Genes, Vol. 14, Pages 1847: Comparative Studies on Duplicated foxl2 Paralogs in Spotted Knifejaw Oplegnathus punctatus Show Functional Diversification
In this study, two foxl2 paralogs, foxl2 and foxl2l, were identified in the transcriptome of spotted knifejaw (Oplegnathus punctatus), which had varying expressions in the gonads. The foxl2 was expressed higher in the ovary, while foxl2l was expressed higher in the testis. Phylogenetic reconstruction, synteny analysis, and the molecular evolution test confirmed that foxl2 and foxl2l likely originated from the first two WGD. The expression patterns test using qRT-PCR and ISH as well as motif scan analysis revealed evidence of potentially functional divergence between the foxl2 and foxl2l paralogs in spotted knifejaw. Our re...
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Xinxin Du Haiyang Yu Yujue Wang Jinxiang Liu Quanqi Zhang Tags: Article Source Type: research

Genes, Vol. 14, Pages 1846: LRP5, Bone Mass Polymorphisms and Skeletal Disorders
K. Aaron The formation and maintenance of the gross structure and microarchitecture of the human skeleton require the concerted functioning of a plethora of morphogenic signaling processes. Through recent discoveries in the field of genetics, numerous genotypic variants have been implicated in pathologic skeletal phenotypes and disorders arising from the disturbance of one or more of these processes. For example, total loss-of-function variants of LRP5 were found to be the cause of osteoporosis-pseudoglioma syndrome (OPPG). LRP5 encodes for the low-density lipoprotein receptor-related protein 5, a co-receptor in the c...
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Jake Littman Wentian Yang Jon Olansen Chanika Phornphutkul Roy K. Aaron Tags: Review Source Type: research

Genes, Vol. 14, Pages 1845: INPP5D/SHIP1: Expression, Regulation and Roles in Alzheimer & rsquo;s Disease Pathophysiology
Genes, Vol. 14, Pages 1845: INPP5D/SHIP1: Expression, Regulation and Roles in Alzheimer’s Disease Pathophysiology Genes doi: 10.3390/genes14101845 Authors: Edward O. Olufunmilayo R. M. Damian Holsinger Alzheimer’s disease (AD) is the most common form of dementia, accounting for approximately 38.5 million cases of all-cause dementia. Over 60% of these individuals live in low- and middle-income countries and are the worst affected, especially by its deleterious effects on the productivity of both patients and caregivers. Numerous risk factors for the disease have been identified and our unde...
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Edward O. Olufunmilayo R. M. Damian Holsinger Tags: Review Source Type: research

Genes, Vol. 14, Pages 1844: Association between Gastric Cancer and 12 Autoimmune Diseases: A Mendelian Randomization Study
Conclusion: Our study did not find a genetic causal relationship between susceptibility to these autoimmune diseases and GC, which suggests that unmeasured confounders (e.g., inflammatory processes) or shared genetic architecture may be responsible for the reported epidemiologic associations. Further studies of ancestral diversity are warranted to validate such causal associations.
Source: Genes - September 23, 2023 Category: Genetics & Stem Cells Authors: Qi Wei Ziyu Wang Xuanyu Liu Haibin Liang Lei Chen Tags: Article Source Type: research

Semi-automating abstract screening with a natural language model pretrained on biomedical literature
AbstractWe demonstrate the performance and workload impact of incorporating a natural language model, pretrained on citations of biomedical literature, on a workflow of abstract screening for studies on prognostic factors in end-stage lung disease. The model was optimized on one-third of the abstracts, and model performance on the remaining abstracts was reported. Performance of the model, in terms of sensitivity, precision, F1 and inter-rater agreement, was moderate in comparison with other published models. However, incorporating it into the screening workflow, with the second reviewer screening only abstracts with confl...
Source: Systematic Reviews - September 23, 2023 Category: International Medicine & Public Health Source Type: research

Professional identity formation among undergraduate pre-medical students: a scoping review protocol
The objective of this scoping review is to systematically map the literature on professional identity formation among undergraduate pre-medical students.MethodsThis review protocol has been designed following the Arksey and O ’Malley framework. We will search MEDLINE, CINAHL, Embase, and Scopus, as well as relevant grey literature, conference proceedings, and citations of selected articles. Inclusion criteria are articles (1) written in the English language, (2) involving undergraduate pre-medical students in the USA a nd Canada, and (3) containing original data about professional identity formation. Two independent revi...
Source: Systematic Reviews - September 23, 2023 Category: International Medicine & Public Health Source Type: research

Artificial intelligence to identify fractures on pediatric and young adult upper extremity radiographs
ConclusionAn object detection AI model identified pediatric upper extremity fractures with high accuracy.Graphical abstract
Source: Pediatric Radiology - September 23, 2023 Category: Radiology Source Type: research

Predictive value of chemokines (CCL 2) in bronchoalveolar lavage fluid for refractory mycoplasma pneumonia in children
ConclusionThe level of CCL2 in BALF was high in children with MPP and had a high predictive value for RMPP. CCL2 can be used as one of the biomarkers for predicting RMPP.
Source: Italian Journal of Pediatrics - September 23, 2023 Category: Pediatrics Source Type: research

