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The Effect of Aerobic Exercise and Macrothele raven Venom on Tumor-bearing Mice
In this study, we examined the antitumor effect of Macrothele raven venom in combination with exercise on tumor-bearing mice. Our results demonstrate that aerobic exercise in combination with venom administered at different doses was much more effective in a mouse H22 hepatoma model compared to separate administration of the 2 treatments. The underlying mechanism of this effect may be related to the expression of various tumor suppressor factors.[...]© Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents  |  Abstract  |  Full text
Source: International Journal of Sports Medicine - September 25, 2014 Category: Sports Medicine Authors: Sheng, Z. J.Qin, C. J.Wei, C. W.Miao, L. C.Hua, Z. G.Rui, C.Lin, L.Cai, W. M. Tags: Physiology & Biochemistry Source Type: research

Clinical implications of omics and systems medicine: focus on predictive and individualized treatment
Abstract Many patients with common diseases do not respond to treatment. This is a key challenge to modern health care, which causes both suffering and enormous costs. One important reason for the lack of treatment response is that common diseases are associated with altered interactions between thousands of genes, in combinations that differ between subgroups of patients who do or do not respond to a given treatment. Such subgroups, or even distinct disease entities, have been described recently in asthma, diabetes, autoimmune diseases and cancer. High‐throughput techniques (omics) allow identification and characterizat...
Source: Journal of Internal Medicine - August 19, 2015 Category: Internal Medicine Authors: M. Benson Tags: Review Source Type: research

Prospects and challenges of circulating tumor DNA in precision medicine of hepatocellular carcinoma
AbstractThe growing role of precision medicine in hepatocellular carcinoma (HCC) is expected to ameliorate the poor prognosis and high mortality of this highly malignant disease; however, it is faced with challenges such as the low frequency of tissue biopsy. Hence, attention is turning to the circulating tumor DNA (ctDNA), an important component of liquid biopsy. Obtaining molecular information about cancer from blood provides a good prospect in precision oncology including molecular diagnosis, molecular classification, targeted therapy, personalized decision making, and detection of drug-resistance mutations. However, in...
Source: Clinical and Experimental Medicine - March 31, 2020 Category: Research Source Type: research

Effect of Combination of Traditional Chinese Medicine with Western Medicine on Endometrial Carcinoma and Its Influence on Ultrasound, MRI, Tumor Markers HE4 and CA125
CONCLUSION: Radix Astragali injection combined with megestrol acetate tablets has obvious therapeutic effects against endometrial cancer. Through vaginal ultrasonography and MRI, it can significantly improve the size, shape, and blood flow signals of patients' lesions, reduce the level of serum inflammatory factors and tumor markers HE4 and CA125, reduce the incidence of toxic and side reactions, improve the patient's immunity, improve the patient's condition significantly, and prolong the survival time of patients.PMID:34899952 | PMC:PMC8660184 | DOI:10.1155/2021/6053406
Source: Evidence-based Complementary and Alternative Medicine - December 13, 2021 Category: Complementary Medicine Authors: Xia Gao Qiuying Li Yanwen Qu Jinzhi Zhang Yougang Xing Shichun Li Source Type: research

Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo
Conclusion Our studies suggest that the use of TCM cytotoxic genes is a useful therapeutic strategy for treating human cancers in general, and liver tumors in particular.
Source: Journal of Integrative Medicine - November 28, 2014 Category: Complementary Medicine Source Type: research

Chinese medicine herbal treatment based on syndrome differentiation improves the overall survival of patients with unresectable hepatocellular carcinoma
Conclusions CM herbs based on syndrome differentiation have positive effects on survival of patients with unresectable HCC. Furthermore, combination therapy of CM and WM are recommended in HCC treatment.
Source: Chinese Journal of Integrative Medicine - December 23, 2014 Category: Internal Medicine Source Type: research

