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Impairment measures versus inflammatory RODS in GBS and CIDP: a responsiveness comparison
This study aimed to ‘define responder’ through the concept of minimum clinically important differences using the individually obtained standard errors (MCID‐SE) and a heuristic ‘external criterion’ responsiveness method in patients with Guillain‐Barré syndrome (GBS) and chronic inflammatory demyelinating polyradiculoneuropathy (CIDP). One hundred and fourteen newly diagnosed or relapsing patients (GBS: 55, CIDP: 59) were serially examined (1‐year follow‐up). The inflammatory Rasch‐built overall disability scale (I‐RODS), Rasch‐transformed MRC sum score (RT‐MRC), and Rasch‐transformed modified‐I...
Source: Journal of the Peripheral Nervous System - September 28, 2015 Category: Neurology Authors: Els K. Vanhoutte, Thomas H. P. Draak, Kenneth C. Gorson, Sonja I. van Nes, Janneke G. J. Hoeijmakers, W.‐Ludo Van der Pol, Nicolette. C. Notermans, Richard A. Lewis, Eduardo Nobile‐Orazio, Jean‐Marc Léger, Peter Y. K. Van den Bergh, Giuseppe Lauria Tags: RESEARCH REPORT Source Type: research

Motor unit number index (MUNIX): Is it relevant in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)?
CONCLUSIONS: The MUNIX technique has a good reproducibility and the MUNIX sumscore is related to the disability. SIGNIFICANCE: The MUNIX technique estimates the axonal loss and the number of functional motor units. The MUNIX sumscore may be a good instrument to evaluate the CIDP patients during their follow-up. PMID: 26750580 [PubMed - as supplied by publisher]
Source: Clinical Neurophysiology - December 12, 2015 Category: Neurology Authors: Delmont E, Benvenutto A, Grimaldi S, Duprat L, Philibert M, Pouget J, Grapperon AM, Salort-Campana E, Sévy A, Verschueren A, Attarian S Tags: Clin Neurophysiol Source Type: research

Intravenous Immunoglobulin (IVIg) Treatment-Related Fluctuations in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Patients Using Daily Grip Strength Measurements (GRIPPER): Study Design and Progress Update (P2.269)
Conclusion: The GRIPPER study may provide clinically relevant outcomes data for CIDP patients receiving IVIg and explore the relationship between IVIg dosing, interval, and treatment-related fluctuations in routine clinical practice. Patient recorded GS is feasible and practical. Serum IgG levels and clinical response to IVIg may develop better evidence based dosing strategies.Disclosure: Dr. Allen has nothing to disclose. Dr. Pasnoor has nothing to disclose. Dr. Burns has received personal compensation in an editorial capacity for Neurology. Dr. Ajroud-Driss has nothing to disclose. Dr. Ney has received personal compensat...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Allen, J., Pasnoor, M., Burns, T., Ajroud-Driss, S., Ney, J., Cook, A., Kissel, J., Gorson, K., Lewis, R., Berger, M., Riley, P., Schaefer, D., Timothy, W. Tags: Treatments of Peripheral Neuropathies and Cramps Source Type: research

Magnetic resonance neurography for the evaluation of CIDP
This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - August 7, 2016 Category: Internal Medicine Authors: Tomomasa Ishikawa, Kunihiko Asakura, Yasuaki Mizutani, Akihiro Ueda, Ken ‐ichiro Murate, Chika Hikichi, Sayuri Shima, Madoka Kizawa, Masako Komori, Kazuhiro Murayama, Hiroshi Toyama, Shinji Ito, Tatsuro Mutoh Tags: Research Article Source Type: research

Electrophysiological and neuromuscular stability of persons with chronic inflammatory demyelinating polyneuropathy (CIDP)
CONCLUSION: CIDP had lower strength and CMAP values, moderately fewer numbers of MUs, and significant neuromuscular instability compared with controls. Thus, in addition to muscle atrophy, voluntary weakness is also due to limitations of peripheral neural transmission consistent with demyelination. This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - December 19, 2016 Category: Internal Medicine Authors: Kevin J. Gilmore, Matti D. Allen, Timothy J. Doherty, Kurt Kimpinski, Charles L. Rice Tags: Research Article Source Type: research

MR neurography for the evaluation of CIDP
Conclusions: MR neurography and the measurement of peripheral nerve volume are useful for diagnosing and assessing CIDP. Muscle Nerve, 2016
Source: Muscle and Nerve - December 25, 2016 Category: Internal Medicine Authors: Tomomasa Ishikawa, Kunihiko Asakura, Yasuaki Mizutani, Akihiro Ueda, Ken ‐Ichiro Murate, Chika Hikichi, Sayuri Shima, Madoka Kizawa, Masako Komori, Kazuhiro Murayama, Hiroshi Toyama, Shinji Ito, Tatsuro Mutoh Tags: Research Article Source Type: research

Intravenous Immunoglobulin (IVIg) Treatment-Related Fluctuations in Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) Patients Using Daily Grip Strength Measurements (GRIPPER): Study design and progress update (P5.126)
Conclusion:The GRIPPER study may provide clinically relevant outcomes data for CIDP patients receiving IVIg and explore the relationship between IVIg dosing, interval, and treatment-related fluctuations in routine clinical practice. Patient recorded GS is feasible and practical. Serum IgG levels and clinical response to IVIg may develop better evidence based dosing strategies.Study Supported by:Supported by CSL Behring - investigator-initiated study grant.Disclosure: Dr. Allen has nothing to disclose. Dr. Pasnoor has nothing to disclose. Dr. Burns has received personal compensation in an editorial capacity for the Neurolog...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Allen, J., Pasnoor, M., Burns, T., Ajroud-Driss, S., Cook, A., Brannagan, T., Lawson, V., Ney, J., Kissel, J., Gorson, K., Lewis, R., Walton, T. Tags: Neuromuscular and Clinial Neurophysiology (EMG): Peripheral Neuropathy II Source Type: research

Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP): MRI
Discussionby Dr MGK Murthy, Dr GA PrasadChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is characterized clinically by a progressive or relapsing course of many months to years of symptoms similar to compressive myelopathy.Etiology Remains unknown, but T-cell activation in nerves plays an important role in the pathogenesis of CIDP& antigens in Schwann cells have been identified.PathologicallyCIDP is characterized by mononuclear cell infiltrates, edema, segmental demyelination, and remyelination&“onion bulb formation” which describes enlarged fascicles with increased endoneural connective t...
Source: Sumer's Radiology Site - December 12, 2017 Category: Radiology Authors: Sumer Sethi Source Type: blogs

Peripheral neuropathies: Subcutaneous immunoglobulin — the future of CIDP treatment?
Peripheral neuropathies: Subcutaneous immunoglobulin — the future of CIDP treatment?, Published online: 12 January 2018; doi:10.1038/nrneurol.2017.179Results from the PATH study indicate that subcutaneous immunoglobulin is efficacious and well tolerated for maintenance treatment in chronic inflammatory demyelinating polyneuropathy (CIDP). This finding represents an important step in the management of patients with immunoglobulin-responsive CIDP, with considerable implications for the cost of treatment and, most importantly, for these patients' quality of life.
Source: Nature Reviews Neurology - January 12, 2018 Category: Neurology Authors: Benjamin R. Wakerley Nobuhiro Yuki Source Type: research

Six-minute walk test is reliable and sensitive in detecting response to therapy in CIDP
ConclusionsThe combination of the 6MWT with the other clinical measures increased the chance to detect the quote of responders. We propose to include the 6MWT in the routine assessment of CIDP patients and the MCID cutoff at 20 m could be set for identifying the responders and properly guiding the therapy management.
Source: Journal of Neurology - February 5, 2019 Category: Neurology Source Type: research

Tonic pupils: an unusual autonomic involvement in chronic inflammatory demyelinating polyneuropathy (CIDP)
ConclusionsTonic pupils have previously been described in different neurologic conditions, including GBS, but not yet in acute onset CIDP or in variants with predominantly distal demyelination. It differs from the classical Adie ’s pupil because it lacks the light-near dissociation. This case report expands the range of possible autonomic signs in acute onset CIDP, which could help physicians establish optimal treatment strategies earlier on.
Source: Neurological Sciences - April 16, 2019 Category: Neurology Source Type: research

Long-term safety and efficacy of subcutaneous immunoglobulin IgPro20 in CIDP: PATH extension study
Conclusions Subcutaneous treatment with IgPro20 provided long-term benefit at both 0.4 and 0.2 g/kg weekly doses with lower relapse rates on the higher dose. Long-term dosing should be individualized to find the most appropriate dose in a given patient. Classification of evidence This study provides Class IV evidence that for patients with CIDP, long-term treatment with SCIG beyond 24 weeks is safe and efficacious.
Source: Neurology Neuroimmunology and Neuroinflammation - July 2, 2019 Category: Neurology Authors: van Schaik, I. N., Mielke, O., Bril, V., van Geloven, N., Hartung, H.-P., Lewis, R. A., Sobue, G., Lawo, J.-P., Praus, M., Durn, B. L., Cornblath, D. R., Merkies, I. S. J., on behalf of the PATH study group Tags: Chronic inflammatory demyelinating polyneuropathy, Clinical trials Observational study (Cohort, Case control), Class IV Article Source Type: research

Human leukocyte antigens class II in CIDP spectrum neuropathies
CIDP spectrum encompasses several clinical variants and the reasons of the heterogeneous clinical expression and the variable response to therapy are scarcely known.HLA associations are common in dysimmune conditions. In CIDP, few studies reported no associations or HLA-DR13/DQ6 association in some populations but, to date, a clear confirmed association is lacking.We analyzed expression of HLA-DR and DQ haplotypes in 24 CIDP patients and 216 healthy subject.HLA-DR3 and DR3/DQ2 were significantly more frequent in CIDP patients than in the control group.
Source: Journal of the Neurological Sciences - October 22, 2019 Category: Neurology Authors: Stefano Cotti Piccinelli, Graziella Carella, Micol Frassi, Filomena Caria, Serena Gallo Cassarino, Enrico Baldelli, Mirella Marini, Angela Tincani, Alessandro Padovani, Massimiliano Filosto Source Type: research

Abnormality of multimodal evoked potentials in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
ConclusionsThe authors indicated to the possibility of central sensory involvement in patients with CIDP, especially based on the prolonged inter-latency of BAEPs with simultaneously confirmed root affection. The severity of central damage correlates with the degree of peripheral nerve impairment.
Source: Neurological Sciences - March 23, 2020 Category: Neurology Source Type: research

Treatment of CIDP patients with antibodies against paranodal proteins
AbstractChronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired immune ‐mediated polyneuropathy characterized by relapsing or steadily progressive clinical course. A major feature of the syndrome is that it encompasses several pathogeneses, and it is actually assumed that both cellular and humoral immunity can be involved with superiority depending on the particular subtype. While cellular immunity typified by macrophage‐derived demyelination can play an essential role in classical CIDP, other pathogeneses that involve humoral immunity, such as autoantibodies targeting Node of Ranvier proteins (...
Source: Clinical and Experimental Neuroimmunology - April 16, 2020 Category: Neurology Authors: Masahiro Iijima Tags: REVIEW ARTICLE (INVITED) Source Type: research