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Source: Molecular Medicine Reports

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Total 11954 results found since Jan 2013.

Mechanism of herbal medicine on hypertensive nephropathy (Review)
Mol Med Rep. 2021 Apr;23(4):1. doi: 10.3892/mmr.2021.11873. Epub 2021 Feb 4.ABSTRACTHypertensive nephropathy is the most common complication of hypertension, and is one of the main causes of end‑stage renal disease (ESRD) in numerous countries. The basic pathological feature of hypertensive nephropathy is arteriolosclerosis followed by renal parenchymal damage. The etiology of this disease is complex, and its pathogenesis is mainly associated with renal hemodynamic changes and vascular remodeling. Despite the increased knowledge on the pathogenesis of hypertensive nephropathy, the current clinical treatment methods are s...
Source: Molecular Medicine Reports - February 4, 2021 Category: Molecular Biology Authors: Zhaocheng Dong Haoran Dai Zhandong Feng Wenbin Liu Yu Gao Fei Liu Zihan Zhang Na Zhang Xuan Dong Qihan Zhao Xiaoshan Zhou Jieli Du Baoli Liu Source Type: research

Yiqi Huaju formula, a Chinese herbal medicine, reduces arterial pressure in salt‑sensitive hypertension by inhibiting renin‑angiotensin system activation.
Authors: He YM, Yang HJ, Yang Q, Cui JG, Wang TZ, Chen Y, Wang PW, Zhang T, Wang WJ Abstract Hypertension is a chronic disease with a high prevalence, and is associated with a high risk of vascular disease and premature death. Traditional Chinese medicine has been administered to treat hypertension for many years. In the present study, the effects of Yiqi Huaju formula (YQ; a compound used in traditional Chinese herbal medicine) were observed in salt‑sensitive hypertension, which was induced by a high‑salt and high‑fat (HSF) diet and the potential mechanism was investigated. YQ was prepared from five plant ex...
Source: Molecular Medicine Reports - August 6, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Traditional Chinese medicine, Fuzheng Kang ‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway.
Traditional Chinese medicine, Fuzheng Kang‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway. Mol Med Rep. 2017 Jun 30;: Authors: Li L, Wang S, Yang X, Long S, Xiao S, Wu W, Hann SS Abstract Lung cancer is a leading cause of cancer‑associated mortality worldwide, including in developing countries such as China. Traditional Chinese medicine may provide a novel insight for the treatment of patients with lung cancer. The present study aimed to uncover the mechanism by which the Chinese herbal medicine, Fuzheng Kang‑Ai (FZKA), functions on lung cancer cell metastas...
Source: Molecular Medicine Reports - July 6, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

