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Down syndrome: An integrative review
Publication date: Available online 3 February 2018 Source:Journal of Neonatal Nursing Author(s): Katrina Diamandopoulos, Janet Green Down syndrome is a complex genetic disorder resulting in three copies of chromosome 21. Babies with this genetic disorder will have recognisable characteristic facial features that will differ from one baby to another. They will also have some degree of cognitive impairment and learning difficulties. There are many medical conditions associated with Down syndrome, however, due to recent medical advances there have been improvements in their health and longevity. This has led to a rise in peo...
Source: Journal of Neonatal Nursing - March 5, 2018 Category: Perinatology & Neonatology Source Type: research

Projected number of children with isolated spina bifida or down syndrome in England and Wales by 2020.
This study aimed to estimate the number of children aged 0-15 years living with spina bifida or Down syndrome in England and Wales by 2020. Cases of spina bifida and Down syndrome born during 1998-2013 were identified from the Northern Congenital Abnormality Survey and the National Down Syndrome Cytogenetic Register, respectively. The number of infants born with spina bifida during 1998-2019 were estimated by applying the average prevalence rate in the North of England to actual and projected births in England and Wales. Poisson regression was performed to estimate the number of infants born with Down syndrome in England a...
Source: European Journal of Medical Genetics - May 10, 2018 Category: Genetics & Stem Cells Authors: Best KE, Glinianaia SV, Lingam R, Morris JK, Rankin J Tags: Eur J Med Genet Source Type: research

Down syndrome: An integrative review
Publication date: Available online 3 February 2018Source: Journal of Neonatal NursingAuthor(s): Katrina Diamandopoulos, Janet GreenAbstractDown syndrome is a complex genetic disorder resulting in three copies of chromosome 21. Babies with this genetic disorder will have recognisable characteristic facial features that will differ from one baby to another. They will also have some degree of cognitive impairment and learning difficulties. There are many medical conditions associated with Down syndrome, however, due to recent medical advances there have been improvements in their health and longevity. This has led to a rise i...
Source: Journal of Neonatal Nursing - July 5, 2018 Category: Perinatology & Neonatology Source Type: research

Identification of a thymus microRNA ‑mRNA regulatory network in Down syndrome.
Identification of a thymus microRNA‑mRNA regulatory network in Down syndrome. Mol Med Rep. 2019 Jun 27;: Authors: Chai M, Su L, Hao X, Zhang M, Zheng L, Bi J, Han X, Gao C Abstract The present bioinformatics analysis was performed using a multi‑step approach to identify a microRNA (miR)‑mRNA regulatory network in Down syndrome. miR (GSE69210) and mRNA (GSE70573) data was downloaded and collected from the thymic tissues of both Down syndrome and karyotypically normal subjects and placed in a public repository. Then, weighted gene co‑expression network analysis (WGCNA) was performed to screen for...
Source: Molecular Medicine Reports - July 2, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research

Feeding difficulty and gastrostomy tube placement in infants with Down syndrome
Conclusion: The currently established clinical tools for determining which patients may benefit from radiographic evaluation lack sufficient sensitivity to detect all individuals with feeding difficulty. Due to the high prevalence of abnormal VSS results and high rate of G-tube placement, universal radiographic screening for individuals with Down syndrome could be considered, even in the absence of obvious clinical signs or symptoms. However, determining how to balance this with cost, availability, and radiation exposure may be difficult.What is Known:•Feeding difficulty in children with Down syndrome can lead to signifi...
Source: European Journal of Pediatrics - May 13, 2020 Category: Pediatrics Source Type: research

Mapping the corneal thickness and volume in patients with Down syndrome: a comparative population-based study
Conclusion: Non-keratoconic patients with Down syndrome had thin corneas with a homogeneous distribution. Therefore, the reference ranges of cornea thickness and volume should be re-defined for this patient population.RESUMO Objetivo: Medir a espessura corneana central e perif érica e se4u volume de acordo com a idade e gênero em pacientes com idades entre 10 e 30 anos com síndrome de Down e em indivíduos saudáveis sem síndrome de Down. Métodos: No estudo 202 olhos normais direitos de pacientes com síndrome de Down e 190 olhos direitos de indivíduos sem síndrom e de Down e médias comparadas usando o teste t de a...
Source: Arquivos Brasileiros de Oftalmologia - May 29, 2020 Category: Opthalmology Source Type: research

Thyroid Function in Children with Down Syndrome in the Polish Population: A Case-Control Study.
CONCLUSION: Children with Down syndrome may have increased secretion of TSH, even when thyroid hormone and autoantibodies are normal, suggesting that an isolated increase in TSH does not predispose the patient to the development of thyroid disease. We also recommend that all patients with Down syndrome should be screened for thyroid dysgenesis, since they have thyroid dysfunction more frequently as compared to the general healthy population. PMID: 32536175 [PubMed - in process]
Source: Archives of Iranian Medicine - May 31, 2020 Category: Middle East Health Authors: Zelazowska-Rutkowska B, Jakubiuk-Tomaszuk A, Cylwik B Tags: Arch Iran Med Source Type: research

Researchers Detangle Protein Interaction Implicated in Down Syndrome and Alzheimer ' s
Researchers Detangle Protein Interaction Implicated in Down Syndrome and Alzheimer's New findings by chemists Wolfgang Peti and Rebecca Page provide a foundation to better understand and treat these neurological disorders. Brittany Uhlorn Today BIO5 InstituteNMR_room_PC Wolfgang Peti-web.jpg The powerful biomolecular NMR spectrometers at the University of Arizona have allowed scientists to gain molecular details of the interaction between RCAN1 and calcineurin, two proteins that have long been implicated in Down syndrome and Alzheimer's disease.HealthScience and TechnologyBIO5College of ScienceMedia contact...
Source: The University of Arizona: Health - July 27, 2020 Category: Universities & Medical Training Authors: mittank Source Type: research

IJERPH, Vol. 18, Pages 352: Demographic Assessment of Down syndrome: A Systematic Review
The objective of this study is to assess the evidence about the demographic transformation of the Down Syndrome population, with a specific focus on prenatal testing, and to identify sources frequently used for demographic assessment of Down Syndrome in the world. We reviewed existing studies on demographic transformations in the population with Down Syndrome, specifically birthrate indicators, under the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Statement. The searches were made in Medline (via EBSCO Host), Academic Search Complete (via EBSCO Host), PsycINFO (via EBSCO Host), Web of Scienc...
Source: International Journal of Environmental Research and Public Health - January 5, 2021 Category: Environmental Health Authors: Huete-Garc ía Otaola-Barranquero Tags: Review Source Type: research

Adenovirus Infection in Children with Down Syndrome
CONCLUSIONS: Children with Down syndrome who were hospitalized with adenovirus infection represent a high-risk group and warrant close monitoring. If a vaccine for adenovirus becomes available, children with Down syndrome should be considered as candidates.PMID:34251123
Source: The Israel Medical Association Journal - July 12, 2021 Category: General Medicine Authors: Miri Dotan Elena Zion Haim Ben-Zvi Havatzelet Yarden-Bilavsky Efraim Bilavsky Source Type: research