Associations between prescribed Chinese herbal medicine and risk of hepatocellular carcinoma in patients with chronic hepatitis B: a nationwide population-based cohort study
Conclusions The use of CHM was associated with a significantly reduced HCC risk in patients with CHB, which supports the integration of TCM with CHM into clinical practice to influence a favourable prognosis.
Source: BMJ Open - January 24, 2017 Category: Journals (General) Authors: Tsai, T.-Y., Livneh, H., Hung, T.-H., Lin, I. -H., Lu, M.-C., Yeh, C.-C. Tags: Open access, Complementary medicine, Gastroenterology and hepatology Research Source Type: research

Add-On Therapy with Traditional Chinese Medicine Improves Outcomes and Reduces Adverse Events in Hepatocellular Carcinoma: A Meta-Analysis of Randomized Controlled Trials.
CONCLUSION: Add-on therapy with TCM could improve overall survival, increase clinical tumor responses, lead to better QOL, and reduce adverse events in hepatocellular carcinoma. PMID: 28680448 [PubMed - in process]
Source: Evidence-based Complementary and Alternative Medicine - July 7, 2017 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Chinese Medicine, Jiedu Recipe, Inhibits the Epithelial Mesenchymal Transition of Hepatocellular Carcinoma via the Regulation of Smad2/3 Dependent and Independent Pathways.
In conclusion, JR inhibits liver cancer cells migration and invasion through epithelial mesenchymal transition (EMT) inhibition via Smad2/3 dependent and independent pathways, suggesting it is an effective therapeutic strategy against HCC metastasis. PMID: 30174709 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - September 5, 2018 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Chinese herbal medicine reduces acute hepatitis exacerbation in patients with hepatitis B virus infection: A case-control study in Taiwan.
CONCLUSION: These findings highlight that the use of CHM was associated with a significantly reduced risk of acute exacerbation of hepatitis and subsequent cirrhosis and hepatoma in patients with HBV. Future research could further explore the benefit of CHM therapies for treatment of acute hepatitis exacerbation. PMID: 30670249 [PubMed - in process]
Source: Complementary Therapies in Medicine - January 25, 2019 Category: Complementary Medicine Authors: Chen WL, Lin CH, Huang CC, Tsai CI Tags: Complement Ther Med Source Type: research

Chinese Herbal Medicine (Chaihu-Huaji Decoction) Alleviates Postembolization Syndrome following Transcatheter Arterial Chemoembolization and Improves Survival in Unresectable Hepatocellular Cancer: A Retrospective Study.
Conclusion: Chaihu-huaji decoction may prevent adverse events after TACE and prolong overall survival of unresectable HCC patients when combined with TACE. PMID: 30854013 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - March 14, 2019 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Using Traditional Chinese Medicine to Treat Hepatocellular Carcinoma by Targeting Tumor Immunity.
Authors: Jia W, Wang L Abstract As the leading cause of cancer-related death, hepatocellular carcinoma (HCC) threatens human health and limited treatments are available to cure the disease efficiently and effectively. The particularly immunotolerant environment of the liver lowers the efficacy of current therapies in patients with advanced HCC. Traditional Chinese medicine (TCM) is gathering increasing interest due to the immunoregulatory properties of certain compounds. In advanced HCC, TCM can restore immunosurveillance to promote antitumor effects in several ways, including the upregulation of immunostimulatory ...
Source: Evidence-based Complementary and Alternative Medicine - July 2, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

Determining the Traditional Chinese Medicine (TCM) Syndrome with the Best Prognosis of HBV-Related HCC and Exploring the Related Mechanism Using Network Pharmacology
CONCLUSION: We propose a new research method of "prognosis of TCM syndromes-KCMMs-network pharmacology" to reveal the prognostic value of TCM syndromes and the potential mechanism by which TCM syndromes affect prognosis.PMID:34306165 | PMC:PMC8263254 | DOI:10.1155/2021/9991533
Source: Evidence-based Complementary and Alternative Medicine - July 26, 2021 Category: Complementary Medicine Authors: Zhulin Wu Chunshan Wei Lianan Wang Li He Source Type: research