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Total 25 results found since Jan 2013.

Nasopharyngeal Metastasis from Breast Carcinoma: A Case Report and a Review of the Literature
We report the case of a 50-year-old woman with a history of a confirmed breast carcinoma under chemotherapy who presented to our department with a unilateral hearing loss and tinnitus. Nasal endoscopy revealed a small bulging mass at the posterior wall of the nasopharynx. The biopsy of the lesion showed an infiltration of the nasopharyngeal mucosa by a mammary adenocarcinoma that was positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2. Computed tomography scan revealed a thickening of the nasopharyngeal mucosa, a pleural and pericardial effusion and diffused secondary ...
Source: Ear, Nose and Throat Journal - August 9, 2022 Category: ENT & OMF Authors: Moncef Sellami Souha Kallel Mariam Ben Ayed Manel Mellouli Tahya Sellami Boudawara Malek Mnejja Bouthaina Hammami Imen Achour Ilhem Charfeddine Source Type: research

Epithelial –myoepithelial carcinoma of the nasopharynx: A case report and review of the literature
ConclusionTo the best of our knowledge, this is the third reported case of EMCa in the nasopharynx and the only case of EMCa in the nasopharynx treated with CCRT, and a partial response was achieved. Therefore, to improve the quality of life and prognosis of patients with unresectable tumors, we believe that CCRT is a suitable option. Further clinical observations are required to elucidate the pathophysiology and prognosis of EMCa.
Source: Frontiers in Oncology - August 5, 2022 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 14, Pages 3422: Definition of an Normal Tissue Complication Probability Model for the Inner Ear in Definitive Radiochemotherapy of Nasopharynx Carcinoma
Conclusion: There is a sigmoidal relation between radiation dose and incidence of inner ear toxicities. Dose constraints for the inner ear of <44 Gy (Dmean) or <58 Gy (Dmax) are suggested to limit the probability of inner ear toxicity <25%.
Source: Cancers - July 14, 2022 Category: Cancer & Oncology Authors: Leonie Peuker Daniel Rolf Michael Oertel Alexander Peuker Sergiu Scobioala Dominik Hering Claudia Rudack Uwe Haverkamp Hans Theodor Eich Tags: Article Source Type: research

Cancers, Vol. 14, Pages 1109: Proton Radiation Therapy for Nasopharyngeal Cancer Patients: Dosimetric and NTCP Evaluation Supporting Clinical Decision
Conclusions: The MBS strategy successfully drives the clinical identification of NPC patients, who are most likely to benefit from IMPT. CTS summarizes well the expected global gain.
Source: Cancers - February 22, 2022 Category: Cancer & Oncology Authors: Alessandro Vai Silvia Molinelli Eleonora Rossi Nicola Alessandro Iacovelli Giuseppe Magro Anna Cavallo Emanuele Pignoli Tiziana Rancati Alfredo Mirandola Stefania Russo Rossana Ingargiola Barbara Vischioni Maria Bonora Sara Ronchi Mario Ciocca Ester Orlan Tags: Article Source Type: research

Middle Ear and Temporal Bone Papilloma: A Clinicopathologic Study and Comprehensive Literature Review of 57 Cases
In conclusion, TBSP is frequently identified in the setting of concurrent sinonasal tract disease, showing similar histologic features to sinonasal tract counterparts. There is no sex predilection, with patients most commonly presenting in the sixth decade of life. Recurrences are common, with carcinoma developing much more frequently than in sinonasal tract papilloma (33%), but recognizing that carcinoma may be documented in either or both anatomic sites. Overall outcome is excellent, with long term clinical follow-up warranted to manage recurrence or m alignant transformation.
Source: Head and Neck Pathology - December 1, 2021 Category: Pathology Source Type: research

Reconstruction of the Anterior External Auditory Canal With Mastoid Cortex Autologous Bone Graft
Conclusions: Anterior EAC reconstruction with autologous bone grafting can be an effective definitive treatment in TMJ herniation. To our knowledge, this is the first report of the use of bone grafting to reconstruct the canal defect in TMJ herniation. Level of Evidence: V.
Source: Otology and Neurotology - November 20, 2021 Category: ENT & OMF Tags: MEDICAL NEUROTOLOGY Source Type: research

Clinical Characteristics and Prognosis of Sudden Sensorineural Hearing Loss in Post-irradiated Nasopharyngeal Carcinoma Survivors
This study was conducted to evaluate the clinical characteristics and prognosis of this population. Study Design: Retrospective cohort study. Setting: Tertiary otology referral center. Patients: Five hundred ninety nine SSNHL patients were recruited between January 2010 and January 2019. Patients were divided into two groups: NPC group (n = 24) and non-NPC group (n = 575). Interventions: All SSNHL patients were diagnosed by pure tone audiometry and treated with steroids, blood flow promoting agents, and hyperbaric oxygen therapy. Main Outcome Measures: We evaluated the clinical characteristics and pr...
Source: Otology and Neurotology - July 30, 2020 Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research

