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Total 23 results found since Jan 2013.

History of Tinnitus Research at the VA National Center for Rehabilitative Auditory Research (NCRAR), 1997 –2021: Studies and Key Findings
Semin Hear DOI: 10.1055/s-0043-1770140The Veterans Affairs (VA) Rehabilitation Research & Development (RR&D) National Center for Rehabilitative Auditory Research (NCRAR) was first funded by the RR&D Service in 1997 and has been funded continuously since that time. The overall purpose of the NCRAR is to “improve the quality of life of Veterans and others with hearing and balance problems through clinical research, technology development, and education that leads to better patient care” ( www.ncrar.research.va.gov ). An important component of the research conducted at the NCRAR has been a focus on clini...
Source: Seminars in Hearing - June 22, 2023 Category: Audiology Authors: Henry, James A. Folmer, Robert L. Zaugg, Tara L. Theodoroff, Sarah M. Quinn, Candice M. Reavis, Kelly M. Thielman, Emily J. Carlson, Kathleen F. Tags: Review Article Source Type: research

Sensors, Vol. 23, Pages 902: Prediction of Tinnitus Treatment Outcomes Based on EEG Sensors and TFI Score Using Deep Learning
mich Wei Qi Yan Tinnitus is a hearing disorder that is characterized by the perception of sounds in the absence of an external source. Currently, there is no pharmaceutical cure for tinnitus, however, multiple therapies and interventions have been developed that improve or control associated distress and anxiety. We propose a new Artificial Intelligence (AI) algorithm as a digital prognostic health system that models electroencephalographic (EEG) data in order to predict patients&rsquo; responses to tinnitus therapies. The EEG data was collected from patients prior to treatment and 3-months following a sound-...
Source: Sensors - January 12, 2023 Category: Biotechnology Authors: Maryam Doborjeh Xiaoxu Liu Zohreh Doborjeh Yuanyuan Shen Grant Searchfield Philip Sanders Grace Y. Wang Alexander Sumich Wei Qi Yan Tags: Article Source Type: research

Alterations in auditory brain stem response distinguish occasional and constant tinnitus
CONCLUSIONS Our results support the hypothesis that the transition from occasional to constant tinnitus is accompanied by neuronal changes in the midbrain leading to a persisting tinnitus, which is then less likely to remit.FUNDING This study was supported by the GENDER-Net Co-Plus Fund (GNP-182), the European Union’s Horizon 2020 grants no. 848261 (Unification of Treatments and Interventions for Tinnitus [UNITI]) and no. 722046 (European School for Interdisciplinary Tinnitus Research [ESIT]).
Source: Journal of Clinical Investigation - March 1, 2022 Category: Biomedical Science Authors: Niklas K. Edvall, Golbarg Mehraei, Martin Claeson, Andra Lazar, Jan Bulla, Constanze Leineweber, Inger Uhlén, Barbara Canlon, Christopher R. Cederroth Source Type: research

Towards a unification of treatments and interventions for tinnitus patients: The EU research and innovation action UNITI
Prog Brain Res. 2021;260:441-451. doi: 10.1016/bs.pbr.2020.12.005. Epub 2021 Feb 4.ABSTRACTTinnitus is the perception of a phantom sound and the patient's reaction to it. Although much progress has been made, tinnitus remains a scientific and clinical enigma of high prevalence and high economic burden, with an estimated prevalence of 10%-20% among the adult population. The EU is funding a new collaborative project entitled "Unification of Treatments and Interventions for Tinnitus Patients" (UNITI, grant no. 848261) under its Horizon 2020 framework. The main goal of the UNITI project is to set the ground for a predictive co...
Source: Brain Research - February 27, 2021 Category: Neurology Authors: Winfried Schlee Stefan Schoisswohl Susanne Staudinger Axel Schiller Astrid Lehner Berthold Langguth Martin Schecklmann Jorge Simoes Patrick Neff Steven C Marcrum Myra Spiliopoulou Uli Niemann Miro Schleicher Vishnu Unnikrishnan Clara Puga Lena Mulansky Ru Source Type: research

Prediction of tinnitus masking benefit within a case series using a spiking neural network model
We examined individual tinnitus and psychological responses to three masking types, energetic masking (bilateral broadband static or rain noise [BBN]), informational masking (BBN with a notch at tinnitus pitch and 3-dimensional cues) and a masker combining both effects (BBN with spatial cues). Eleven participants with chronic tinnitus were followed for 12 months, each person used each masking approach for 3 months with a 1 month washout-baseline. The Tinnitus Functional Index (TFI), Tinnitus Rating Scales, Positive and Negative Affect Scale and Depression Anxiety Stress Scales, were measured every month of treatment. Elect...
Source: Brain Research - February 27, 2021 Category: Neurology Authors: Mithila Durai Philip Sanders Zohreh Doborjeh Maryam Doborjeh Anne Wendt Nikola Kasabov Grant D Searchfield Source Type: research

