Catalyzing an improved arterial bypass graft
(University of Pittsburgh) A successful small-diameter tissue-engineered vascular graft (TEVG) will grow and remodel into a native-like artery that can save a life. A team led by Pitt's David Vorp received a $1.1M award from the NIH to optimize this emerging technology for cardiovascular disease. They will examine the best combination(s) of active " payload " and scaffold to develop a feasible alternative to the decades-old practice of using vessels harvested from a patient's own chest or leg.
Source: EurekAlert! - Medicine and Health - September 25, 2020 Category: International Medicine & Public Health Source Type: news

Cancer's ongoing evolution
(Max Delbr ü ck Center for Molecular Medicine in the Helmholtz Association) A new algorithmic approach reveals individual tumors continue to evolve and remodel their genomes, and this occurs across a broad range of tumor types. Identifying changes that benefit tumors and help them metastasize could help with future treatments.
Source: EurekAlert! - Cancer - September 2, 2020 Category: Cancer & Oncology Source Type: news

A synthetic synaptic organizer protein restores glutamatergic neuronal circuits
Neuronal synapses undergo structural and functional changes throughout life, which are essential for nervous system physiology. However, these changes may also perturb the excitatory–inhibitory neurotransmission balance and trigger neuropsychiatric and neurological disorders. Molecular tools to restore this balance are highly desirable. Here, we designed and characterized CPTX, a synthetic synaptic organizer combining structural elements from cerebellin-1 and neuronal pentraxin-1. CPTX can interact with presynaptic neurexins and postsynaptic AMPA-type ionotropic glutamate receptors and induced the formation of excita...
Source: ScienceNOW - August 26, 2020 Category: Science Authors: Suzuki, K., Elegheert, J., Song, I., Sasakura, H., Senkov, O., Matsuda, K., Kakegawa, W., Clayton, A. J., Chang, V. T., Ferrer-Ferrer, M., Miura, E., Kaushik, R., Ikeno, M., Morioka, Y., Takeuchi, Y., Shimada, T., Otsuka, S., Stoyanov, S., Watanabe, M., T Tags: Biochemistry, Neuroscience, Online Only r-articles Source Type: news

Plasticity may make neurons vulnerable to Alzheimer's disease
(Simons Foundation) Some neuron types are particularly prone to Alzheimer's, and a new study suggests that those neurons are vulnerable because they regularly remodel. The work is the first to track the progression of Alzheimer's at the genetic and molecular levels within the neurons most susceptible to the disease. The findings suggest that aging and the accumulation amyloid-beta can cause the remodeling process to go awry, creating tangles of tau proteins that lead to neuron death.
Source: EurekAlert! - Medicine and Health - June 29, 2020 Category: International Medicine & Public Health Source Type: news

Molecules that reduce 'bad' gut bacteria reverse narrowing of arteries in animal study
(Scripps Research Institute) Scientists at Scripps Research have developed molecules that can remodel the bacterial population of intestines to a healthier state. They also have shown--through experiments in mice--that this approach reduces cholesterol levels and strongly inhibits the thickened-artery condition known as atherosclerosis.
Source: EurekAlert! - Medicine and Health - June 15, 2020 Category: International Medicine & Public Health Source Type: news

ABQ contractor to remodel Arizona facility for Covid-19 patients
As it wraps up work on one alternative care facility for Covid-19 patients, Albuquerque-based Weil Construction Inc. is working on another one — this time in Arizona. Chris Weil, president and owner of Weil Construction, said his company partnered again with the United States Army Corps of Engineers by retrofitting the Chinle Community Center in Chinle, Arizona for non-acute infectious Covid-19 patients, meaning it will treat patients who have the virus, but have not reached the more serious…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - April 28, 2020 Category: Pharmaceuticals Authors: Ron Davis Source Type: news

ABQ construction company, Army Corps of Engineers to remodel old hospital for COVID-19 patients
New Mexico health officials anticipate a need for more hospital beds to care for an increasing number of patients infected with the COVID-19 virus. To meet this need, Albuquerque-based Weil Construction Inc. will partner with the Albuquerque District of the Army Corps of Engineers to begin "emergency construction" at the old Lovelace hospital at the Gibson Medical Center. Work is scheduled to be completed in 14 days, according to a Weil Construction news release. The alternate care facility for…
Source: bizjournals.com Health Care:Pharmaceuticals headlines - April 14, 2020 Category: Pharmaceuticals Authors: Ron Davis Source Type: news