EGFR ‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer.
EGFR‑associated pathways involved in traditional Chinese medicine (TCM)‑1‑induced cell growth inhibition, autophagy and apoptosis in prostate cancer. Mol Med Rep. 2018 Mar 28;: Authors: Wu Z, Zhu Q, Zhang Y, Yin Y, Kang D, Cao R, Tian Q, Lu S, Liu P Abstract Traditional Chinese medicine (TCM) has the synergistic effect of the combination of a single ingredient and a monomer, and systemic and local therapeutic effects in cancer treatment, through which TCM is able to enhance the curative effect and reduce the side effects. The present study analyzed the effect of TCM‑1 (an anti‑cancer TCM) on ...
Source: Molecular Medicine Reports - April 6, 2018 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Hochu‑ekki‑to (Bu‑zhong‑yi‑qi‑tang), a herbal medicine, enhances cisplatin‑induced apoptosis in HeLa cells.
In conclusion, the present study indicated that HET enhanced cisplatin‑induced apoptosis of HeLa cells and that the administration of HET may therefore be clinically beneficial alongside apoptosis‑inducing chemotherapy. PMID: 26239548 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - August 6, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Identification of cardioprotective agents from traditional Chinese medicine against oxidative damage.
Authors: Zhou JM, Xu ZL, Li N, Zhao YW, Wang ZZ, Xiao W Abstract Reactive oxygen species are damaging to cardiomyocytes. H9c2 cardiomyocytes are commonly used to study the cellular mechanisms and signal transduction in cardiomyocytes, and to evaluate the cardioprotective effects of drugs following oxidative damage. The present study developed a robust, automated high throughput screening (HTS) assay to identify cardioprotective agents from a traditional Chinese medicine (TCM) library using a H2O2‑induced oxidative damage model in H9c2 cells. Using this HTS format, several hits were identified as cardioprotective ...
Source: Molecular Medicine Reports - May 15, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Emodin ‑8‑O‑glucuronic acid, from the traditional Chinese medicine qinghuobaiduyin, affects the secretion of inflammatory cytokines in LPS‑stimulated raw 264.7 cells via HSP70.
In conclusion, the present study demonstrated that emodin‑8‑O‑glucuronic acid effectively suppressed LPS‑induced inflammatory cytokine secretion, and this effect was attained by the increased expression of HSP70. PMID: 27430303 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - July 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Traditional Chinese medicine: Pivotal role of the spleen in the metabolism of aristolochic acid I in rats is dependent on oatp2a1.
Authors: Xiang T, Yang Z, Sun B, Luo H, Zhang S, Ren B, Chen X, Zhou X, Chen Z Abstract The genotoxicity and cytotoxicity of aristolochic acids is well documented, and the Aristolochiaceae plant family has been widely used in China and India for medical purposes. However, the mechanisms of aristolochic acid I (AAI) in treatment and toxicity remain to be fully elucidated. According to the theory of traditional Chinese medicine (TCM), the spleen is responsible for transportation and transformation, in which a substance is transformed, absorbed and distributed in the body. In the present study, rats were randomized i...
Source: Molecular Medicine Reports - August 13, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Chinese herbal medicine Xinji pill protects the heart from ischemia/reperfusion injury through the Akt/Nrf2 pathway.
In conclusion, these results demonstrated that XJP exhibited notable cardioprotective properties, in which the Akt/Nrf2 signaling pathway may be involved. PMID: 28627591 [PubMed - as supplied by publisher]
Source: Molecular Medicine Reports - June 21, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Novel herbal medicine LA16001 ameliorates cisplatin-induced anorexia.
Authors: Woo SM, Lee KM, Lee GR, Park JY, Lee HJ, Bahn HJ, Yoon HS, Kim JY, Shin YC, Cho SG, Ko SG Abstract Chemotherapy frequently causes anorexia in cancer patients, which has been associated with poor disease prognosis. Several therapeutic strategies for the treatment of chemotherapy‑induced anorexia are available; however, their adverse effects limit their clinical use. Herbal medicines have a long history of use for the treatment of various diseases, including cancer, and recent research has demonstrated their safety and efficacy. In the present study, combinations of herbal medicines were designed based on ...
Source: Molecular Medicine Reports - December 6, 2017 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Corrigendum Traditional Chinese medicine, Fuzheng Kang ‑Ai decoction, inhibits metastasis of lung cancer cells through the STAT3/MMP9 pathway
Mol Med Rep. 2021 Aug;24(2):600. doi: 10.3892/mmr.2021.12244. Epub 2021 Jun 29.ABSTRACTFollowing the publication of the above article, an interested reader drew to the authors' attention that various of the data panels shown for the cell migration assay experiments in Figs. 2B and 3 appeared to show overlapping regions, such that they were not generated from discretely performed experiments.The authors have re-examined their original data, and realize that the figures in question were assembled incorrectly. In addition, the authors have also realized that certain of the western blotting data panels in Figs. 5 and 6 had lik...
Source: Molecular Medicine Reports - June 29, 2021 Category: Molecular Biology Authors: Longmei Li Sumei Wang Xiaobin Yang Shunqin Long Shujing Xiao Wanyin Wu Swei Sunny Hann Source Type: research

Effects of Dangkwisoo‑san, a traditional herbal medicine for treating pain and blood stagnation, on the pacemaker activities of cultured interstitial cells of Cajal.
Authors: Sung SK, Kim SJ, Ahn TS, Hong NR, Park HS, Kwon YK, Kim BJ Abstract The interstitial cells of Cajal (ICCs) are the pacemaker cells in the gastrointestinal (GI) tract. In the present study, the effects of Dangkwisoo‑san (DS) on pacemaker potentials in cultured ICCs from the small intestine of the mouse were investigated. The whole‑cell patch‑clamp configuration was used to record pacemaker potentials from cultured ICCs and the increase in intracellular Ca2+ concentration ([Ca2+i) was analyzed in cultured ICCs using fura‑2‑acetoxymethyl ester. The generation of pacemaker potentials in the ICCs was ...
Source: Molecular Medicine Reports - August 13, 2015 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Treatment with the herbal medicine, naoxintong improves the protective effect of high‑density lipoproteins on endothelial function in patients with type 2 diabetes.
Authors: Lv P, Tong X, Peng Q, Liu Y, Jin H, Liu R, Sun W, Pan B, Zheng L, Huang Y Abstract The protective effect of high‑density lipoprotein (HDL) on endothelial function is impaired in patients with type 2 diabetes mellitus (T2DM), which may result in atherosclerotic complications. Naoxintong (NXT) is a compound preparation that includes Radix Astragali, Angelicae sinensis, Radix Paeoniae Rubra and Ligusticum wallichii. It is widely administered in China to prevent atherosclerotic complications. In the present study, NXT was administered to 69 patients with T2DM. HDLs were isolated from patient blood sample...
Source: Molecular Medicine Reports - January 21, 2016 Category: Molecular Biology Tags: Mol Med Rep Source Type: research