FDA Panel Greenlights First Single-Shot COVID-19 Vaccine, from Johnson & Johnson
The U.S. Food and Drug Administration’s (FDA) vaccine advisory committee earlier today (Feb. 26) voted unanimously to recommend Johnson & Johnson’s COVID-19 vaccine for emergency use authorization. While the FDA isn’t obligated to follow the committee’s advice, it generally does. At the end of a full day of review and discussion of the company’s shot, all 22 voting members of the committee agreed that the vaccine was safe and effective enough to be used by the public. It’s the third vaccine that the group of independent experts has recommended, following Pfizer-BioNTech and Moderna. ...
Source: TIME: Health - February 27, 2021 Category: Consumer Health News Authors: Alice Park Tags: Uncategorized COVID-19 Source Type: news

NEOMED researcher awarded $2.18 million NIH grant for first human tinnitus treatment
(Northeast Ohio Medical University) NEOMED researcher and professor of anatomy and neurobiology Jianxin Bao, Ph.D., has received a federal grant to produce the first human treatment for tinnitus, a disruptive hearing impairment marked by the perception of ringing or buzzing in one or both ears.Dr. Bao will serve as principal investigator on a research proposal that will receive a Small Business Innovation Research Grant (SBIR) totaling $2.18 million from the National Institute on Deafness and Other Communications Disorders.
Source: EurekAlert! - Social and Behavioral Science - July 16, 2020 Category: International Medicine & Public Health Source Type: news

A proof-of-concept study of the benefits of a single-session of tinnitus instruction and counselling with homework on tinnitus
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Source: International Journal of Audiology - February 4, 2020 Category: Audiology Authors: Grant D. Searchfield Monica Boone Johanna Bensam Mithila Durai Shirley-Anne Hodgson Tania Linford Donald Vogel Source Type: research

Role of the Department of Defense Hearing Center of Excellence in Studying the Treatment of Tinnitus
Against poor odds, Formby and colleagues managed to receive federal grant funding for a multisite clinical trial, to access and convince military investigators to join in this trial, to select rigorous measures and methods when no objective tinnitus measurement exists, and to gain approvals from all levels of regulatory and local command authority oversight bodies across 6 military treatment facilities before they could start their effort to complete the Tinnitus Retraining Therapy Trial (TRTT), described by Scherer and Formby in this issue ofJAMA Otolaryngology –Head& Neck Surgery. In just shy of 20 years from the t...
Source: JAMA Otolaryngology - Head and Neck Surgery - May 23, 2019 Category: ENT & OMF Source Type: research

Crystal Structure of the Monomeric Extracellular Domain of α9 Nicotinic Receptor Subunit in Complex With α-Conotoxin RgIA: Molecular Dynamics Insights Into RgIA Binding to α9α10 Nicotinic Receptors
Conclusion The first crystal structure of a human nAChR domain with an α-Ctx is presented. The structure revealed the interactions between α-Ctx RgIA and the (+) side of neuronal nAChR α9-ECD in high detail. Based on the structure of this complex, models of human α9α10 nAChR ECD with fully formed binding sites were constructed with RgIA bound to each of them. Our MD simulations suggest that the favorable binding site of RgIA in the human α9α10 nAChR ECD consists of either α9 or α10 subunits as the (+) side and of an adjacent α9 rather than α10 su...
Source: Frontiers in Pharmacology - April 30, 2019 Category: Drugs & Pharmacology Source Type: research

Clinical Imaging Findings of Vestibular Aqueduct Trauma in a Patient With Posttraumatic Meniere's Syndrome
In conclusion, for the radiological assessment of TB fractures, the entire VA should be regarded as a part of the otic capsule, and delayed inner ear sequelae should be anticipated for retrolabyrinthine fracture lines that course into or through the VA. When considering treatment options in cases similar to the present, our findings suggest that surgical interventions targeting the eES (ES shunting/decompression procedures (31–33), which are used in MD with the intention to drain the hydropic endolymphatic fluid space, or to improve the fluid resorptive functions of the eES, respectively, most likely cannot work as...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research

Milk Consumption Across Life Periods in Relation to Lower Risk of Nasopharyngeal Carcinoma: A Multicentre Case-Control Study
Conclusion: Consumption of milk across life periods was associated with lower risks of NPC. If confirmed to be causal, this has important implications for dairy product consumption and prevention of NPC. Background The etiology of nasopharyngeal carcinoma (NPC) is unclear, and its male predominance has been linked to sex hormones (1). Dairy products are a source of steroid hormones (2) and contain numerous potential antitumor substances. Using an ecological study design, we found that increasing consumption of dairy products might explain the declining NPC incidence in 48 countries/regions (3, 4). Six case-control s...
Source: Frontiers in Oncology - April 9, 2019 Category: Cancer & Oncology Source Type: research

A feasibility study of predictable and unpredictable surf-like sounds for tinnitus therapy using personal music players
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Source: International Journal of Audiology - May 28, 2018 Category: Audiology Authors: Mithila Durai Kei Kobayashi Grant D. Searchfield Source Type: research

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