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Ototoxicity After Cisplatin-Based Chemotherapy: Factors Associated With Discrepancies Between Patient-Reported Outcomes and Audiometric Assessments
Objectives: To provide new information on factors associated with discrepancies between patient-reported and audiometrically defined hearing loss (HL) in adult-onset cancer survivors after cisplatin-based chemotherapy (CBCT) and to comprehensively investigate risk factors associated with audiometrically defined HL. Design: A total of 1410 testicular cancer survivors (TCS) ≥6 months post-CBCT underwent comprehensive audiometric assessments (0.25 to 12 kHz) and completed questionnaires. HL severity was defined using American Speech-Language-Hearing Association criteria. Multivariable multinomial regression ide...
Source: Ear and Hearing - April 17, 2022 Category: Audiology Tags: Research Articles Source Type: research

Pharmacogenomics of cisplatin ‐induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy
ConclusionsGenetics variants inTXNRD1 and WNT8A are notable risk factors for hearing loss and tinnitus, respectively. Future studies should investigate these genes and if replicated, identify their potential impact on preventive strategies.
Source: Cancer Medicine - March 24, 2022 Category: Cancer & Oncology Authors: Xindi Zhang, Matthew R. Trendowski, Emma Wilkinson, Mohammad Shahbazi, Paul C. Dinh, Megan M. Shuey, Regeneron Genetics Center, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Robert Huddart, N Tags: RESEARCH ARTICLE Source Type: research

Speech perception 30 years after cisplatin-based chemotherapy in adults: limited clinical relevance of long-term ototoxicity?
CONCLUSIONS: Cisplatin causes high-frequency hearing loss, but speech perception tests performed both in quiet and in background noise 30 years post-treatment indicate that the clinical relevance is limited for most patients. Few patients develop severe hearing loss that requires rehabilitation but it is important to identify these patients. Self-reported hearing loss and tinnitus were more common among Cases compared with Controls.PMID:33617403 | DOI:10.1080/0284186X.2021.1887514
Source: Acta Oncologica - February 22, 2021 Category: Cancer & Oncology Authors: J Skalleberg M Myhrum M C Sm åstuen T A Osnes S D Foss å M Bunne Source Type: research

Clinical and Genome-Wide Analysis of Multiple Severe Cisplatin-Induced Neurotoxicities in Adult-Onset Cancer Survivors.
CONCLUSIONS: Certain survivors are more susceptible to cisplatin-induced neurotoxicity, markedly increasing likelihood of developing numerous neuro-otological symptoms that affect quality of life. Genome-wide analysis identified genetic variation in FAM20C as a potentially important risk factor. PMID: 32998964 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - September 29, 2020 Category: Cancer & Oncology Authors: Trendowski MR, Wheeler HE, El Charif O, Feldman DR, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Einhorn LH, Travis LB, Dolan ME Tags: Clin Cancer Res Source Type: research

Testicular Cancer Survivorship.
Authors: Fung C, Dinh PC, Fossa SD, Travis LB Abstract Testicular cancer (TC) is the most common cancer among men aged 18 to 39 years. It is highly curable, with a 10-year relative survival approaching 95% due to effective cisplatin-based chemotherapy. Given the increasing incidence of TC and improved survival, TC survivors (TCS) now account for approximately 4% of all US male cancer survivors. They have also become a valuable cohort for adult-onset cancer survivorship research, given their prolonged survival. Commensurately, long-term treatment-related complications have emerged as important survivorship issues. T...
Source: Journal of the National Comprehensive Cancer Network : JNCCN - December 6, 2019 Category: Cancer & Oncology Tags: J Natl Compr Canc Netw Source Type: research

Clinical and Genome-Wide Analysis of Serum Platinum Levels after Cisplatin-Based Chemotherapy.
Conclusions: This study indicates that residual platinum values are correlated with several cisplatin-related toxicities. One genetic variant is associated with these levels. PMID: 31296530 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - July 10, 2019 Category: Cancer & Oncology Authors: Trendowski MR, El Charif O, Ratain MJ, Monahan P, Mu Z, Wheeler HE, Dinh PC, Feldman DR, ArdeshirRouhaniFard S, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Kubo M, Hannigan R, Strathmann FG, Einhorn LH, Fossa SD, Travis LB, Dolan ME Tags: Clin Cancer Res Source Type: research

