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Total 47151 results found since Jan 2013.

Evidence-based guideline of the European Association of Nuclear Medicine (EANM) on imaging infection in vascular grafts
CONCLUSION: Computed tomography angiography (CTA) is the first-line imaging modality in suspected VGEI but nuclear medicine modalities are often needed to confirm or exclude the infection. Positron emission tomography/computed tomography (PET/CT) with 2-deoxy-2-[18F]fluoro-D-glucose ([18F]FDG) has very high negative predictive value but it should be performed preferably at least 4 months after surgery to avoid false positive results. Radiolabelled white blood cell (WBC) scintigraphy, given its high diagnostic accuracy, can be performed at any time after surgery.PREAMBLE: The European Association of Nuclear Medicine (EANM) ...
Source: Molecular Medicine - April 4, 2022 Category: Molecular Biology Authors: Chiara Lauri Alberto Signore Andor W J M Glaudemans Giorgio Treglia Olivier Gheysens Riemer H J A Slart Roberto Iezzi Niek H J Prakken Eike Sebastian Debus Susanne Honig Anne Lejay Nabil Chakf é Source Type: research

Gene mutation‐based and specific therapies in precision medicine
Abstract Precision medicine has been initiated and gains more and more attention from preclinical and clinical scientists. A number of key elements or critical parts in precision medicine have been described and emphasized to establish a systems understanding of precision medicine. The principle of precision medicine is to treat patients on the basis of genetic alterations after gene mutations are identified, although questions and challenges still remain before clinical application. Therapeutic strategies of precision medicine should be considered according to gene mutation, after biological and functional mechanisms of m...
Source: Journal of Cellular and Molecular Medicine - March 15, 2016 Category: Molecular Biology Authors: Xiangdong Wang Tags: Editorial Source Type: research

Mechanism of herbal medicine on hypertensive nephropathy (Review).
Abstract Hypertensive nephropathy is the most common complication of hypertension, and is one of the main causes of end‑stage renal disease (ESRD) in numerous countries. The basic pathological feature of hypertensive nephropathy is arteriolosclerosis followed by renal parenchymal damage. The etiology of this disease is complex, and its pathogenesis is mainly associated with renal hemodynamic changes and vascular remodeling. Despite the increased knowledge on the pathogenesis of hypertensive nephropathy, the current clinical treatment methods are still not effective in preventing the development of the disease to...
Source: Molecular Medicine - February 6, 2021 Category: Molecular Biology Authors: Dong Z, Dai H, Feng Z, Liu W, Gao Y, Liu F, Zhang Z, Zhang N, Dong X, Zhao Q, Zhou X, Du J, Liu B Tags: Mol Med Rep Source Type: research

Starring role of Biomarkers and Anticancer Agents as a Major Driver in Precision Medicine of Cancer Therapy
Curr Mol Med. 2021 Dec 21. doi: 10.2174/1566524022666211221152947. Online ahead of print.ABSTRACTPrecision medicine represents the most modern contemporary medicine trend, based on enormous amounts of data relating to people's health, individual characteristics, and life context using the most appropriate strategies to prevent and cure them. Precision medicine in cancer coordinates most precisely and viable treatment to every individual cancer patient based on the disease's genetic profile. Precision medicine changes the standard one size fits all medication model, which has focused on average responses to care. Significan...
Source: Current Molecular Medicine - December 23, 2021 Category: Molecular Biology Authors: Suman Kumar Ray Sukhes Mukherjee Source Type: research

The integrated nuclear medicine and radiology residency program in the Netherlands: strengths and potential areas for improvement according to nuclear medicine physicians and radiologists
CONCLUSION: This study provided insights into the experiences of nuclear medicine physicians and radiologists with the Dutch integrated nuclear medicine and radiology residency program, which may be helpful to improve the program and similar residency programs in other countries.PMID:35194672 | DOI:10.1007/s00259-022-05699-8
Source: Molecular Medicine - February 23, 2022 Category: Molecular Biology Authors: Ton Velleman Thomas C Kwee Rudi A J O Dierckx Yfke P Ongena Walter Noordzij Source Type: research

Diabetes remission after a lifestyle-medicine intervention on type 2 diabetes in lean and obese Chinese subjects: a prospective study
CONCLUSIONS: Lifestyle-medicine interventions may have increased effectiveness in controlling mild T2DM as compared with the oral antidiabetic-based treatment; unexpectedly, there seems no further improvement in lean relative to obese patients. Three in five subjects could achieve diabetes remission though the lifestyle-medicine intervention regardless of whether their BMI was below or above 25 kg/m2.PMID:35523754 | DOI:10.21037/apm-22-369
Source: Molecular Medicine - May 6, 2022 Category: Molecular Biology Authors: Wenying Zou Kunyuan Luo Zhiyong Hu Xiongchou Zhang Cuiping Feng Dingkang Ye Shenghao Liu Qiwei Zhang Rongshao Tan Chengbin Fu Source Type: research

