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Total 5148657 results found since Jan 2013.
Pharmacological inhibition of S6K1 rescues synaptic deficits and attenuates seizures and depression in chronic epileptic rats
CONCLUSION: In conclusion, our data suggest that inhibition of S6K1 attenuates seizures and depression in chronic epileptic rats via the rescue of synaptic structural and functional deficits. Given the wide range of physiological functions of mTOR, inhibition of its effective but relatively simple functional downstream molecules is a promising target for the development of drugs for epilepsy.PMID:37736829 | DOI:10.1111/cns.14475
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Yuying Zhang Xiaojuan Cheng Luyan Wu Juan Li Changyun Liu Mingjia Wei Chaofeng Zhu Huapin Huang Wanhui Lin Source Type: research
The prevalence and risk factors study of cognitive impairment: Analysis of the elderly population of Han nationality in Hunan province, China
CONCLUSION: A representative prevalence of cognitive impairment, MCI, and dementia was found in the elderly Han Chinese population in Southern China. And we further explored the role of known risk factors, particularly in physical activity, smoking, and alcohol consumption.PMID:37736696 | DOI:10.1111/cns.14478
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Tianyan Xu Guiwen Bu Li Yuan Lu Zhou Qijie Yang Yuan Zhu Sizhe Zhang Qianqian Liu Ziyu Ouyang Xuan Yang Beisha Tang Bin Jiao Yuzhang Bei Lu Shen Source Type: research
Melatonin regulates the circadian rhythm to ameliorate postoperative sleep disorder and neurobehavioral abnormalities in aged mice
CONCLUSIONS: Melatonin receptors in SCN, circadian rhythm, and ERK/CREB signaling pathway participate in the pathophysiological processes of PSD and delirium-like behavior. Melatonin intervention could be a potential preventative approach for PSD and delirium.PMID:37736695 | DOI:10.1111/cns.14436
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Xixi Jia Yanan Song Zhengqian Li Ning Yang Taotao Liu Dengyang Han Zhuonan Sun Chengmei Shi Yang Zhou Jie Shi Yajie Liu Xiangyang Guo Source Type: research
NcRNAs: A synergistically antiapoptosis therapeutic tool in Alzheimer's disease
CONCLUSIONS: This review provides a future diagnosis and treatment strategy for AD patients based on ncRNAs.PMID:37735992 | DOI:10.1111/cns.14476
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Liangxian Li Mingyue Jin Jie Tan Bo Xiao Source Type: research
Rasd1 is involved in white matter injury through neuron-oligodendrocyte communication after subarachnoid hemorrhage
CONCLUSIONS: It can be concluded that Rasd1 exerts a modulated role in oligodendrocytes ferroptosis in WMI following SAH.PMID:37735980 | DOI:10.1111/cns.14452
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Wenqiao Fu Xudong Che Jiahe Tan Shizhen Cui Yinrui Ma Daiqi Xu Haibo Long Xiaolin Yang Tangmin Wen Zhaohui He Source Type: research
NRF1 mitigates motor dysfunction and dopamine neuron degeneration in mice with Parkinson's disease by promoting GLRX m < sup > 6 < /sup > A methylation through upregulation of METTL3 transcription
CONCLUSION: Conclusively, NRF1 constrained motor dysfunction and dopamine neuron degeneration in MPTP-induced PD mice by activating the METTL3/GLRX axis.PMID:37735974 | DOI:10.1111/cns.14441
Source: CNS Neuroscience and Therapeutics - September 22, 2023 Category: Neuroscience Authors: Xin Gong Mengyi Huang Lei Chen Source Type: research
Candidate Key Proteins in Tinnitus: A Bioinformatic Study of Synaptic Transmission in Spiral Ganglion Neurons
Cell Mol Neurobiol. 2023 Sep 22. doi: 10.1007/s10571-023-01405-w. Online ahead of print.ABSTRACTTo study key proteins associated with changes in synaptic transmission in the spiral ganglion in tinnitus, we build three gene lists from the GeneCard database: 1. Perception of sound (PoS), 2. Acoustic stimulation (AcouStim), and 3. Tinnitus (Tin). Enrichment analysis by the DAVID database resulted in similar Gene Ontology (GO) terms for cellular components in all gene lists, reflecting synaptic structures known to be involved in auditory processing. The STRING protein-protein interaction (PPI) network and the Cytoscape data an...
Source: Cellular and Molecular Neurobiology - September 22, 2023 Category: Cytology Authors: Johann Gross Marlies Knipper Birgit Mazurek Source Type: research
EGR1 Promotes Ovarian Hyperstimulation Syndrome Through Upregulation of SOX9 Expression
This study aimed to investigate the function and mechanism of EGR1 involved in OHSS progression. RNA-sequencing was used to identify differentially expressed genes. In vitro OHSS cell model was induced by treating KGN cells with human chorionic gonadotropin (hCG). In vivo OHSS model was established in mice. The expression levels of EGR1, SOX1, and VEGF were determined by Quantitative Real-Time polymerase chain reaction (qRT-PCR), Western blot, immunofluorescence staining, and immunochemistry assay. The content of VEGF in the culture medium of human granulosa-like tumor cell line (KGN) cells was accessed by the ELISA assay....
