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Total 56 results found since Jan 2013.

Comprehensive conservative treatment for multiple metastases of skull osteosarcoma: A case report
ConclusionWe found that multiple conservative treatments, which include Denosumab, Anlotinib and DIA chemotherapy, can improve patients' life quality, and help avoid further osteolytic destruction for patients with skull osteosarcoma and multiple metastases. Its specific mechanism and scope of the application still need to be further studied.
Source: Frontiers in Neurology - January 26, 2023 Category: Neurology Source Type: research

Routine Tests for Hearing Loss in All Cisplatin-Treated Patients Routine Tests for Hearing Loss in All Cisplatin-Treated Patients
More than half of patients treated with cisplatin-based chemotherapy develop hearing loss or tinnitus, which can be devastating, say researchers who urge that all patients should be tested routinely.Medscape Medical News
Source: Medscape Hematology-Oncology Headlines - January 25, 2023 Category: Cancer & Oncology Tags: Hematology-Oncology News Source Type: news

The long-term impacts of hearing loss, tinnitus and poor balance on the quality of life of people living with and beyond cancer after platinum-based chemotherapy: a literature review
ConclusionsOtotoxicity has a negative long-term impact on multiple areas of life for adults and children LWBC. This can compromise their quality of life.Implications for cancer survivorsIncreased awareness, monitoring and education surrounding these issues may lead to earlier intervention and better management of ototoxicity, enhancing the quality of life of people LWBC.
Source: Journal of Cancer Survivorship - January 13, 2023 Category: Cancer & Oncology Source Type: research

Prevalence and risk factors for ototoxicity after cisplatin-based chemotherapy
ConclusionsOtotoxicity risk factors included age, cisplatin dose, cardiovascular risk factors, and family history of hearing loss. Three of four TC survivors report some type of ototoxicity; thus, follow-up of cisplatin-treated survivors should include routine assessment for ototoxicity with provision of indicated treatments.Implications for Cancer SurvivorsSurvivors should be aware of risk factors associated with ototoxicity. Referrals to audiologists before, during, and after cisplatin treatment is recommended.
Source: Journal of Cancer Survivorship - January 13, 2023 Category: Cancer & Oncology Source Type: research

Risk factors associated with cisplatin ‐induced ototoxicity in Japanese patients with solid tumors
ConclusionNo patient discontinued treatment owing to hearing impairment. The total cisplatin dose was considered related to post-treatment hearing impairment frequency in Japanese patients. However, routine audiometric monitoring is recommended during high-dose cisplatin-based chemotherapy.
Source: Cancer Medicine - December 26, 2022 Category: Cancer & Oncology Authors: Hideaki Okada, Koichi Kitagawa Tags: RESEARCH ARTICLE Source Type: research

Nasopharyngeal Metastasis from Breast Carcinoma: A Case Report and a Review of the Literature
We report the case of a 50-year-old woman with a history of a confirmed breast carcinoma under chemotherapy who presented to our department with a unilateral hearing loss and tinnitus. Nasal endoscopy revealed a small bulging mass at the posterior wall of the nasopharynx. The biopsy of the lesion showed an infiltration of the nasopharyngeal mucosa by a mammary adenocarcinoma that was positive for estrogen and progesterone receptors and negative for human epidermal growth factor receptor 2. Computed tomography scan revealed a thickening of the nasopharyngeal mucosa, a pleural and pericardial effusion and diffused secondary ...
Source: Ear, Nose and Throat Journal - August 9, 2022 Category: ENT & OMF Authors: Moncef Sellami Souha Kallel Mariam Ben Ayed Manel Mellouli Tahya Sellami Boudawara Malek Mnejja Bouthaina Hammami Imen Achour Ilhem Charfeddine Source Type: research

Hearing Loss, Tinnitus Can Strike Cancer Survivors
THURSDAY, Aug. 4, 2022 -- People who ’ve had chemotherapy to treat a range of common cancers should also have a hearing test. In a new study of 273 cancer survivors, researchers found more than half experienced significant hearing loss even if they...
Source: Drugs.com - Daily MedNews - August 4, 2022 Category: General Medicine Source Type: news

Cancers, Vol. 14, Pages 3422: Definition of an Normal Tissue Complication Probability Model for the Inner Ear in Definitive Radiochemotherapy of Nasopharynx Carcinoma
Conclusion: There is a sigmoidal relation between radiation dose and incidence of inner ear toxicities. Dose constraints for the inner ear of <44 Gy (Dmean) or <58 Gy (Dmax) are suggested to limit the probability of inner ear toxicity <25%.
Source: Cancers - July 14, 2022 Category: Cancer & Oncology Authors: Leonie Peuker Daniel Rolf Michael Oertel Alexander Peuker Sergiu Scobioala Dominik Hering Claudia Rudack Uwe Haverkamp Hans Theodor Eich Tags: Article Source Type: research

