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Esotropia surgery in children with Down syndrome
Conclusions: In this patient cohort, good surgical outcomes were achieved in children with esotropia and Down syndrome compared with those with esotropia but without Down syndrome using the same surgical technique.
Source: Journal of AAPOS - October 1, 2013 Category: Opthalmology Authors: Claudio I. Perez, Francisca Zuazo, Mario T. Zanolli, Juan P. Guerra, Olga Acuña, Hernan Iturriaga Tags: Major Articles Source Type: research
The relationship between matrix metalloproteinases (MMP‐3, ‐8, ‐9) in serum and peripheral lymphocytes (CD8+, CD56+) in Down syndrome children with gingivitis
ConclusionsThe positive relationship of serum MMP‐3, ‐8 and ‐9 with immune cells in children with Down syndrome may facilitate migration of CD8+ T cells and CD56+ NK cells into the periodontal tissue, which may contribute to the increased degradation of periodontal tissue in individuals with Down syndrome.
Source: Journal of Periodontal Research - December 1, 2013 Category: Dentistry Authors: G. Tsilingaridis, T. Yucel‐Lindberg, H. Concha Quezada, T. Modéer Tags: Original Article Source Type: research
Experience of women with a school-age child with down syndrome
The aim of this study was to understand the experience and expectations of women having a school-age child with Down Syndrome. Participants were ten mothers of children with this syndrome who attended a mainstream school and were interviewed in June 2011. The following categories emerged from the testimonies: 'coping with challenges', 'search for balance', 'future projection of the child with Down Syndrome' and 'conciliation among being a woman, worker and mother to a child with Down Syndrome'. The women feel overburdened by the need to conciliate multiple roles. They are concerned with not knowing who will take care of th...
Source: Texto e Contexto - Enfermagem - April 11, 2014 Category: Global & Universal Source Type: research
Screening for Obstructive Sleep Apnea in Children with Down Syndrome
Conclusion: Compared with closely matched typically developing children with OSA of comparable severity, children with Down syndrome had a similar symptom profile and slightly worse gas exchange. Referred children with Down syndrome had more severe OSA than referred typically developing children, suggesting a relative reluctance by parents or doctors to investigate symptoms of OSA in children with Down syndrome. These findings highlight the need for formal screening tools for OSA in children with Down syndrome to improve detection of the condition in this high-risk group.
Source: The Journal of Pediatrics - March 27, 2014 Category: Pediatrics Authors: Sandi C. Lin, Margot J. Davey, Rosemary S.C. Horne, Gillian M. Nixon Tags: Original Articles Source Type: research
Major congenital anomalies in babies born with Down syndrome: A EUROCAT population‐based registry study
This study aimed to determine if the introduction of these screening programs and the subsequent termination of prenatally detected pregnancies were associated with any decline in the prevalence of additional anomalies in babies born with Down syndrome. The study sample consisted of 7,044 live births and fetal deaths with Down syndrome registered in 28 European population‐based congenital anomaly registries covering seven million births during 2000–2010. Overall, 43.6% (95% CI: 42.4–44.7%) of births with Down syndrome had a cardiac anomaly and 15.0% (14.2–15.8%) had a non‐cardiac anomaly. Female babies with Down ...
Source: American Journal of Medical Genetics Part A - September 24, 2014 Category: Genetics & Stem Cells Authors: Joan K. Morris, Ester Garne, Diana Wellesley, Marie‐Claude Addor, Larraitz Arriola, Ingeborg Barisic, Judit Beres, Fabrizio Bianchi, Judith Budd, Carlos Matias Dias, Miriam Gatt, Kari Klungsoyr, Babak Khoshnood, Anna Latos‐Bielenska, Carmel Mullaney, Tags: Research Article Source Type: research
The use of mouse models for understanding the biology of down syndrome and aging.
Authors: Vacano GN, Duval N, Patterson D
Abstract
Down syndrome is a complex condition caused by trisomy of human chromosome 21. The biology of aging may be different in individuals with Down syndrome; this is not well understood in any organism. Because of its complexity, many aspects of Down syndrome must be studied either in humans or in animal models. Studies in humans are essential but are limited for ethical and practical reasons. Fortunately, genetically altered mice can serve as extremely useful models of Down syndrome, and progress in their production and analysis has been remarkable. Here, we describe var...
Source: Current Gerontology and Geriatrics Research - November 25, 2014 Category: Geriatrics Tags: Curr Gerontol Geriatr Res Source Type: research
Brains of people with Down syndrome age faster, UCLA study discovers
FINDINGS
A new UCLA study is the first to demonstrate that Down syndrome accelerates aging in different parts of the body. The researchers showed that the biological age of brain tissue from someone with Down syndrome appeared 11 years older than the person’s chronological age. Similarly, the biological age of blood tissue was nearly five years older than the person’s chronological age. The UCLA team will next test tissue samples from teens with Down syndrome to pinpoint when aging speeds up in people with the condition.
IMPACT
The findings could explain why people with Down syndrome face a six times higher risk of de...
Source: UCLA Newsroom: Health Sciences - February 18, 2015 Category: Universities & Medical Training Source Type: news
Prosodic skills in children with Down syndrome and in typically developing children.