1117PDPembrolizumab and radiotherapy for locally advanced head and neck squamous cell carcinoma (LA-HNSCC) with contraindication to cisplatin therapy
ConclusionsThis is the first study to report acute toxicities of combining pembrolizumab with radiation in LA-HNSCC. Pembrolizumab does not potentiate typical XRT associated toxicities and no unexpected immune related adverse events were observed. Further, lower rates of feeding tube placement and grade 3/4 dermatitis, xerostomia, and mucositis were noted when compared to RTOG1016 (concurrent XRT with cisplatin or cetuximab in LA-HNSCC).Clinical trial identificationNCT02609503.Legal entity responsible for the studyThe authors.FundingMerck Sharp& Dohme Corp.DisclosureAll authors have declared no conflicts of interest.
Source: Annals of Oncology - October 1, 2019 Category: Cancer & Oncology Source Type: research

Milk Consumption Across Life Periods in Relation to Lower Risk of Nasopharyngeal Carcinoma: A Multicentre Case-Control Study
Conclusion: Consumption of milk across life periods was associated with lower risks of NPC. If confirmed to be causal, this has important implications for dairy product consumption and prevention of NPC. Background The etiology of nasopharyngeal carcinoma (NPC) is unclear, and its male predominance has been linked to sex hormones (1). Dairy products are a source of steroid hormones (2) and contain numerous potential antitumor substances. Using an ecological study design, we found that increasing consumption of dairy products might explain the declining NPC incidence in 48 countries/regions (3, 4). Six case-control s...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

Auditory function and quality of life in patients receiving cisplatin chemotherapy in head and neck cancer: A case series follow-up study
Conclusion: The studies have shown hearing loss in higher frequencies, but in our study, we have observed hearing loss at speech frequency in 22.2% of patients receiving cisplatin, who also had low serum albumin levels. Periodic audiometric monitoring and serum albumin level may be helpful to provide timely intervention to prevent further hearing loss and deterioration in the quality of life.
Source: Journal of Cancer Research and Therapeutics - September 7, 2018 Category: Cancer & Oncology Authors: Balamurali Kalyanam N Sarala SM Azeem Mohiyuddin Ravi Diwakar Source Type: research

Clear Cell Variant Squamous Cell Carcinoma of Temporal Bone: Case Report and Literature Review
ConclusionThis case showed a very destructive and bizarre clinical presentation but more report of cases is needed to have a better characterization of the clinical presentation and prognosis of this variant of SCC of temporal bone.
Source: International Journal of Surgery Case Reports - September 2, 2018 Category: Surgery Source Type: research

Long-Term Progression of Sensorineural Hearing Loss and Tinnitus after Combined Intensity-Modulated Radiation Therapy and Cisplatin-Based Chemotherapy for Nasopharyngeal Carcinoma: A Case Report
We report a case of 12-year follow-up from a patient with stage IIB NPC, treated in 2004 with intensity-modulated radiotherapy and cisplatin-based chemotherapy. Pure-tone audiograms were conducted before treatment and at two other points in the 12-year period after treatment. Analysis of the patient ’s audiograms reveals that the development of high-frequency SNHL started after treatment and reached a plateau accompanied by tinnitus approximately 32 months after treatment conclusion. After the plateau, high-frequency SNHL continued to develop slowly in the next 10 years, possibly a long-term effect from radiation-induced...
Source: Case Reports in Oncology - August 9, 2017 Category: Cancer & Oncology Source Type: research

Eagle Syndrome Secondary to Osteoradionecrosis of the Styloid Process.
CONCLUSION: Radiation is a common component of treatment for head and neck cancers. The diagnosis of Eagle syndrome secondary to osteoradionecrosis of the styloid process is an elusive, but important, diagnosis to consider because the condition can be treated successfully. PMID: 28638295 [PubMed - in process]
Source: Ochsner Journal - June 24, 2017 Category: General Medicine Tags: Ochsner J Source Type: research

Benefits, pitfalls and risks of phytotherapy in clinical practice in otorhinolaryngology
Conclusion Scientific proof of the benefit of phytotherapy in otorhinolaryngology remains to be established but, given its widespread use and the reported data, knowledge of this form of treatment needs to be developed.
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases - November 30, 2016 Category: ENT & OMF Source Type: research