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The effect of lidocaine iontophoresis for the treatment of tinnitus: a systematic review
ConclusionsDue to the heterogeneity and the limited quality of the studies found, no clear statement can be made about the efficacy. The number of those who benefited from therapy varied widely. In addition, it cannot be ruled out that the effect was merely due to electrical stimulation of the cochlea.
Source: European Archives of Oto-Rhino-Laryngology - September 14, 2022 Category: ENT & OMF Source Type: research

Lidocaine injections to the otic ganglion for the treatment of tinnitus-A pilot study
Prog Brain Res. 2021;260:355-366. doi: 10.1016/bs.pbr.2020.08.006. Epub 2020 Oct 2.ABSTRACTTinnitus is defined as the perception of noise without an external acoustic stimulus. Due to the heterogeneity of tinnitus, no treatment has proven equally beneficial to every single of these patients. Previous studies have shown that trigeminal input can interfere with the perception of tinnitus. Therefore, we aimed to explore the therapeutic potential of lidocaine injections in trigeminal structures. We conducted a pilot study with 19 participants to explore feasibility and tolerability of this approach. The intervention consisted ...
Source: Brain Research - February 27, 2021 Category: Neurology Authors: Veronika Vielsmeier Winfried Schlee Berthold Langguth Peter M Kreuzer Constantin Hintschich Lea Strohmeyer Jorge Simoes Eberhard Biesinger Source Type: research

HEALTH NOTES: Neck patch silences ear ringing agony of tinnitus  
Experts at the University of West Virginia have been using patches containing lidocaine - a drug normally used in dentistry - to treat tinnitus which affects about five million people in Britain.
Source: the Mail online | Health - March 30, 2019 Category: Consumer Health News Source Type: news

Transdermal lidocaine as treatment for chronic subjective tinnitus: A pilot study
ConclusionsIn this preliminary study, 5% transdermal lidocaine appears to be a potential treatment for chronic subjective tinnitus. The majority of subjects who completed 1 month of treatment had clinically significantly improved tinnitus. These findings are confounded however by the small sample size and significant drop out rate.
Source: American Journal of Otolaryngology - March 18, 2019 Category: Endocrinology Source Type: research

The analgesic efficacy and duration of lidocaine on vascular pain induced by hypertonic saline infusion: a double-blinded, randomized control trial
ConclusionA single bolus of Lidocaine was effective in eliminating the pain induced by hypertonic saline infusion, but just for a short period of time. Lidocaine (without venous occlusion) only provides a short analgesic duration for local vein.
Source: Journal of Anesthesia - March 4, 2019 Category: Anesthesiology Source Type: research

Therapeutic Approaches to the Treatment of Tinnitus.
Abstract Tinnitus is a highly prevalent condition that is associated with hearing loss in most cases. In the absence of external stimuli, phantom perceptions of sounds emerge from alterations in neuronal activity within central auditory and nonauditory structures. Pioneering studies using lidocaine revealed that tinnitus is susceptible to pharmacological interventions. However, lidocaine is not effective in all patients, and no other drug has been identified with clear efficacy for the long-term treatment of tinnitus. In this review, we present recent advances in tinnitus research, including more detailed knowledg...
Source: Pharmacological Reviews - July 25, 2018 Category: Drugs & Pharmacology Authors: Langguth B, Elgoyhen AB, Cederroth CR Tags: Annu Rev Pharmacol Toxicol Source Type: research

Lidocaine Spray Versus Paracervical Block During Loop Electrosurgical Excision Procedure: A Randomized Trial
Conclusions The local 40 mg of 10% LS can be used to substitute for PB for pain control during LEEP of the cervix. It also resulted in fewer adverse effects.
Source: Journal of Lower Genital Tract Disease - January 1, 2018 Category: OBGYN Tags: Original Research Articles: Cervix and HPV Source Type: research

Effects of two different local anaesthetic methods vs no anaesthesia on pain scores for intratympanic injections.
CONCLUSION: Neither of the local anaesthetics was found to be superior to having no anaesthesia. PMID: 27821219 [PubMed - as supplied by publisher]
Source: Journal of Laryngology and Otology - November 10, 2016 Category: ENT & OMF Tags: J Laryngol Otol Source Type: research

Tinnitus: Evaluation of Intratympanic Injection of Combined Lidocaine and Corticosteroids
Conclusion: There were statistically significant differences between both groups. ITLD seems to be effective for idiopathic tinnitus.ORL 2016;78:159-166
Source: ORL - May 31, 2016 Category: ENT & OMF Source Type: research

Pharmacotherapy for tinnitus: much ado about nothing.
CONCLUSIONS. The use of pharmacotherapy in reducing the severity of tinnitus is not well supported by prospective, randomized, placebo-controlled clinical trials. Various drugs have been shown to be effective in some studies, but the clinical evidence is limited. Large randomized clinical trials are needed. PMID: 25059267 [PubMed - in process]
Source: Revista de Neurologia - July 29, 2014 Category: Neurology Authors: Espinosa-Sanchez JM, Heitzmann-Hernandez T, Lopez-Escamez JA Tags: Rev Neurol Source Type: research