CONCLUSIONS & IMPLICATIONS: The findings are discussed considering the effects of social experience on the utterance prosodic realization.
PMID: 26123669 [PubMed - as supplied by publisher]
Source: International Journal of Language and Communication Disorders - June 30, 2015 Category: Speech Therapy Authors: Zampini L, Fasolo M, Spinelli M, Zanchi P, Suttora C, Salerni N Tags: Int J Lang Commun Disord Source Type: research
Cross-syndrome comparison of real-world executive functioning and problem solving using a new problem-solving questionnaire
Conclusion Results suggest that individuals with Down syndrome tend to use compensatory strategies for problem solving (asking for help and potentially, keeping items well ordered), while for individuals with Williams syndrome, emotional reactions disrupt their problem-solving skills. This paper highlights the importance of identifying syndrome-specific problem-solving strengths and difficulties to improve effective functioning in everyday life.
Source: Research in Developmental Disabilities - August 10, 2016 Category: Disability Source Type: research
What Do Parents of Children with Down Syndrome Think about Non-Invasive Prenatal Testing (NIPT)?
This study explores the attitudes of parents of children with Down syndrome towards non-invasive prenatal testing (NIPT) and widening the scope of prenatal screening. Three focus groups (n = 16) and eleven individual interviews with Dutch parents (and two relatives) of children with Down syndrome were conducted. Safety, accuracy and earlier testing were seen as the advantages of NIPT. Some participants were critical about the practice of screening for Down syndrome, but acknowledge d that NIPT enables people to know whether the fetus is affected and to prepare without risking miscarriage. Many feared uncritical use of NI...
Source: Journal of Genetic Counseling - September 12, 2016 Category: Genetics & Stem Cells Source Type: research
Coenzyme Q10 and pro-inflammatory markers in children with Down syndrome: clinical and biochemical aspects.
CONCLUSION: IL-6 and TNFα levels in young children with Down syndrome may be used as biomarkers reflecting the neurodegenerative process in them. Coenzyme Q10 might have a role as a good supplement in young children with Down syndrome to ameliorate the neurological symptoms.
PMID: 27770619 [PubMed - as supplied by publisher]
Source: Jornal de Pediatria - October 18, 2016 Category: Pediatrics Authors: Zaki ME, El-Bassyouni HT, Tosson AM, Youness E, Hussein J Tags: J Pediatr (Rio J) Source Type: research
Relationships between Muscle Architecture of Rectus Femoris and Functional Parameters of Knee Motion in Adults with Down Syndrome.
This study was designed to measure in vivo muscle architecture of the rectus femoris in adults with Down syndrome, testing possible relationships with functional parameters of the knee motion. Ten adults with Down syndrome and ten typically developed participated in the study. Pennation angle and thickness of the rectus femoris and subcutaneous layer of the thigh were measured via ultrasound imaging. Knee kinematics and electromyographic activity of the rectus femoris were recorded during free leg dropping. Muscle thickness was reduced and subcutaneous layer was thicker in persons with Down syndrome with respect to typical...
Source: Biomed Res - December 1, 2016 Category: Research Authors: Valle MS, Casabona A, Micale M, Cioni M Tags: Biomed Res Int Source Type: research
The motor repertoire in 3- to 5-month old infants with Down syndrome
Conclusions and implications The heterogeneity in fidgety movements and MOS add to an understanding of the large variability of the early phenotype of Down syndrome. Studies on the predictive values of the early spontaneous motor repertoire, especially for the cognitive outcome, are warranted. What this paper adds The significance of this exploratory study lies in its minute description of the motor repertoire of infants with Down syndrome aged 3–5 months. Thirty percent of infants with Down syndrome showed age-specific normal fidgety movements. The rate of abnormal fidgety movements (large amplitude, high/slow speed) or...
Source: Research in Developmental Disabilities - June 4, 2017 Category: Disability Source Type: research
Earlier Pulmonary Valve Replacement in Down Syndrome Patients Following Tetralogy of Fallot Repair
AbstractThe association between Down syndrome and pulmonary hypertension could contribute to more severe pulmonary regurgitation after tetralogy of Fallot repair and possibly earlier pulmonary valve replacement. We compared cardiac magnetic resonance measures of pulmonary regurgitation and right ventricular dilation as well as timing of pulmonary valve replacement between those with and without Down syndrome after tetralogy of Fallot repair. Review of our surgical database from 2000 to 2015 identified patients with tetralogy of Fallot with pulmonary stenosis. Those with Down syndrome were compared to those without. The pri...
Source: Mammalian Genome - June 14, 2017 Category: Genetics & Stem Cells Source Type: research
Demographics and co ‐occurring conditions in a clinic‐based cohort with Down syndrome in the United Arab Emirates
This study describes a large hospital‐based group with Down syndrome presenting to a new dedicated Down syndrome clinic in the UAE, highlighting unique demographic and co‐occurring conditions found in that population.
Source: American Journal of Medical Genetics Part A - July 7, 2017 Category: Genetics & Stem Cells Authors: Jennifer Price Corder, Fatima Jaber Sehmi Al Ahbabi, Hind Saif Al Dhaheri, Fares Chedid Tags: ORIGINAL ARTICLE Source Type: research