Molecules, Vol. 28, Pages 6777: 2-Pyridinecarboxaldehyde-Modified Chitosan & ndash;Silver Complexes: Optimized Preparation, Characterization, and Antibacterial Activity
In this study, 2-pyridinecarboxaldehyde (PCA) was grafted onto chitosan (CS) and the modified CS coordinated with silver ions to prepare PCA-CS-Ag complexes with antibacterial activity. To obtain complexes with a high silver content, the preparation process was optimized using single-factor experiments and response surface methodology. Under the optimal preparation conditions (an additional amount of silver nitrate (58 mg), a solution pH of 3.9, and a reaction temperature of 69 °C), the silver content of the PCA-CS-Ag complex reached 13.27 mg/g. The structure of the PCA-CS-Ag complex was subsequently verified u...
Source: Molecules - September 23, 2023 Category: Chemistry Authors: Zhaoyu Zhang Yurong Zhao Zhang Hu Zhenyu Si Ziming Yang Tags: Article Source Type: research

Linear and wavelet analysis of aerosol optical depth (AOD) and prevailing meteorological factors during summer (2003 –2016) over Turkey using Remote Sensing
In this study, a notable variation was observed in the space–time dynamics between MODIS and MISR datasets which can be used for future studies that attempt to analyze the relationship between AOD and covariates during the summer season.
Source: Air Quality, Atmosphere and Health - September 23, 2023 Category: Environmental Health Source Type: research

Correction to: Detection of the fungicide transformation product 4-hydroxychlorothalonil in serum of pregnant women from Sweden and Costa Rica
Journal of Exposure Science & Environmental Epidemiology, Published online: 23 September 2023; doi:10.1038/s41370-023-00604-3Correction to: Detection of the fungicide transformation product 4-hydroxychlorothalonil in serum of pregnant women from Sweden and Costa Rica
Source: Journal of Exposure Science and Environmental Epidemiology - September 23, 2023 Category: Epidemiology Authors: Annette M. Krais Berna van Wendel de Joode Emelie Rietz Liljedahl Annelise J. Blomberg Anna R önnholm Marie Bengtsson Juan Camilo Cano Jane A. Hoppin Margareta Littorin Christel Nielsen Christian H. Lindh Source Type: research

IJERPH, Vol. 20, Pages 6812: Coping, Supports and Moral Injury: Spiritual Well-Being and Organizational Support Are Associated with Reduced Moral Injury in Canadian Healthcare Providers during the COVID-19 Pandemic
be Margaret C. McKinnon Healthcare providers (HCPs) have described the onset of shame- and trust-violation-related moral injuries (MI) throughout the COVID-19 pandemic. Previous research suggests that HCPs may turn to various coping methods and supports, such as spirituality/religiosity, substance use, friends/family or organizational support, to manage workplace stress. It remains unknown, however, if similar coping methods and supports are associated with MI among this population. We explored associations between MI (including the shame and trust-violation presentations individually) and coping methods and supports...
Source: International Journal of Environmental Research and Public Health - September 23, 2023 Category: Environmental Health Authors: Andrea M. D ’Alessandro-Lowe Mauda Karram Kim Ritchie Andrea Brown Heather Millman Emily Sullo Yuanxin Xue Mina Pichtikova Hugo Schielke Ann Malain Charlene O ’Connor Ruth Lanius Randi E. McCabe Margaret C. McKinnon Tags: Article Source Type: research

IJERPH, Vol. 20, Pages 6811: Preventing Perinatal Depression: Cultural Adaptation of the Mothers and Babies Course in Kenya and Tanzania
John Hembling Pregnant women and mothers in sub-Saharan Africa are at high risk for perinatal depression, warranting a need to develop culturally tailored interventions to prevent perinatal depression. This paper documents the process of adapting an evidence-based preventive intervention developed in the United States, the Mothers and Babies Course (MBC), to fit the contexts of rural pregnant women and mothers of young children in Kenya and Tanzania using the updated Framework for Reporting Adaptations and Modifications-Enhanced (FRAME). Data from informant interviews and field observations from the planning and impl...
Source: International Journal of Environmental Research and Public Health - September 23, 2023 Category: Environmental Health Authors: Huynh-Nhu Le Elena McEwan Maureen Kapiyo Fidelis Muthoni Tobias Opiyo Kantoniony M. Rabemananjara Shannon Senefeld John Hembling Tags: Article Source Type: research

IJERPH, Vol. 20, Pages 6810: School Memories about Homophobic Bullying: A Study Based on Cultural-Historical Psychology
This study is based on cultural-historical psychology in intersection with gender and sexuality studies. In-depth online interviews were conducted with three young subjects who identified themselves as non-heterosexual. The interviews were recorded, transcribed, and analyzed through the analytical discourse tool defined as Nuclei of Meanings. The results were organized in two topics of discussion: (a) the problems associated with non-heterosexual identity in schools; (b) the search for other ways of experiencing sexual identity in school. Throughout the article, reflections were held about the challenges participants had t...
Source: International Journal of Environmental Research and Public Health - September 23, 2023 Category: Environmental Health Authors: R ômulo Lopes da Silva Vera Lucia Trevisan de Souza Tags: Article Source Type: research

Differential behavioral aging trajectories according to body size, expected lifespan, and head shape in dogs
We examined the effect of expected lifespan and three related factors (body size, head shape, and purebred status) on the age trajectory of various behavioral characteristics and the prevalence of canine cognitive dysfunction (CCD). Our findings reveal that, although age-related decline in most behavioral characteristics began around 10.5  years of age, the proportion of dogs considered “old” by their owners began to increase uniformly around 6 years of age. From the investigated factors, only body size had a systematic, although not gradual, impact on the aging trajectories of all behavioral characteristics. Dogs we...
Source: AGE - September 23, 2023 Category: Geriatrics Source Type: research

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