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Human Amniotic Membrane-Derived Products in Sports Medicine: Basic Science, Early Results, and Potential Clinical Applications
Conclusion: Amniotic membranes have many promising applications in sports medicine. They are a source of pluripotent cells, highly organized collagen, antifibrotic and anti-inflammatory cytokines, immunomodulators, and matrix proteins. These properties may make it beneficial when applied as tissue engineering scaffolds, improving tissue organization in healing, and treatment of the arthritic joint. The current body of evidence in sports medicine is heavily biased toward in vitro and animal studies, with little to no human clinical data. Nonetheless, 14 companies or distributors offer commercial AM products. The preparation...
Source: The American Journal of Sports Medicine - August 31, 2016 Category: Sports Medicine Authors: Riboh, J. C., Saltzman, B. M., Yanke, A. B., Cole, B. J. Tags: Biology of cartilage, Biology of ligament, Cell/Molecular biology, Growth factors/Healing enhancement, Tissue engineering, Stem cell therapy Current Concepts Source Type: research

Platelet-rich Plasma and Bone Marrow–derived Mesenchymal Stem Cells in Sports Medicine
Regenerative medicine is a fast-growing field in orthopedic sports medicine. Platelet-rich plasma contains multiple factors that have been shown to augment healing, thereby stimulating its use in multiple areas of acute and chronic injuries. Mesenchymal stem cells have pluripotent potential to form into tissues pertinent to orthopedics, such as cartilage and bone. As such, there is been a surge in the research directed toward steering those stem cells into a particular lineage as part of treatment for a variety of soft-tissue, cartilage, and bone pathologies. Overall, there are promising reports of their potential success,...
Source: Sports Medicine and Arthroscopy Review - May 4, 2016 Category: Sports Medicine Tags: Review Articles Source Type: research

Stem Cell Injections for Musculoskeletal Pathology: An Overview for the Sports Medicine Professional
Stem cell injections are a promising nonsurgical biological intervention that seek to augment the body's self-healing capacity. Owing to a growing range of clinical indications and excellent safety profile, sports medicine professionals are likely to encounter individuals who received or are considering stem cell injections. This column provides an overview of stem cell injection procedures, biological mechanisms, and evidence underpinning the potential utility of these interventions for musculoskeletal disorders.
Source: Strength and Conditioning Journal - December 1, 2019 Category: Sports Medicine Tags: Columns: Sports Medicine and Rehabilitation Source Type: research

Australasian College of Sports Physicians-position statement: the place of mesenchymal stem/stromal cell therapies in sport and exercise medicine.
Abstract PURPOSE AND SCOPE: This Position Statement has been written expressly for members of the Australasian College of Sports Physicians (ACSP); however, it may also be of interest to the wider medical community, sporting organisations, athletes and the general community. It has been informed by a comprehensive review of the scientific literature and the opinions of kindred organisations. This statement outlines the use of mesenchymal stem cell (MSC) therapies in the broad context of Sport and Exercise Medicine, recognising that every medical practitioner should respect: (1) the evidence for the therapeutic use...
Source: British Journal of Sports Medicine - December 23, 2015 Category: Sports Medicine Authors: Osborne H, Anderson L, Burt P, Young M, Gerrard D Tags: Br J Sports Med Source Type: research

Sports Medicine
The field of sports medicine is living in a tale of two cities: the best of times and the worst of times. It’s an exciting time, where the boundaries of athleticism and technology are being pushed. We have seen the evolution of extreme sports, including the X Games and long distance running races in extreme terrains for hundreds of miles. Athletes are sustaining a level of peak fitness at an older age, challenging our notion of athletic decline. Technological advances have now allowed us to better understand the pathophysiology of injury and recovery. We can now tap into an athlete’s own cells and tissue to optimize g...
Source: Physical Medicine and Rehabilitation Clinics of North America - July 14, 2014 Category: Rehabilitation Authors: Brian J. Krabak Source Type: research

Biological Therapies in Regenerative Sports Medicine
AbstractRegenerative medicine seeks to harness the potential of cell biology for tissue replacement therapies, which will restore lost tissue functionality. Controlling and enhancing tissue healing is not just a matter of cells, but also of molecules and mechanical forces. We first describe the main biological technologies to boost musculoskeletal healing, including bone marrow and subcutaneous fat-derived regenerative products, as well as platelet-rich plasma and conditioned media. We provide some information describing possible mechanisms of action. We performed a literature search up to January 2016 searching for clinic...
Source: Sports Medicine - September 27, 2016 Category: Sports Medicine Source Type: research

Mesenchymal Stem Cell Therapy in Osteoarthritis and Regenerative Medicine.
PMID: 30531461 [PubMed - in process]
Source: Current Sports Medicine Reports - December 1, 2018 Category: Sports Medicine Authors: Freitag J, Kenihan MA Tags: Curr Sports Med Rep Source Type: research