Adjuvant carboplatin therapy in patients with clinical stage 1 testicular seminoma: is long-term morbidity increased?
ConclusionsThis study found a 2.4-fold higher than expected rate of SMN —and a slightly increased rate of hypogonadism—in the long-term period following carboplatin treatment. Although further studies are needed to confirm these preliminary findings, these results are probably informative for clinicians caring for seminoma patients.
Source: Journal of Cancer Research and Clinical Oncology - July 7, 2019 Category: Cancer & Oncology Source Type: research

Clinical and Genome-Wide Analysis of Cisplatin-Induced Tinnitus Implicates Novel Ototoxic Mechanisms.
CONCLUSIONS: CisIT associated with several neuro-otological symptoms, increased use of psychotropic medication, and poorer health. OTOS, expressed in the cochlear lateral wall, was implicated as protective. Future studies should investigate otoprotective targets in supporting cochlear cells. PMID: 30952644 [PubMed - as supplied by publisher]
Source: Clinical Cancer Research - April 4, 2019 Category: Cancer & Oncology Authors: El Charif O, Mapes B, Trendowski MR, Wheeler HE, Wing C, Dinh PC, Frisina RD, Feldman DR, Hamilton R, Vaughn DJ, Fung C, Kollmannsberger C, Mushiroda T, Kubo M, Gamazon ER, Cox N, Huddart R, ArdeshirRouhaniFard S, Monahan P, Fossa SD, Einhorn LH, Travis L Tags: Clin Cancer Res Source Type: research

A Qualitative Analysis of the Impact of Carboplatin AUC 10 on Physical, Work Functioning and Bone Marrow Toxicity Among Seminoma Patients - A Single-centre Experience
Conclusion: Carboplatin AUC10 is a safe and effective treatment for stage II/III seminoma with better health-related quality of life than experienced with combination cisplatin-based chemotherapy.
Source: In Vivo - December 26, 2018 Category: Research Authors: MILIC, M., HALL, M., HAWKINS, A., GOGBASHIAN, A., RUSTIN, G., SHARMA, A. Tags: Clinical Studies Source Type: research

Long-term serum platinum changes and their association with cisplatin-related late effects in testicular cancer survivors.
CONCLUSION: In summary, we found a significant association between a larger Pt decline and a reduced risk of second cancers and deterioration of paresthesias in hands and tinnitus. PMID: 29775128 [PubMed - as supplied by publisher]
Source: Acta Oncologica - May 18, 2018 Category: Cancer & Oncology Authors: Hjelle LV, Gundersen POM, Hellesnes R, Sprauten M, Brydøy M, Tandstad T, Wilsgaard T, Fosså SD, Oldenburg J, Bremnes RM, Haugnes HS Tags: Acta Oncol Source Type: research

Associations between long-term serum platinum and neurotoxicity and ototoxicity, endocrine gonadal function, and cardiovascular disease in testicular cancer survivors.
CONCLUSION: Median 19 years after treatment, increasing quartiles of se-Pt are associated with increasing SCIN score, tinnitus, hearing impairment, and increasing LH levels. However, these associations remained significant only for tinnitus and LH when adjusting for administered cisplatin dose. PMID: 27523611 [PubMed - as supplied by publisher]
Source: Urologic Oncology - August 10, 2016 Category: Urology & Nephrology Authors: Hjelle LV, Bremnes RM, Gundersen PO, Sprauten M, Brydøy M, Tandstad T, Wilsgaard T, Fosså SD, Oldenburg J, Haugnes HS Tags: Urol Oncol Source Type: research

Ma2 Autoantibody-Negative Multifocal Paraneoplastic Neurological Disorder Associated with Metastatic Testicular Cancer. (P4.049)
CONCLUSIONS: This case illustrates a seminoma-associated multi-focal paraneoplastic neurological disorder. The absence of a definable neural autoantibody does not preclude a paraneoplastic diagnosis. The apparently favorable response to cranial irradiation is of interest. It was performed on the basis of misinterpretation of MRI brain abnormalities as metastases.Disclosure: Dr. Linnoila has nothing to disclose. Dr. Lennon stands to receive royalty payments for commercial assays to detect of Aquaporin 4-specific Autoantibody. Dr. Pittock's institution has received compensation for activities with Alexion Pharmaceuticals, Me...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Linnoila, J., Lennon, V., Pittock, S. Tags: MS and CNS Inflammatory Diseases: CNS Inflammatory Diseases and Differential Diagnosis Source Type: research