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Total 981256 results found since Jan 2013.
Tooth wear prevalence in individuals with Down syndrome: a systematic review
ConclusionsBased on very low certainty of the evidence, patients with Down syndrome had a higher prevalence and likelihood and severity of tooth wear when compared to those without Down syndrome.Clinical relevanceScreening early tooth wear lesions should be carefully done in the Down syndrome population since its occurrence is remarkable compared to the general population.
Source: Clinical Oral Investigations - January 11, 2023 Category: Dentistry Source Type: research
IJERPH, Vol. 20, Pages 2769: Influence of Foot Morphology on the Center of Pressure Pattern in Patients with Down Syndrome
Conclusions: These results suggest that the sensory deficits and the development of hypotonic muscles and lax ligaments of the syndrome lead to morphological alterations of the foot that, combined with the physical characteristics of short stature and obesity, negatively impact the CoP pattern of people with Down syndrome during walking.
Source: International Journal of Environmental Research and Public Health - February 4, 2023 Category: Environmental Health Authors: Cristina Ferrario Claudia Condoluci Marco Tarabini Carlotta Maria Manzia Gabriella Di Girolamo Massimiliano Pau Manuela Galli Tags: Article Source Type: research
Quality of life in adults with Down syndrome: A mixed methods systematic review
ConclusionThis review highlighted the need for a better systematic approach to improving the quality of life in adults with Down syndrome in targeted areas. Future research is required to evaluate self-and proxy-reporting methods and culture-specific quality of life instruments that are more appropriate for adults with Down syndrome. In addition, further studies should consider including digital assistive technologies to obtain self-reported quality of life data in adults with Down syndrome. International prospective register of systematic reviews registration numberCRD42019140056.
Source: PLoS One - May 1, 2023 Category: Biomedical Science Authors: Ogochukwu Ann Ijezie Source Type: research
Contributions of a specialty clinic for children and adolescents with Down syndrome
Abstract
We investigated what added value, if any, a Down syndrome specialty clinic brings to the healthcare needs of children and adolescents with Down syndrome. For this quality improvement study, we performed a retrospective chart review of 105 new patients with Down syndrome, ages 3 and older, seen during the inaugural year of our specialty clinic. We asked how many of our patients were already up‐to‐date on the healthcare screenings recommended for people with Down syndrome. We further analyzed what tests we ordered, which referrals we suggested, and, ultimately, what new diagnoses of co‐occurring medical condit...
Source: American Journal of Medical Genetics Part A - February 7, 2013 Category: Genetics & Stem Cells Authors: Brian G. Skotko, Emily Jean Davidson, Gil S. Weintraub Tags: Research Article Source Type: research
Outlawing Abortion Will Help Children with Down Syndrome
On the New York Times parenting blogs, a mother of a girl with Down Syndrome argues against North Dakota's new law that outlaws abortion in cases of genetic abnormality. Alison Piepmeier says that Outlawing Abortion Wont Help Children with Down Syndrome. The premise is that parents abort babies with Down Syndrome because their child will face untold challenges. Piepmeier writes about her conversations with women who aborted their children:Repeatedly women told me that they ended the pregnancy not because they wanted a perfect child (as one woman said, I dont know what perfect child even means) but...
Source: Mary Meets Dolly - April 4, 2013 Category: Geneticists and Genetics Commentators Tags: Abortion Source Type: blogs
Self-advocate helps all
By Olivia Lepore
Nate at work
Learning that your child has been diagnosed with Down syndrome can be a challenging experience for many parents. At Boston Children’s Hospital, the Down Syndrome Program has found a way to give hope to both parents and children who come to the clinic—his name is Nate Simons. Simons is a valued 24-year-old member of the program’s staff, and like the children he interacts with at the clinic, he has Down syndrome.
Simons—who joined the team last fall—is the program’s second self-advocate, a two-year position funded by a generous gift to the hospital from a patient family. He was ...
Source: Thrive, Children's Hospital Boston - April 30, 2013 Category: Pediatrics Authors: Guest Blogger Tags: All posts Down syndrome GQ mocks people with Down Syndrome what are the job opportunities for people with down syndrome? working with Down syndrome? Source Type: news
Surgical outcome of congenital heart disease in Down's syndrome
Conclusion: children with Down’s syndrome can be operated on with negligible mortality and good functional outcome, but with a higher surgical morbidity.
Source: Asian Cardiovascular and Thoracic Annals - April 1, 2013 Category: Cardiology Authors: Lal, P. S., Chavan, B., Devendran, V. R., Varghese, R., Murmu, U. C., Kumar, R. S. Tags: Cardiovascular Source Type: research
Evidence that PICALM affects age at onset of Alzheimer's dementia in Down syndrome.
