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Impaired sports performance of athletes suffering from pollen-induced allergic rhinitis: a cross-sectional, observational survey in German athletes.
CONCLUSIONS: This study confirmed a high prevalence of pollen allergy among German athletes. The majority of allergic rhinitis athletes were undertreated and the reason could be their reservations about allergy treatments. Pollen allergy tremendously reduced sports performance of athletes during the pollen season. This impact can be lessened with proper treatment such as immunotherapy. Better understanding of available treatment modalities should be provided to patients and physicians to improve sports performance of athletes suffering from pollen allergy. PMID: 30009588 [PubMed - as supplied by publisher]
Source: Journal of Sports Medicine and Physical Fitness - July 18, 2018 Category: Sports Medicine Tags: J Sports Med Phys Fitness Source Type: research

Pharmacotherapy in allergy medicine: from ‘ipse dixit’ to the evidence-based medicine
Purpose of review The aim of the article is to examine the contributions made in recent years by evidence-based medicine to the understanding, positioning, and use of drugs for the treatment of the main allergic conditions. Recent findings Several antiasthmatic drugs have been reappraised for their efficacy characteristics and drug interactions in Cochrane reviews. The Allergic Rhinitis and its Impact on Asthma (ARIA) guidelines have been reformulated in evidence-based medicine (EBM) terms in 2017; over these years, new point of care instruments contributed to the approximation of the guidelines to real life by drawin...
Source: Current Opinion in Allergy and Clinical Immunology - June 25, 2020 Category: Allergy & Immunology Tags: PHARMACOTHERAPY AND EVIDENCE BASED MEDICINE: Edited by Enrico Compalati and Derek Chu Source Type: research

Positive Role of Chinese Herbal Medicine in Cancer Immune Regulation.
Abstract Complementary and alternative medicine (CAM) plays a critical role in treating cancer patients. Traditional Chinese Medicine (TCM) is the main component of CAM. TCM, especially Chinese Herbal Medicine (CHM), has been increasingly used in China, some other Asian countries and European countries. It has been proven to enhance the efficacy of chemotherapy, radiotherapy, targeted-therapy, and immunotherapy. It lessens the damage caused by these therapies. CHM functions on cancer by inhibiting tumor progression and improving an organism's immune system. Increasing evidence has shown that many CHM exert favorab...
Source: The American Journal of Chinese Medicine - November 13, 2020 Category: Complementary Medicine Authors: Wang S, Long S, Deng Z, Wu W Tags: Am J Chin Med Source Type: research

Regenerative Medicine looking backward 10 years further on.
Abstract The last decade has seen considerable changes in the Regenerative Medicine industry, but unfortunately the hope for numerous treatments that 'replace or regenerate human cells, tissues or organs to restore or establish normal function' has not yet emerged. In contrast to this, there have been major advances in the field of cellular immunotherapy though some do not consider these to be Regenerative Medicines. Regulatory changes have in some cases improved the route to a marketing license but they have not been matched by clarification of the complex, national reimbursement processes for cell-based treatmen...
Source: Regenerative Medicine - November 24, 2016 Category: Genetics & Stem Cells Authors: Kemp P Tags: Regen Med Source Type: research

Perspectives in Radiomics for Personalized Medicine and Theranostics
AbstractRadiomics handles imaging biomarker from high-throughput feature extraction through complex pattern recognition that is difficult for human to process. Recent medical paradigms are rapidly changing to personalized medicine, including molecular targeted therapy, immunotherapy, and theranostics, and the importance of biomarkers for these is growing day by day. Even though biopsy continues to gold standard for tumor assessment in personalized medicine, imaging is expected to complement biopsy because it allows whole tumor evaluation, whole body evaluation, and non-invasive and repetitive evaluation. Radiomics is known...
Source: Nuclear Medicine and Molecular Imaging - January 23, 2019 Category: Nuclear Medicine Source Type: research

Roles of Kampo medicine in chemotherapy ‐related adverse events
ConclusionsThe application of Kampo therapy in cancer supportive care is considered to be indispensable not only for improving treatment outcomes, but also for improving the quality of cancer treatments and the QOL of cancer patients in the latest treatment of cancer.
Source: Traditional and Kampo Medicine - March 22, 2023 Category: Complementary Medicine Authors: Takamasa Nishiuchi, Kotone Nomura, Yu Suezawa Tags: REVIEW Source Type: research

