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Frequency and Management of Adverse Drug Reactions Among Drug-Resistant Tuberculosis Patients: Analysis From a Prospective Study
Conclusion: The frequency of ADRs was high among the study cohort; however, these were managed effectively. Patients with recognized risk factors for ADRs occurrence need continuous clinical management efforts.
Source: Frontiers in Pharmacology - June 2, 2022 Category: Drugs & Pharmacology Source Type: research

Community based therapy for children with Multidrug-Resistant Tuberculosis in Khyber Pakhtunkhwa Peshawar, Paksitan
Conclusion: MDR-TB among children can be treated successfully in resource-poor settings.
Source: European Respiratory Journal - November 19, 2018 Category: Respiratory Medicine Authors: Javaid, A., Khan, M. A., Khan, M. A. Tags: Tuberculosis Source Type: research

Cycloserine Induced Suicidal Tendencies and Kanamycin Induced Ototoxicity in Indian MDR-TB Patient: A Case Report.
We present a case report on Cycloserine induced Suicidal tendencies and Kanamycin induced decrease in hearing sensation in Indian MDR-TB patient. CASE REPORT: A 55-year-old male patient who was diagnosed with MDR-TB was prescribed with category IV anti-tubercular therapy. Within one month of initiation of therapy, he developed repeated suicidal thoughts, joint pain, restlessness, depression, constipation, insomnia, tinnitus and a decrease in hearing sensation. RESULTS: Cycloserine and kanamycin were closely associated with suicidal tendency and tinnitus followed by decrease in hearing sensations respectively. On ...
Source: Current Drug Safety - June 4, 2018 Category: Drugs & Pharmacology Authors: Jangra MS, Chhabra M Tags: Curr Drug Saf Source Type: research

Spinal primary central nervous system lymphoma: Case report and literature review
Publication date: Available online 21 February 2018 Source:Journal of Clinical Neuroscience Author(s): Li Feng, Dingbang Chen, Hongyan Zhou, Cunzhou Shen, Haiyan Wang, Xunsha Sun, Xiulin Liang, Ling Chen Primary central nervous system lymphoma (PCNSL) is a very rare tumor of increasing incidence. It is often misdiagnosed due to the unspecific presentation or unavailable biopsy, and results in poor prognosis. PCNSL involved the spinal cord is extremely sparse. Here we report a gentleman presented with one-year history of progressive tremor in the left limbs and slight dysarthria as well as three-month history of paraparesi...
Source: Journal of Clinical Neuroscience - February 21, 2018 Category: Neuroscience Source Type: research

The importance of audiometric monitoring in patients with multidrug-resistant tuberculosis
CONCLUSIONS: Evaluations of ototoxicity symptoms were not usually reported in the routine care of patients with MDR-TB. Complaints of tinnitus were associated with amikacin and streptomycin use. These results require confirmation in future studies.
Source: Revista da Sociedade Brasileira de Medicina Tropical - November 6, 2017 Category: Tropical Medicine Source Type: research

Bedaquiline in the multidrug-resistant tuberculosis treatment: Belarus experience
Conclusion Our interim results on safety and effectiveness of bedaquiline-containing regimens in multidrug and extensively drug-resistant tuberculosis (M/XDR-TB) patients are encouraging. They will add value to understanding role and place of this new anti-TB drug in M/XDR-TB treatment.
Source: International Journal of Mycobacteriology - November 22, 2016 Category: Infectious Diseases Source Type: research

Differences in VigiBase ® reporting of aminoglycoside and capreomycin‐suspected ototoxicity during tuberculosis treatment
ConclusionSpontaneous reporting of deafness cases within VigiBase® was most disproportionately associated with amikacin use, followed by kanamycin. There were regional variations in the global reporting of ototoxicity. These findings should be verified through a follow up study. Copyright © 2016 John Wiley & Sons, Ltd.
Source: Pharmacoepidemiology and Drug Safety - November 19, 2016 Category: Drugs & Pharmacology Authors: Evans L. Sagwa, Patrick C. Souverein, In ês Ribeiro, Hubert G. M. Leufkens, Aukje K. Mantel‐Teeuwisse Tags: Original Report Source Type: research

Poszczepienne gru źlicze zapalenie ucha środkowego i jego powikłania – opis przypadku
Conclusion This case reminds us that correct diagnosis of tuberculosis remains a serious problem despite the long experience and the development of diagnostics and treatment methods. Nowadays we observe the unusual clinical manifestations of the disease (e.g. such as ear pain, tinnitus, rapid hearing loss) more frequently.
Source: Otolaryngologia Polska - July 20, 2016 Category: ENT & OMF Source Type: research

Poszczepienne gruźlicze zapalenie ucha środkowego i jego powikłania – opis przypadku
Conclusion This case reminds us that correct diagnosis of tuberculosis remains a serious problem despite the long experience and the development of diagnostics and treatment methods. Nowadays we observe the unusual clinical manifestations of the disease (e.g. such as ear pain, tinnitus, rapid hearing loss) more frequently.
Source: Otolaryngologia Polska - June 26, 2015 Category: ENT & OMF Source Type: research