Mechanism of herbal medicine on hypertensive nephropathy (Review)
Mol Med Rep. 2021 Apr;23(4):1. doi: 10.3892/mmr.2021.11873. Epub 2021 Feb 4.ABSTRACTHypertensive nephropathy is the most common complication of hypertension, and is one of the main causes of end‑stage renal disease (ESRD) in numerous countries. The basic pathological feature of hypertensive nephropathy is arteriolosclerosis followed by renal parenchymal damage. The etiology of this disease is complex, and its pathogenesis is mainly associated with renal hemodynamic changes and vascular remodeling. Despite the increased knowledge on the pathogenesis of hypertensive nephropathy, the current clinical treatment methods are s...
Source: Molecular Medicine Reports - February 4, 2021 Category: Molecular Biology Authors: Zhaocheng Dong Haoran Dai Zhandong Feng Wenbin Liu Yu Gao Fei Liu Zihan Zhang Na Zhang Xuan Dong Qihan Zhao Xiaoshan Zhou Jieli Du Baoli Liu Source Type: research

Changes in the global impact of COVID-19 on nuclear medicine departments during 2020: an international follow-up survey
CONCLUSION: The year 2020 has a significant decrease in nuclear medicine diagnostic and therapeutic procedures as a result of the pandemic-related challenges. In June, the global decline recorded in the survey was greater than in October when the situation began to show improvement. However, the total number of procedures remained below those recorded in April 2020 and fell to less than half of the volumes normally carried out pre-pandemic.PMID:34148118 | DOI:10.1007/s00259-021-05444-7
Source: Molecular Medicine - June 20, 2021 Category: Molecular Biology Authors: Francesco Giammarile Roberto C Delgado Bolton Noura El-Haj Lutz S Freudenberg Ken Herrmann Miriam Mikhail Olga Morozova Pilar Orellana Olivier Pellet Enrique Estrada L Sobhan Vinjamuri Gopinath Gnanasegaran Yaroslav Pynda Maria C Navarro-Marulanda Partha Source Type: research

KSNM 60 in General Nuclear Medicine: the Old Dream Comes True
Nucl Med Mol Imaging. 2022 Apr;56(2):71-79. doi: 10.1007/s13139-021-00731-5. Epub 2022 Jan 28.ABSTRACTSince the establishment of the Korean Society of Nuclear Medicine (KSNM) in 1961 by Professor Munho Lee, the KSNM has been progressing in various medical fields. Many papers have been published in the Korean Journal of Nuclear Medicine (KJNM), the official journal of KSNM, since 1967 and other domestic/international journals. Here, we tried to highlight the academic activities of KSNM members from the perspective of general nuclear medicine. After the introduction of the 99Mo/99mTc generator, general nuclear medicine has w...
Source: Molecular Medicine - April 25, 2022 Category: Molecular Biology Authors: Won Woo Lee Jin-Sook Ryu Source Type: research

Induced Pluripotent Stem Cells (iPSCs) Derived From Different Cell Sources and Their Potential for Regenerative and Personalized Medicine.
Abstract Human induced pluripotent stem cells (hiPSCs) have great potential as a robust source of progenitors for regenerative medicine. The novel technology also enables the derivation of patient-specific cells for applications to personalized medicine, such as for personal drug screening and toxicology. However, the biological characteristics of iPSCs are not yet fully understood and their similarity to human embryonic stem cells (hESCs) is still unresolved. Variations among iPSCs, resulting from their original tissue or cell source, and from the experimental protocols used for their derivation, significantly af...
Source: Current Molecular Medicine - May 2, 2013 Category: Molecular Biology Authors: Ronit S, Igal G, Itskovitz-Eldor J Tags: Curr Mol Med Source Type: research

Translational Research of Optical Molecular Imaging for Personalized Medicine.
Abstract In the medical imaging field, molecular imaging is a rapidly developing discipline and forms many imaging modalities, providing us effective tools to visualize, characterize, and measure molecular and cellular mechanisms in complex biological processes of living organisms, which can deepen our understanding of biology and accelerate preclinical research including cancer study and medicine discovery. Among many molecular imaging modalities, although the penetration depth of optical imaging and the approved optical probes used for clinics are limited, it has evolved considerably and has seen spectacular adv...
Source: Current Molecular Medicine - November 11, 2013 Category: Molecular Biology Authors: Qin C, Ma X, Tian J Tags: Curr Mol Med Source Type: research