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Acori Tatarinowii Rhizoma: A comprehensive review of its chemical composition, pharmacology, pharmacokinetics and toxicity
Acori Tatarinowii Rhizoma (ATR, Shi Chang Pu in Chinese), a natural product with multiple targets in various diseases. This review provides the comprehensive summary of the chemical composition, pharmacological effects, pharmacokinetics parameters and toxicity of ATR. The results indicated that ATR possesses a wide spectrum of chemical composition, including volatile oil, terpenoids, organic acids, flavonoids, amino acids, lignin, carbohydrates and so on. Accumulating evidence from various studies has shown that ATR exerts a wide range of pharmacological properties, including protecting nerve cells, alleviating learning an...
Source: Frontiers in Pharmacology - March 16, 2023 Category: Drugs & Pharmacology Source Type: research

Effects of Apatinib Mesylate Monotherapy on the Incidence of Adverse Reactions and Immune Function in Patients with Breast Cancer after Radical Mastectomy
CONCLUSION: Apatinib mesylate monotherapy after radical mastectomy yields a high DCR, a lower incidence of adverse events, and improved immune recovery. Clinical trials are, however, required prior to clinical promotion.PMID:35990841 | PMC:PMC9385297 | DOI:10.1155/2022/4022282
Source: Evidence-based Complementary and Alternative Medicine - August 22, 2022 Category: Complementary Medicine Authors: Sen Lin Meichun Zang Source Type: research

Why Do We Dream? A New Theory on How It Protects Our Brains
When he was two years old, Ben stopped seeing out of his left eye. His mother took him to the doctor and soon discovered he had retinal cancer in both eyes. After chemotherapy and radiation failed, surgeons removed both his eyes. For Ben, vision was gone forever. But by the time he was seven years old, he had devised a technique for decoding the world around him: he clicked with his mouth and listened for the returning echoes. This method enabled Ben to determine the locations of open doorways, people, parked cars, garbage cans, and so on. He was echolocating: bouncing his sound waves off objects in the environment and cat...
Source: TIME: Science - December 29, 2020 Category: Science Authors: David Eagleman and Don Vaughn Tags: Uncategorized Source Type: news

Generalizability assessment of head and neck cancer NTCP models based on the TRIPOD criteria.
Abstract This review aimed to provide an overview of the level of maturity of normal tissue complication probability (NTCP) models for head and neck cancer (HNC) patients. A systematic literature review was performed to retrieve NTCP models for HNC toxicities. Patient population characteristics, NTCP model and the predictors, treatment technique and endpoint definition were extracted per article. Models were then scored based on the TRIPOD (transparent reporting of a multivariable prediction model for individual prognosis or diagnosis) consensus guidelines to evaluate their generalizability. 335 articles on photon...
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - March 6, 2020 Category: Radiology Authors: Sharabiani M, Clementel E, Andratschke N, Hurkmans C Tags: Radiother Oncol Source Type: research

Symptom distress and interference among cancer patients with osteoradionecrosis of jaw: A cross-sectional study
ConclusionsORNJ patients suffered mainly from limited mouth opening and other maxillofacial symptoms. The problem of limited mouth opening was more severe in patients with longer time to onset of ORNJ after radiotherapy. ORNJ patients commonly had symptom distress, which influenced their quality of life.
Source: International Journal of Nursing Sciences - June 4, 2019 Category: Nursing Source Type: research

Could the biological robustness of low level laser therapy (Photobiomodulation) impact its use in the management of mucositis in head and neck cancer patients
Low level laser therapy (LLLT) was first introduced for potential clinical applications by Mester in the late 1960s. This form of laser treatment, currently referred to as photobiomodulation (PBM), limits radiation intensity by transferring low energy to tissues and thereby does not generate heat. Among the clinical indications for which LLLT has been reported to be efficacious are pain relief (back and neck, orthodontic, shoulder), wound healing, carpal tunnel syndrome, colorectal cancer, elbow disorders, fibromyalgia, lymphedema, musculoskeletal dysfunction, myofascial pain syndrome, neurological dysfunctions, patella-fe...
Source: Oral Oncology - February 3, 2016 Category: Cancer & Oncology Authors: Stephen T. Sonis, Sepehr Hashemi, Joel B. Epstein, Raj G. Nair, Judith E. Raber-Durlacher Tags: Review Source Type: research

Phase 1 trial of the oral AKT inhibitor MK-2206 plus carboplatin/paclitaxel, docetaxel, or erlotinib in patients with advanced solid tumors
Conclusion: MK-2206 plus carboplatin and paclitaxel, docetaxel, or erlotinib was well-tolerated, with early evidence of antitumor activity.Trial registrationClinicalTrials.gov: NCT00848718.
Source: Journal of Hematology and Oncology - January 3, 2014 Category: Hematology Authors: L MolifeLi YanJoanna Vitfell-RasmussenAdriane ZernheltDaniel SullivanPhilippe CassierEric ChenAndrea BiondoErnestina TettehLillian SiuAmita PatnaikKyriakos PapadopoulosJohann de BonoAnthony TolcherSusan Minton Source Type: research