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Nasopharyngeal Metastasis from Breast Carcinoma: A Case Report and a Review of the Literature
We report the case of a 50-year-old woman with a history of a confirmed breast carcinoma under chemotherapy who presented to our department with a unilateral hearing loss and tinnitus. Nasal endoscopy revealed a small bulging mass at the posterior wall of the nasopharynx. The biopsy of the lesion showed an infiltration of the nasopharyngeal mucosa by a mammary adenocarcinoma that was positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2. Computed tomography scan revealed a thickening of the nasopharyngeal mucosa, a pleural and pericardial effusion and diffused secondary ...
Source: Ear, Nose and Throat Journal - August 9, 2022 Category: ENT & OMF Authors: Moncef Sellami Souha Kallel Mariam Ben Ayed Manel Mellouli Tahya Sellami Boudawara Malek Mnejja Bouthaina Hammami Imen Achour Ilhem Charfeddine Source Type: research

Epithelial –myoepithelial carcinoma of the nasopharynx: A case report and review of the literature
ConclusionTo the best of our knowledge, this is the third reported case of EMCa in the nasopharynx and the only case of EMCa in the nasopharynx treated with CCRT, and a partial response was achieved. Therefore, to improve the quality of life and prognosis of patients with unresectable tumors, we believe that CCRT is a suitable option. Further clinical observations are required to elucidate the pathophysiology and prognosis of EMCa.
Source: Frontiers in Oncology - August 5, 2022 Category: Cancer & Oncology Source Type: research

Cancers, Vol. 14, Pages 3422: Definition of an Normal Tissue Complication Probability Model for the Inner Ear in Definitive Radiochemotherapy of Nasopharynx Carcinoma
Conclusion: There is a sigmoidal relation between radiation dose and incidence of inner ear toxicities. Dose constraints for the inner ear of <44 Gy (Dmean) or <58 Gy (Dmax) are suggested to limit the probability of inner ear toxicity <25%.
Source: Cancers - July 14, 2022 Category: Cancer & Oncology Authors: Leonie Peuker Daniel Rolf Michael Oertel Alexander Peuker Sergiu Scobioala Dominik Hering Claudia Rudack Uwe Haverkamp Hans Theodor Eich Tags: Article Source Type: research

Cancers, Vol. 14, Pages 1109: Proton Radiation Therapy for Nasopharyngeal Cancer Patients: Dosimetric and NTCP Evaluation Supporting Clinical Decision
Conclusions: The MBS strategy successfully drives the clinical identification of NPC patients, who are most likely to benefit from IMPT. CTS summarizes well the expected global gain.
Source: Cancers - February 22, 2022 Category: Cancer & Oncology Authors: Alessandro Vai Silvia Molinelli Eleonora Rossi Nicola Alessandro Iacovelli Giuseppe Magro Anna Cavallo Emanuele Pignoli Tiziana Rancati Alfredo Mirandola Stefania Russo Rossana Ingargiola Barbara Vischioni Maria Bonora Sara Ronchi Mario Ciocca Ester Orlan Tags: Article Source Type: research

Middle Ear and Temporal Bone Papilloma: A Clinicopathologic Study and Comprehensive Literature Review of 57 Cases
In conclusion, TBSP is frequently identified in the setting of concurrent sinonasal tract disease, showing similar histologic features to sinonasal tract counterparts. There is no sex predilection, with patients most commonly presenting in the sixth decade of life. Recurrences are common, with carcinoma developing much more frequently than in sinonasal tract papilloma (33%), but recognizing that carcinoma may be documented in either or both anatomic sites. Overall outcome is excellent, with long term clinical follow-up warranted to manage recurrence or m alignant transformation.
Source: Head and Neck Pathology - December 1, 2021 Category: Pathology Source Type: research

Clinical Characteristics and Prognosis of Sudden Sensorineural Hearing Loss in Post-irradiated Nasopharyngeal Carcinoma Survivors
This study was conducted to evaluate the clinical characteristics and prognosis of this population. Study Design: Retrospective cohort study. Setting: Tertiary otology referral center. Patients: Five hundred ninety nine SSNHL patients were recruited between January 2010 and January 2019. Patients were divided into two groups: NPC group (n = 24) and non-NPC group (n = 575). Interventions: All SSNHL patients were diagnosed by pure tone audiometry and treated with steroids, blood flow promoting agents, and hyperbaric oxygen therapy. Main Outcome Measures: We evaluated the clinical characteristics and pr...
Source: Otology and Neurotology - July 30, 2020 Category: ENT & OMF Tags: SENSORINEURAL HEARING LOSS AND TINNITUS Source Type: research

