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Association of biological sex with clinical outcomes and biomarkers of Alzheimer's disease in adults with Down syndrome
Brain Commun. 2023 Mar 17;5(2):fcad074. doi: 10.1093/braincomms/fcad074. eCollection 2023.ABSTRACTThe study of sex differences in Alzheimer's disease is increasingly recognized as a key priority in research and clinical development. People with Down syndrome represent the largest population with a genetic link to Alzheimer's disease (>90% in the 7th decade). Yet, sex differences in Alzheimer's disease manifestations have not been fully investigated in these individuals, who are key candidates for preventive clinical trials. In this double-centre, cross-sectional study of 628 adults with Down syndrome [46% female, 44.4 (...
Source: Clin Med Res - April 14, 2023 Category: Research Authors: M Florencia Iulita Alexandre Bejanin Eduard Vilaplana Maria Carmona-Iragui Bessy Benejam Laura Videla Isabel Barroeta Susana Fern ández Miren Altuna Jordi Pegueroles Victor Montal Silvia Valldeneu Sandra Gim énez Sof ía González-Ortiz Soraya Torres Sh Source Type: research

The Relationship Between Hypothyroidism and Cardiac Findings in Children With and Without Down Syndrome
CONCLUSION: Cardiac morphology and functions were signi���cantly a���ected by hypothyroidism in patients with Down syndrome. Hypertrophy in Down syndrome may be caused by the cellular changes in myocardium.PMID:36999332 | DOI:10.5543/tkda.2023.70337
Source: Turk Kardiyoloji Dernegi arsivi - March 31, 2023 Category: Cardiology Authors: B Ra S Zen Celbek Haz M Alper G Rsu Emine Azak Eda Mengen P Nar Kocaay Brahim Lker Etin Source Type: research