Adult Stem Cells and Medicine.
Authors: Bozdağ SC, Yüksel MK, Demirer T Abstract Stem cells can be either totipotent, pluripotent, multipotent or unipotent. Totipotent cells have the capability to produce all cell types of the developing organism, including both embryonic and extraembryonic tissues. The Hematopoietic Stem Cells (HSC) are the first defined adult stem cells (ASC) that give rise to all blood cells and immune system. Use of HSCs for treatment of hematologic malignancies, which is also called bone marrow (BM) transplantation or peripheral blood stem cells (PBSC) transplantation is the pioneer of cellular therapy and translational r...
Source: Advances in Experimental Medicine and Biology - March 22, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Cloning and expansion of antigen-specific T cells using iPS cell technology: Possible use of regenerated T cells in personalized medicine
Publication date: July 2018Source: Personalized Medicine Universe, Volume 7Author(s): Hiroshi Kawamoto, Kyoko Masuda, Seiji NaganoAbstractRecent advances in adoptive immunotherapy using cytotoxic T lymphocytes (CTLs) have demonstrated that CTLs are effective in killing tumor cells in vivo for some tumor types. However, a critical issue that CTLs collected from patients are easily exhausted during expansion culture is yet to be addressed. Therefore, we have been developing a strategy that utilizes induced pluripotent stem cell (iPSC) technology, based on the idea that iPSCs produced from antigen-specific CTLs would regener...
Source: Personalized Medicine Universe - July 6, 2018 Category: Drugs & Pharmacology Source Type: research

New Penn Medicine Center brings immunotherapy research to brain tumor treatment
(University of Pennsylvania School of Medicine) Penn Medicine is announcing a new Translational Center of Excellence focused on glioblastoma. The team will investigate new immune therapies for glioblastoma and design and test new CAR T cell therapies.
Source: EurekAlert! - Medicine and Health - October 30, 2018 Category: International Medicine & Public Health Source Type: news

Hope and challenge: Precision medicine in bladder cancer
On the basis of the discussion of the benefits of precision medicine in BC, we will also discuss the challenges and limitations facing the non ‐invasive methods of diagnosis and precision therapy of BC. AbstractBladder cancer (BC) is a complex disease and could be classified into nonmuscle ‐invasive BC (NMIBC) or muscle‐invasive BC (MIBC) subtypes according to the distinct genetic background and clinical prognosis. Until now, the golden standard and confirmed diagnosis of BC is cystoscopy and the major problems of BC are the high rate of recurrence and high costs in the clinic. Re cent molecular and genetic studies h...
Source: Cancer Medicine - March 23, 2019 Category: Cancer & Oncology Authors: Hongwei Su, Haitao Jiang, Tao Tao, Xing Kang, Xu Zhang, Danyue Kang, Shucheng Li, Chengxi Li, Haifeng Wang, Zhao Yang, Jinku Zhang, Chong Li Tags: REVIEW Source Type: research

Precision medicine in cow's milk allergy
Purpose of review The aim of this review is to describe the role of precision medicine in the diagnosis, treatment, and monitoring of cow's milk allergy. Recent findings The development of ‘omics’ sciences in the field of food allergy has led to a better understanding of the allergenicity of cow's milk proteins and significant advances in the knowledge of the pathogenesis and mechanisms of cow's milk allergy. Omics-based technologies allow the practitioner to better differentiate cow's milk allergy subtypes and to predict cow's milk allergy (CMA) persistence over time. Precision medicine extends the role of the or...
Source: Current Opinion in Allergy and Clinical Immunology - May 1, 2020 Category: Allergy & Immunology Tags: PERSONALIZED MEDICINE: Edited by Henry Milgrom and René Maximiliano Gómez Source Type: research

Using Traditional Chinese Medicine to Treat Hepatocellular Carcinoma by Targeting Tumor Immunity.
Authors: Jia W, Wang L Abstract As the leading cause of cancer-related death, hepatocellular carcinoma (HCC) threatens human health and limited treatments are available to cure the disease efficiently and effectively. The particularly immunotolerant environment of the liver lowers the efficacy of current therapies in patients with advanced HCC. Traditional Chinese medicine (TCM) is gathering increasing interest due to the immunoregulatory properties of certain compounds. In advanced HCC, TCM can restore immunosurveillance to promote antitumor effects in several ways, including the upregulation of immunostimulatory ...
Source: Evidence-based Complementary and Alternative Medicine - July 2, 2020 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research

The Complementary and Alternative Medicine for Polycystic Ovary Syndrome: A Review of Clinical Application and Mechanism
Evid Based Complement Alternat Med. 2021 Feb 26;2021:5555315. doi: 10.1155/2021/5555315. eCollection 2021.ABSTRACTAs a reproductive endocrine disease, polycystic ovary syndrome (PCOS) has influenced billions of women during childbearing age worldwide. Owing to its complex etiology and ambiguous pathogenesis, there is still not a specific method to cure it. Clinical treatments, such as hormone therapy and surgical treatment, have side effects. Therefore, it is essential and urgent to seek alternative treatment to solve these problems. The satisfactory efficacy of complementary and alternative medicine (CAM), such as traditi...
Source: Evidence-based Complementary and Alternative Medicine - March 17, 2021 Category: Complementary Medicine Authors: Li-Yan Jia Jia-Xing Feng Juan-Li Li Fang-Yuan Liu Liang-Zhen Xie Shou-Juan Luo Feng-Juan Han Source Type: research