Abstract
It is known that individuals with Down syndrome develop Alzheimer's disease with an early age at onset, although associated genetic risk factors have not been widely studied. We tested whether genes that increase the risk of late-onset Alzheimer's disease influence the age at onset in Down syndrome using genome-wide association data for age at onset of dementia in a small sample of individuals (N = 67) with Down syndrome. We tested for association with loci previously associated with Alzheimer's disease risk and, despite the small size of the study, we detected associations with age at onset of Alzheimer...
Source: Neurobiology of Aging - April 17, 2013 Category: Geriatrics Authors: Jones EL, Mok K, Hanney M, Harold D, Sims R, Williams J, Ballard C Tags: Neurobiol Aging Source Type: research
Memory coding in individuals with Down syndrome.
Abstract
Previous research has identified a deficit in phonological short-term memory in individuals with Down syndrome. The present work aimed to analyze how a group of 30 individuals with Down syndrome performed in a picture span task compared with 30 typically developing children of the same mental age. The task involved four conditions (i.e., dissimilar, phonologically similar, visually similar, and long-name items) chosen to analyze the strategy used by individuals with Down syndrome to code visually presented nameable items. Individuals with Down syndrome performed less well than typically developing childre...
Source: Child Neuropsychology - November 15, 2013 Category: Child Development Authors: Lanfranchi S, Toffanin E, Zilli S, Panzeri B, Vianello R Tags: Child Neuropsychol Source Type: research
"I have a good life": the meaning of well-being from the perspective of young adults with Down syndrome.
Conclusion: Overall, the findings from this study revealed that the participants' life perspective was positive, with a general consensus of, "I have a good life". This study yielded many recommendations that could be integrated into transition models of service delivery for young adults with Down syndrome as they develop from adolescence into adulthood. Implications of Rehabilitation Young people with Down syndrome want to make decisions for themselves. Community participation is important for young adults with Down syndrome. Young people with Down syndrome have dreams and aspirations for their future, and should be fully...
Source: Disability and Rehabilitation - November 28, 2013 Category: Rehabilitation Authors: Scott M, Foley KR, Bourke J, Leonard H, Girdler S Tags: Disabil Rehabil Source Type: research
Maternal obesity and risk of Down syndrome in the offspring
ConclusionMaternal obesity seems to increase the risk for Down syndrome births. The risk estimate for Down syndrome with 1st trimester combined screening is unaffected by BMI. This article is protected by copyright. All rights reserved.
Source: Prenatal Diagnosis - December 1, 2013 Category: Perinatology & Neonatology Authors: Eric Hildebrand, Bengt Källén, Ann Josefsson, Tomas Gottvall, Marie Blomberg Tags: Original Article Source Type: research
Communication and self-esteem in adults with Down syndrome.
CONCLUSIONS & IMPLICATION: This study demonstrated that people with Down syndrome may experience low self-esteem that may be linked to communication. The clinical implications of this are considered and areas for future research are identified.
PMID: 24617604 [PubMed - as supplied by publisher]
Source: International Journal of Language and Communication Disorders - March 12, 2014 Category: Speech Therapy Authors: Jackson C, Cavenagh P, Clibbens J Tags: Int J Lang Commun Disord Source Type: research
Combined folate gene MTHFD and TC polymorphisms as maternal risk factors for Down syndrome in China.
In conclusion, neither MTHFD G1958A nor TC C776G polymorphisms are an independent risk factor for Down syndrome. However, the combined MTHFD/MTHFR, TC/MTHFR genotypes play a role in the risk of bearing a Down syndrome child in the Chinese population.
PMID: 24668664 [PubMed - in process]
Source: Genetics and Molecular Research - March 30, 2014 Category: Genetics & Stem Cells Authors: Liao YP, Zhang D, Zhou W, Meng FM, Bao MS, Xiang P, Liu CQ Tags: Genet Mol Res Source Type: research
Relationship dimensions of the ‘Down syndrome advantage’
ConclusionsChildren with Down syndrome and their mothers have more positive interactions than children with other developmental disabilities, both in terms of the responsiveness of mothers and of child responses contingent on maternal behaviour. These findings suggest that both children with Down syndrome themselves and their mothers are contributing to a Down syndrome advantage.
Source: Journal of Intellectual Disability Research - July 29, 2014 Category: Disability Authors: D. B. Mitchell, P. Hauser‐Cram, M. K. Crossman Tags: Original Article Source Type: research
Hospitalizations and associated costs in a population‐based study of children with down syndrome born in Florida
ConclusionResults support findings that for children with Down syndrome the presence of other anomalies influences hospital use and costs, and children with severe CHDs have greater hospital resource usage than children with other CHDs or major birth defects without CHDs. Birth Defects Research (Part A), 2014. © 2014 Wiley Periodicals, Inc.
Source: Birth Defects Research Part A: Clinical and Molecular Teratology - August 13, 2014 Category: Perinatology & Neonatology Authors: April L. Dawson, Cynthia H. Cassell, Matthew E. Oster, Richard S. Olney, Jean Paul Tanner, Russell S. Kirby, Jane Correia, Scott D. Grosse Tags: Original Research Article Source Type: research