Biologic Treatments for Sports Injuries II Think Tank--Current Concepts, Future Research, and Barriers to Advancement, Part 1: Biologics Overview, Ligament Injury, Tendinopathy
Biologic therapies, including stem cells, platelet-rich plasma, growth factors, and other biologically active adjuncts, have recently received increased attention in the basic science and clinical literature. At the 2015 AOSSM Biologics II Think Tank held in Colorado Springs, Colorado, a group of orthopaedic surgeons, basic scientists, veterinarians, and other investigators gathered to review the state of the science for biologics and barriers to implementation of biologics for the treatment of sports medicine injuries. This series of current concepts reviews reports the summary of the scientific presentations, roundtable ...
Source: The American Journal of Sports Medicine - November 29, 2016 Category: Sports Medicine Authors: LaPrade, R. F., Geeslin, A. G., Murray, I. R., Musahl, V., Zlotnicki, J. P., Petrigliano, F., Mann, B. J. Tags: Shoulder, rotator cuff, Growth factors/Healing enhancement, Stem cell therapy, Knee, articular cartilage, Biologic healing enhancement, Tendinosis Current Concepts Source Type: research

Stem cells, angiogenesis and muscle healing: a potential role in massage therapies?
Skeletal muscle injuries are among the most common and frequently disabling injuries sustained by athletes. Repair of injured skeletal muscle is an area that continues to present a challenge for sports medicine clinicians and researchers due, in part, to complete muscle recovery being compromised by development of fibrosis leading to loss of function and susceptibility to re-injury. Injured skeletal muscle goes through a series of coordinated and interrelated phases of healing including degeneration, inflammation, regeneration and fibrosis. Muscle regeneration initiated shortly after injury can be limited by fibrosis which...
Source: British Journal of Sports Medicine - May 10, 2013 Category: Sports Medicine Authors: Best, T. M., Gharaibeh, B., Huard, J. Tags: Complementary medicine, Physiotherapy Review Source Type: research

Mesenchymal Stem Cell Therapy in Osteoarthritis and Regenerative Medicine
No abstract available
Source: Current Sports Medicine Reports - December 1, 2018 Category: Sports Medicine Tags: International Federation of Sports Medicine: FIMS International Perspectives Source Type: research

Sports Injuries: Diagnosis, Prevention, Stem Cell Therapy, and Medical Sport Strategy.
Authors: Rahim S, Rahim F, Shirbandi K, Haghighi BB, Arjmand B Abstract Sports injuries diagnosis, prevention, and treatment are the most important issues of sports medicine. Fortunately, sports injuries are often treated effectively, and people with damage recover and return to the sport in a satisfactory condition. Meanwhile, many sports injuries and complications can be prevented. In general, sports injuries include acute or chronic injuries. Given increasing in popularity, sports medicine doctors use stem cells to treat a wide variety of sports injuries, including damage to tendons, ligaments, muscles, and cart...
Source: Advances in Experimental Medicine and Biology - December 13, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

Current Insights into the Potential Misuse of Platelet-based Applications for Doping in Sports
Int J Sports Med DOI: 10.1055/a-0884-0734Platelet-based applications are currently used for the delivery of growth factors and other biomolecules as autologous biomaterials in regenerative medicine and cosmetic therapies. Many studies have revealed that platelet-based applications such as platelet-rich plasma and platelet releasate exhibit beneficial biological effects after a sports injury or trauma when administered locally by intramuscular injections. At present, treatment of the public, patients and athletes with platelet-based applications is permitted and regulated by the Food and Drug Administration and the World An...
Source: International Journal of Sports Medicine - April 22, 2019 Category: Sports Medicine Authors: Scully, David Matsakas, Antonios Tags: Review Source Type: research

Orthobiologics in Pediatric Sports Medicine.
This article reviews orthobiologics and their applications in pediatric sports medicine. PMID: 28577782 [PubMed - in process]
Source: The Orthopedic Clinics of North America - June 6, 2017 Category: Orthopaedics Authors: Bray CC, Walker CM, Spence DD Tags: Orthop Clin North Am Source Type: research

FDA Regulation of Adult Stem Cell Therapies as Used in Sports Medicine
This report provides a brief overview of FDA regulation of adult stem cells. Several common clinical case scenarios are then presented that highlight how stem cells are currently being used in sports medicine and how current FDA regulations are likely to affect the physicians who use them. In the process, it explains how a variety of factors in sourcing and handling these cells, particularly the extent of cell manipulation, will affect what a physician can and cannot do without first obtaining the FDA's express approval.[...]Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals:T...
Source: Journal of Knee Surgery - January 20, 2015 Category: Orthopaedics Authors: Chirba, Mary AnnSweetapple, BerkleyHannon, Charles P.Anderson, John A. Tags: Special Focus Section Source Type: research

The Role of Stem Cells and Tissue Engineering in Orthopaedic Sports Medicine: Current Evidence and Future Directions
The use of stem cell therapies for the treatment of orthopaedic injuries continues to advance. The purpose of this review was to provide an update of the current role and future directions of stem cell strategies in sports medicine. The application of cell-based treatments in the sports medicine arena has expanded in recent years. Promising preclinical results have led to translation of these novel therapies into the clinical setting. Early well-designed comparative clinical studies have also shown positive outcomes.
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - February 25, 2015 Category: Surgery Authors: MaCalus V. Hogan, Garth Walker, Liang Richard Cui, Freddie H. Fu, Johnny Huard Tags: Level V Evidence Source Type: research