Source: Cell Transplantation - September 22, 2023 Category: Cytology Authors: Huihui Wang Weijia Chen Yinan Huang Yuan Sun Yuanhua Liu Yuanchao Zhu Zongxuan Lu Source Type: research
Muscle synergies are associated with intermuscular coherence and cortico-synergy coherence in an isometric upper limb task
Exp Brain Res. 2023 Sep 22. doi: 10.1007/s00221-023-06706-6. Online ahead of print.ABSTRACTTo elucidate the underlying physiological mechanisms of muscle synergies, we investigated long-range functional connectivity by cortico-muscular (CMC), intermuscular (IMC) and cortico-synergy (CSC) coherence. Fourteen healthy participants executed an isometric upper limb task in synergy-tuned directions. Cortical activity was recorded using 32-channel electroencephalography (EEG) and muscle activity using 16-channel electromyography (EMG). Using non-negative matrix factorisation (NMF), we calculated muscle synergies from two differen...
Source: Experimental Brain Research - September 22, 2023 Category: Neuroscience Authors: Pablo Ortega-Auriol Winston D Byblow Thor Besier Angus J C McMorland Source Type: research
Sleep Spindle Generation Before and After Epilepsy Surgery: A Source Imaging Study in Children with Drug-Resistant Epilepsy
CONCLUSIONS: Our data indicate alterations in the EEG slow spindles after resective epilepsy surgery. Fast spindle generation on the contrary did not change after surgery. Although the study is limited by its retrospective nature, lack of healthy controls, and reduced cortical spatial sampling, our findings suggest a spatial relationship between the slow spindles and the epileptogenic generators.PMID:37737957 | DOI:10.1007/s10548-023-01007-1
Source: Brain Topography - September 22, 2023 Category: Neuroscience Authors: Assia Chericoni Lorenzo Ricci Georgios Ntolkeras Roberto Billardello Scellig S D Stone Joseph R Madsen Christos Papadelis P Ellen Grant Phillip L Pearl Fabrizio Taffoni Alexander Rotenberg Eleonora Tamilia Source Type: research
Single-cell and bulk sequencing analyses reveal the immune suppressive role of PTPN6 in glioblastoma
Aging (Albany NY). 2023 Sep 21;15. doi: 10.18632/aging.205052. Online ahead of print.ABSTRACTGlioblastoma (GBM) is a highly malignant brain cancer with a poor prognosis despite standard treatments. This investigation aimed to explore the feasibility of PTPN6 to combat GBM with immunotherapy. Our study employed a comprehensive analysis of publicly available datasets and functional experiments to assess PTPN6 gene expression, prognostic value, and related immune characteristics in glioma. We evaluated the influence of PTPN6 expression on CD8+ T cell exhaustion, immune suppression, and tumor growth in human GBM samples and mo...
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Xiaonan Zhang Jie Chen Ming Zhang Saisai Liu Tao Wang Tianyu Wu Baiqing Li Shidi Zhao Hongtao Wang Li Li Chun Wang Li Huang Source Type: research
The oncogenic miR-429 promotes triple-negative breast cancer progression by degrading DLC1
In conclusion, our findings reveal the mechanism of tumorigenic miR-429 in TNBC, which paves the way for target therapies translation in clinical settings.PMID:37737712 | DOI:10.18632/aging.205051
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Yao Li Xue Meng Yuqing Luo Shuai Luo Jin Li Jiafei Zeng Xiang Huang Jinjing Wang Source Type: research
Prognosis and immunoinfiltration analysis of angiogene-related genes in grade 4 diffuse gliomas
Aging (Albany NY). 2023 Sep 21;15. doi: 10.18632/aging.205054. Online ahead of print.ABSTRACTAlthough angiogenesis critically influences the progression of solid tumors, its contribution to highly malignant, grade 4 diffuse gliomas remains unclear. After analyzing 506 angiogenesis-related genes differentially expressed in grade 4 diffuse gliomas via LASSO and univariate and multivariate COX regression analyses, we constructed a nomogram based on COL22A1, IGFBP2, and MPO that accurately predicted patient survival. The nomogram's performance was validated in an external patient cohort, and a risk score based on the formula C...
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Hui Liu Zhirui Zeng Peng Sun Source Type: research
A novel risk model of three gefitinib-related genes FBP1, SBK1 and AURKA is related to the immune microenvironment and is predicting prognosis of lung adenocarcinoma patients
CONCLUSION: FBP1, SBK1, and AURKA are prognostic risk factors, and the risk model and nomogram of FBP1, SBK1 and AURKA are associated with dismal prognosis and immune cell infiltration, and have huge prospects for application in evaluating the prognosis in LUAD.PMID:37737707 | DOI:10.18632/aging.205040
Source: Aging - September 22, 2023 Category: Biomedical Science Authors: Qiang Guo Kai Li Ni Jiang Rui Zhou Xin-Rui Rao Chuang-Yan Wu Source Type: research
Correlations Among Maternal and Infant Factors, Lead Exposure, and Serum Prolactin Levels During Lactation: A Cross-sectional Study
CONCLUSIONS: Breastfeeding frequency had a stronger positive relationship with serum prolactin levels than protein and calcium intake. However, lead exposure was associated with reduced serum prolactin levels during lactation. Consequently, specific interventions from policymakers are necessary to manage breastfeeding in mothers exposed to lead.PMID:37735831 | DOI:10.3961/jpmph.23.238
Source: Journal of Preventive Medicine and Public Health - September 22, 2023 Category: International Medicine & Public Health Authors: Linda Ratna Wati Djanggan Sargowo Tatit Nurseta Lilik Zuhriyah Bambang Rahardjo Source Type: research