Milk Consumption Across Life Periods in Relation to Lower Risk of Nasopharyngeal Carcinoma: A Multicentre Case-Control Study
Conclusion: Consumption of milk across life periods was associated with lower risks of NPC. If confirmed to be causal, this has important implications for dairy product consumption and prevention of NPC. Background The etiology of nasopharyngeal carcinoma (NPC) is unclear, and its male predominance has been linked to sex hormones (1). Dairy products are a source of steroid hormones (2) and contain numerous potential antitumor substances. Using an ecological study design, we found that increasing consumption of dairy products might explain the declining NPC incidence in 48 countries/regions (3, 4). Six case-control s...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

Long-Term Progression of Sensorineural Hearing Loss and Tinnitus after Combined Intensity-Modulated Radiation Therapy and Cisplatin-Based Chemotherapy for Nasopharyngeal Carcinoma: A Case Report
We report a case of 12-year follow-up from a patient with stage IIB NPC, treated in 2004 with intensity-modulated radiotherapy and cisplatin-based chemotherapy. Pure-tone audiograms were conducted before treatment and at two other points in the 12-year period after treatment. Analysis of the patient ’s audiograms reveals that the development of high-frequency SNHL started after treatment and reached a plateau accompanied by tinnitus approximately 32 months after treatment conclusion. After the plateau, high-frequency SNHL continued to develop slowly in the next 10 years, possibly a long-term effect from radiation-induced...
Source: Case Reports in Oncology - August 9, 2017 Category: Cancer & Oncology Source Type: research

Inner ear deficits in irradiated nasopharyngeal carcinoma survivors
ConclusionsA significant sequential decline in inner ear function of irradiated NPC survivors was observed from the saccule to the utricle, cochlea, and semicircular canals. Most of them were due to sequela of otitis media, followed by central vestibular disorder. Level of Evidence4. Laryngoscope, 2015
Source: The Laryngoscope - May 6, 2015 Category: ENT & OMF Authors: Fan‐Hsiang Chi, Yi‐Ho Young Tags: Head and Neck Source Type: research

Nasopharyngeal carcinoma with metastases to colon
Publication date: Available online 21 February 2015 Source:Egyptian Journal of Ear, Nose, Throat and Allied Sciences Author(s): Yatiee Swany Lahuri , Irfan Mohamad , Hasmah Hashim Squamous cell carcinoma (SCC) of the nasopharynx is amongst the most common head and neck cancers. The most common distant metastases are to the bone, liver and lung. Herein, we are reporting a rare case of a 61-year-old man with nasopharyngeal carcinoma (NPC) who presented with 3weeks history of blood streaked sputum, post nasal drip and blocked nose with no history of epistaxis, tinnitus and unilateral hearing loss. Almost 2years upon complet...
Source: Egyptian Journal of Ear, Nose, Throat and Allied Sciences - March 1, 2015 Category: ENT & OMF Source Type: research

Large cell neuroendocrine carcinoma of the nasopharynx: A case report.
We report a 35-year-old patient who consulted for tinnitus and nasal obstruction. The assessment found a nasopharyngeal tumour T4N0M0. The patient underwent 6 cycles of chemotherapy based on VP16 and cisplatin, followed by radiotherapy at a dose of 70Gy to the nasopharynx and 50Gy to the neck. The evolution was marked by clinical improvement and radiological stability. Six months after the end of treatment, the patient had a local and meningeal relapse. He received palliative care. He died 19 months after the end of treatment. PMID: 24837649 [PubMed - as supplied by publisher]
Source: Cancer Radiotherapie - May 13, 2014 Category: Cancer & Oncology Authors: Elloumi F, Fourati N, Siala W, Ghorbell L, Jlidi R, Ghorbel A, Frikha M, Daoud J Tags: Cancer Radiother Source Type: research

Nasopharyngeal carcinoma in children and adolescents in an endemic area: A report of 185 cases
Conclusions: In spite of the majority of patients diagnosed at the advanced stage, children and adolescents with NPC had excellent survival except metastatic disease. The TNM stage was the most relevant prognostic factor. A higher radiation dose (>68Gy) could not improve survival but could increase long-term morbidities.
Source: International Journal of Pediatric Otorhinolaryngology - September 1, 2013 Category: ENT & OMF Authors: Zheng Yan, Liangping Xia, Yuanyuan Huang, Ping Chen, Li Jiang, Bei Zhang Tags: Research papers Source Type: research