the treatment of neuroendocrine neoplasms by using 177Lu-labeled somatostatin anal...
Source: Journal of Nuclear Medicine - September 2, 2019 Category: Nuclear Medicine Authors: Langbein, T., Weber, W. A., Eiber, M. Tags: Supplement Source Type: research

Multidisciplinary and Comprehensive Chinese Medicine for Advanced Non-Small Cell Lung Cancer Patients: A Retrospective Study of 855 Cases
ConclusionsFemale patients have lower progression risk and better prognoses than male patients, younger patients have higher progression risk but better long-term prognoses than the elderlys, and patients with lower performance status scores are at lower risk for progression and have better prognoses. Comprehensive CM treatments could significantly reduce progression risk, improve prognosis, and prolong survival time for patients with advanced NSCLC. This treatment mode offers additional advantages over supportive care alone.
Source: Chinese Journal of Integrative Medicine - September 1, 2020 Category: Internal Medicine Source Type: research

Multiscale heterogeneity in gastric adenocarcinoma evolution is an obstacle to precision medicine
ConclusionsNeutral and non-neutral somatic evolution shape the mutational landscape in GC along its lateral expansions. It leads to complex spatial intratumoral heterogeneity, where lymph node metastases may stem from different areas of the primary tumor, synchronously. Our findings may have profound effects on future patient management. They illustrate the risk of mis-interpreting tumor genetics based on single-sample analysis and open new avenues for an evolutionary classification of GC, i.e., the discovery of distinct evolutionary trajectories which can be utilized for precision medicine.
Source: Genome Medicine - November 8, 2021 Category: Genetics & Stem Cells Source Type: research

Traditional Chinese Medicine Syndromes are Associated with Driver Gene Mutations and Clinical Characteristics in Patients with Lung Adenocarcinoma
This study aimed to investigate the associations between traditional Chinese medicine (TCM) syndromes and driver gene mutations as well as the clinical characteristics of patients with lung adenocarcinoma. We performed a cross-sectional study in patients with lung adenocarcinoma between June 2020 and October 2021. The patient characteristics, such as age, sex, smoking history, clinical stage, metastasis, driver gene mutations, and the type of traditional Chinese medicine syndrome/element, were collected. The associations between each TCM syndrome and sex, smoking history, clinical stage, metastasis, and driver gene mutatio...
Source: Evidence-based Complementary and Alternative Medicine - October 17, 2022 Category: Complementary Medicine Authors: Jili Yang Haiyan Lu Niancai Jing Bo Wang Huanyu Guo Shoukun Sun Yue Zhang Source Type: research

Molecular profiling in non-small cell lung cancer: a step toward personalized medicine.
CONCLUSIONS: There are multiple mechanisms involved in the pathogenesis of lung cancer, which operate in parallel and involve pathways of activation and inhibition of various cellular events. Further research is essential to characterize the histologic and mutational profiles of lung carcinomas, which will ultimately translate into improved and more personalized therapeutic management of patients with lung cancer. PMID: 23544937 [PubMed - in process]
Source: Archives of Pathology and Laboratory Medicine - April 1, 2013 Category: Laboratory Medicine Authors: Raparia K, Villa C, DeCamp MM, Patel JD, Mehta MP Tags: Arch Pathol Lab Med Source Type: research

Editors' Choice Precision medicine in a dish
Pancreatic ductal adenocarcinoma patient–derived organoids might predict treatment response and precision medicine for cancer patients.
Source: Science Translational Medicine - June 13, 2018 Category: Biomedical Science Authors: Lujambio, A. Tags: Editors ' Choice Source Type: research

Investigate the mechanisms of Chinese medicine Fuzhengkangai towards EGFR mutation-positive lung adenocarcinomas by network pharmacology
Chinese traditional herbal medicine Fuzhengkangai (FZKA) formulation combination with gefitinib can overcome drug resistance and improve the prognosis of lung adenocarcinoma patients. However, the pharmacologi...
Source: BMC Complementary and Alternative Medicine - November 6, 2018 Category: Complementary Medicine Authors: Zhitong Bing, Zhiyuan Cheng, Danfeng Shi, Xinkui Liu, Jinhui Tian, Xiaojun Yao, Jingyun Zhang, Yongfeng Wang and Kehu Yang Tags: Research article Source Type: research