DNA riddle unravelled: How cells access data from 'genetic cotton reels'
(University of Sydney) With so much genetic information packed in such a tiny space, how cells access DNA when it needs it is something of a mystery. Research published today by Professor Joel Mackay and colleagues has revealed the role played by motor protein CHD4 that allows the DNA to remodel when the information is needed -- and it will help us understand diseases connected to when that process goes wrong.
Source: EurekAlert! - Biology - March 26, 2020 Category: Biology Source Type: news

BioVentrix Scores ‘High Priority’ Reimbursement in Germany
BioVentrix has received the renewal of the highest priority reimbursement in Germany for its transcatheter device for left ventricular remodeling after a heart attack. The San Ramon, CA-based company said it has achieved NUB Status 1 designation from InEk, the German Institute for Hospital Remuneration for the Revivent TC TransCatheter Ventricular Enhancement System. The NUB process enables participating German hospitals to receive full reimbursement plus a supplemental payment when utilizing groundbreaking medical technologies not listed in the existing German healthcare system. NUB Status 1 was only assigned to a handful...
Source: MDDI - February 6, 2020 Category: Medical Devices Authors: Omar Ford Tags: Cardiovascular Regulatory and Compliance Source Type: news

Brain tumors remodel neuronal synapses to promote growth
(Baylor College of Medicine) Scientists discovered that glioma, a lethal form of brain cancer, alters the activity of neighboring neurons, accelerating a vicious cycle that drives tumor-associated epilepsy and tumor progression.
Source: EurekAlert! - Cancer - January 29, 2020 Category: Cancer & Oncology Source Type: news

In mice, alcohol dependence results in brain-wide remodeling of functional architecture
(University of California - San Diego) Using novel imaging technologies, researchers produce first whole-brain atlas at single-cell resolution, revealing how alcohol addiction and abstinence remodel neural physiology and function in mice.
Source: EurekAlert! - Medicine and Health - January 14, 2020 Category: International Medicine & Public Health Source Type: news

BioVentrix Has Developed a Unique Way to Improve Heart Functionality
BioVentrix is getting closer to bringing its transcatheter-based structural cardiovascular device to treat heart failure to the U.S. The private company announced receiving FDA breakthrough device designation for the Revivent TC Transcatheter Ventricular Enhancement System. This designation can help put San Ramon, CA-based BioVentrix on a faster path to obtaining FDA approval. The firm’s Revivent TC System is used in the Less Invasive Ventricular Enhancement (LIVE) procedure, to exclude scar tissue on the left ventricle that has resulted from a heart attack, so the healthy portion of the heart can functio...
Source: MDDI - November 20, 2019 Category: Medical Devices Authors: Omar Ford Tags: Cardiovascular Source Type: news

After A Rural Hospital Closes, Delays In Emergency Care Cost Patients Dearly
While rural Fort Scott, Kansas found another hospital to reopen its ER for 2 years after its hospital closed, an 18-day ER remodel left 80 patients to travel more than 1,300 miles for care. The county took over emergency medical services, but is not sure how they will afford ambulance upkeep and relies on air ambulances for time-sensitive emergencies. Part 3 of the "No Mercy" series addressing the impact of a hospital closure on a rural community.
Source: News stories via the Rural Assistance Center - August 19, 2019 Category: Rural Health Source Type: news

Care homes forced to drop nurse provision amid staffing crisis
More and more nursing homes are being forced to shut or remodel as residential homes due to a “chronic” shortage of nurses in the independent sector, leaders have warned.
Source: Nursing Times - August 15, 2019 Category: Nursing Source Type: news

UCLA dental clinic shines as beacon of health and dignity
Though we now think of Venice as a gentrifying playground for tourists and tech workers, in the 50s and 60s it was so infested with poverty, it was known as the “Slum by the Sea.”With an overwhelming majority of the population just trying to pay for the bare necessities, Venice residents and the surrounding community were matching victims of neglect. By 1967, a group of young community organizers — called the Venice Health Council — mobilized in response. The council hoped to capitalize on government funding and the opening of a community clinic in Watts (which during the riots two years before had seen six days of...
Source: UCLA Newsroom: Health Sciences - July 10, 2019 Category: Universities & Medical Training Source Type: news

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