Ototoxicity After Cisplatin-Based Chemotherapy: Factors Associated With Discrepancies Between Patient-Reported Outcomes and Audiometric Assessments
Objectives: To provide new information on factors associated with discrepancies between patient-reported and audiometrically defined hearing loss (HL) in adult-onset cancer survivors after cisplatin-based chemotherapy (CBCT) and to comprehensively investigate risk factors associated with audiometrically defined HL. Design: A total of 1410 testicular cancer survivors (TCS) ≥6 months post-CBCT underwent comprehensive audiometric assessments (0.25 to 12 kHz) and completed questionnaires. HL severity was defined using American Speech-Language-Hearing Association criteria. Multivariable multinomial regression ide...
Source: Ear and Hearing - April 17, 2022 Category: Audiology Tags: Research Articles Source Type: research

Pharmacogenomics of cisplatin ‐induced neurotoxicities: Hearing loss, tinnitus, and peripheral sensory neuropathy
ConclusionsGenetics variants inTXNRD1 and WNT8A are notable risk factors for hearing loss and tinnitus, respectively. Future studies should investigate these genes and if replicated, identify their potential impact on preventive strategies.
Source: Cancer Medicine - March 24, 2022 Category: Cancer & Oncology Authors: Xindi Zhang, Matthew R. Trendowski, Emma Wilkinson, Mohammad Shahbazi, Paul C. Dinh, Megan M. Shuey, Regeneron Genetics Center, Darren R. Feldman, Robert J. Hamilton, David J. Vaughn, Chunkit Fung, Christian Kollmannsberger, Robert Huddart, N Tags: RESEARCH ARTICLE Source Type: research

The impact of chemotherapy-induced inner ear damage on quality of life in cancer survivors: a qualitative study
ConclusionsOtotoxicity can have a negative impact on QoL, specifically on social life and the fear of hearing loss and/or tinnitus worsening. There are opportunities for increased awareness by patients and clinicians, including improved information sources, and hearing monitoring not only  for those undergoing platinum-based chemotherapy but many others surviving after treatment for cancer.Implications for Cancer SurvivorsBetter monitoring of hearing and information about ototoxicity during chemotherapy could potentially reduce the fear of the symptoms of ototoxicity worsening. Furthermore, hearing monitoring would facil...
Source: Journal of Cancer Survivorship - August 16, 2021 Category: Cancer & Oncology Source Type: research

Macrolide-associated ototoxicity: a cross-sectional and longitudinal study to assess the association of macrolide use with tinnitus and hearing loss
ConclusionsMacrolide use was significantly associated with both prevalent and incident tinnitus. Macrolide-associated tinnitus was likely cumulative dose-dependent.
Source: Journal of Antimicrobial Chemotherapy - July 27, 2021 Category: Microbiology Source Type: research

Speech perception 30 years after cisplatin-based chemotherapy in adults: limited clinical relevance of long-term ototoxicity?
CONCLUSIONS: Cisplatin causes high-frequency hearing loss, but speech perception tests performed both in quiet and in background noise 30 years post-treatment indicate that the clinical relevance is limited for most patients. Few patients develop severe hearing loss that requires rehabilitation but it is important to identify these patients. Self-reported hearing loss and tinnitus were more common among Cases compared with Controls.PMID:33617403 | DOI:10.1080/0284186X.2021.1887514
Source: Acta Oncologica - February 22, 2021 Category: Cancer & Oncology Authors: J Skalleberg M Myhrum M C Sm åstuen T A Osnes S D Foss å M Bunne Source Type: research

Why Do We Dream? A New Theory on How It Protects Our Brains
When he was two years old, Ben stopped seeing out of his left eye. His mother took him to the doctor and soon discovered he had retinal cancer in both eyes. After chemotherapy and radiation failed, surgeons removed both his eyes. For Ben, vision was gone forever. But by the time he was seven years old, he had devised a technique for decoding the world around him: he clicked with his mouth and listened for the returning echoes. This method enabled Ben to determine the locations of open doorways, people, parked cars, garbage cans, and so on. He was echolocating: bouncing his sound waves off objects in the environment and cat...
Source: TIME: Science - December 29, 2020 Category: Science Authors: David Eagleman and Don Vaughn Tags: Uncategorized Source Type: news