Alternative medicine: therapeutic effects on gastric original signet ring carcinoma via ascorbate and combination with sodium alpha lipoate
Gastric signet ring cell carcinoma (SRCC) is an aggressive gastric adenocarcinoma with a poor prognosis when diagnosed at an advanced stage. As alternative medicine, two natural supplements (ascorbate (AA) and...
Source: BMC Complementary and Alternative Medicine - March 7, 2022 Category: Complementary Medicine Authors: Weiyu Chen, Lingyun Xu, Edwin Chang, Gayatri Gowrishankar, Katherine W. Ferrara and Sanjiv Sam Gambhir Tags: Research Source Type: research

Factors Influencing Exercise Following Pancreatic Tumor Resection.
CONCLUSIONS: Less than one-quarter of participants exercised sufficiently to meet national exercise guidelines following pancreatectomy. To maximize exercise and related benefits, interventions should help survivors increase intrinsic motivation and overcome barriers to exercise. PMID: 32886288 [PubMed - as supplied by publisher]
Source: Ann Oncol - September 3, 2020 Category: Cancer & Oncology Authors: Parker NH, Basen-Engquist K, Rubin ML, Li Y, Prakash L, Ngo-Huang A, Gorzelitz J, Ikoma N, Lee JE, Katz MHG Tags: Ann Surg Oncol Source Type: research

Cancers, Vol. 14, Pages 3674: Precision Medicine of Hepatobiliary and Pancreatic Cancers: Focusing on Clinical Trial Outcomes
usawa Tumor-agnostic precision medicine employing comprehensive genome profiling (CGP) and using next-generation sequencing (NGS) has been progressing recently. This review focuses on precision medicine for advanced unresectable hepatobiliary and pancreatic cancers. In this paper, for biliary tract cancer (BTC), therapies that target several regulators of cancer cell growth, including isocitrate dehydrogenase 1 (IDH1), fibroblast growth factor receptor 2 (FGFR2) fusion, proto-oncogene B-Raf (BRAF), and human epidermal growth factor receptor 2 (HER2) alterations, are reviewed. For pancreatic ductal adenocarcinoma (PDAC)...
Source: Cancers - July 28, 2022 Category: Cancer & Oncology Authors: Takehiko Tsumura Keitaro Doi Hiroyuki Marusawa Tags: Review Source Type: research

Cancers, Vol. 13, Pages 2427: Does the Microenvironment Hold the Hidden Key for Functional Precision Medicine in Pancreatic Cancer?
e A. Phillips Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal cancers and no significant improvement in patient survival has been seen in the past three decades. Treatment options are limited and selection of chemotherapy in the clinic is usually based on the performance status of a patient rather than the biology of their disease. In recent years, research has attempted to unlock a personalised treatment strategy by identifying actionable molecular targets in tumour cells or using preclinical models to predict the effectiveness of chemotherapy. However, these approaches rely on the biology of PDAC tu...
Source: Cancers - May 17, 2021 Category: Cancer & Oncology Authors: John Kokkinos Anya Jensen George Sharbeen Joshua A. McCarroll David Goldstein Koroush S. Haghighi Phoebe A. Phillips Tags: Review Source Type: research

Abstract LB-36: Chemotherapy testing of primary human ovarian cancers in an ex vivo 3D culture platform: A novel method of phenotypic profiling for clinical trial selection and personalized medicine
We describe optimized methods of ex vivo 3D (EV3D™) culture and testing of primary human ovarian cancer for personalized medicine. Our hypothesis was that 3D spheroid cultures from primary human tumors would demonstrate unique growth parameters and distinct ex vivo testing responses compared to traditional 2D cultures. Materials relative and absolute IC50s and total percent inhibition were used for ranking compounds. Results: Median subject age was 63(29-82), majority of which had advanced stage adenocarcinomas. Carboplatin 2014 Apr 5-9; San Diego, CA. Philadelphia (PA): AACR; Cancer Res 2014;74(19 Suppl):Abstract nr LB-...
Source: Cancer Research - September 30, 2014 Category: Cancer & Oncology Authors: Shuford, S., Widener, R., Cheluvaraju, C., Desrochers, T., mattingly, c., Puls, L., gevaert, m., Orr, D., Crosswell, H. E. Tags: Tumor Biology Source Type: research