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Challenges in the diagnosis of chronic inflammatory demyelinating polyneuropathy
ConclusionsAdherence to EFNS/PNS CIDP diagnostic and treatment guidelines in the general neurologic community was poor. Improved education and awareness of widely available CIDP guidelines are recommended. Diagnosing chronic inflammatory demyelinating polyneuropathy (CIDP) can be challenging. We observed that within the general community adherence to European Federation of Neurological Societies/Peripheral Nerve Society (EFNS/PNS) CIDP diagnostic and treatment guidelines was poor. Improved education and awareness of widely available CIDP guidelines are recommended.
Source: Brain and Behavior - January 1, 2018 Category: Neurology Authors: Jeffrey A. Allen, Kenneth C. Gorson, Deborah Gelinas Tags: ORIGINAL RESEARCH Source Type: research

Diagnostic usefulness of plexus MRI in chronic inflammatory demyelinating polyradiculopathy without electrodiagnostic criteria of demyelination
ConclusionsOur observations suggest that plexus MRI makes a valuable contribution to the diagnosis of CIDP ‐ND patients. Further studies are needed to investigate inter‐rater reliability of clinical and imaging criteria of CIDP in these patients, and the impact on outcomes.This article is protected by copyright. All rights reserved.
Source: European Journal of Neurology - November 15, 2018 Category: Neurology Authors: Guillaume Fargeot, Karine Viala, Marie Theaudin, Marc ‐Antoine Labeyrie, Raquel Costa, Jean Marc Léger, David Adams, Christophe Vandendries, Celine Labeyrie Tags: Original Article Source Type: research

CIDP associated with Sj ögren’s syndrome
ConclusionsIn conclusion, our data indicate that cranial nerve impairment and female gender might represent red flags for an additional Sj ögren’s syndrome in patients with CIDP. The patterns of clinical disabilities and electrophysiological findings due to peripheral nerve damage are similar in both CIDP entities.
Source: Journal of Neurology - February 21, 2021 Category: Neurology Source Type: research

Nerve Ultrasound Performances in Differentiating POEMS Syndrome from CIDP
In conclusion, compared with CIDP, nerve CSA enlargement was more homogeneous along the same nerve in individual POEMS patients, as well as among different POEMS patients. The addition of nerve ultrasound to nerve conduction studies significantly improves the differential d iagnosis between the two diseases.
Source: Neurotherapeutics - March 7, 2022 Category: Neurology Source Type: research

Different profiles of onion bulb in CIDP and CMT1A in relation to extracellular matrix.
Abstract Hypertrophic neuropathy is usually intractable, and chronic inflammatory demyelinating polyneuropathy (CIDP) and Charcot-Marie-Tooth disease Type 1A (CMT1A) are the representative disorders. The two disorders are sometimes confused both clinically and pathologically. The aim of this study was to clarify the differences in the pathology of large onion bulbs, focusing on the extracellular matrix (ECM) proteins. Nine patients with CIDP and 14 with CMT1A were included. The opened interspaces in OB were frequently shown in CMT1A patients. In CIDP, interspaces of OB packed with collagen fibers were prominent. T...
Source: Clinical Neuropathology - March 5, 2013 Category: Pathology Authors: Oka N, Kawasaki T, Unuma T, Shigematsu K, Sugiyama H Tags: Clin Neuropathol Source Type: research

Comparison of CIDP and MGUS Associated Neuropathy Patients (P4.120)
Conclusion:The results suggest that MGUSN patients have less severe neuropathy, are treated less frequently, and respond less to treatment than CIDP patients. MGUSN patients may do well without treatment and exposure to potential adverse effects.Disclosure: Dr. Alkhawajah has received personal compensation for activities with Biogen Idec. Dr. Dunnigan has nothing to disclose. Dr. Bril has received personal compensation for activities with CSL Ltd. Dr. Bril has received research support from CSL Ltd.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Alkhawajah, N., Dunnigan, S., Bril, V. Tags: Neuropathy: Pathogenesis and Diagnostic Testing Source Type: research

Chronic inflammatory demyelinating polyneuropathy (CIDP): change of serum IgG dimer levels during treatment with intravenous immunoglobulins
Conclusion: Assessment of IgG dimer levels could be a novel approach to monitor CIDP patients during IVIg treatment, but further studies in larger cohorts are warranted to explore their utility to serve as a potential therapeutic biomarker for IVIg treatment response in CIDP.
Source: Journal of Neuroinflammation - August 14, 2015 Category: Neurology Authors: Christian RitterIlja BobylevHelmar Lehmann Source Type: research

Evaluation of Patients with Refractory Chronic Inflammatory Demyelinating Polyneuropathy
Conclusions: Reasons for therapeutic failure in CIDP are inadequate immunotherapy and alternative diagnoses. Certain clinical and electrophysiological features help to distinguish true CIDP from mimics. Once CIDP is confirmed, optimization of IVIg dosing, addition of corticosteroids, plasmapheresis, or chemotherapy results in consistent improvement. Caution is advised when using response to therapy to diagnose CIDP. This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - July 26, 2016 Category: Internal Medicine Authors: Artem Kaplan, Thomas H. Brannagan Tags: Research Article Source Type: research

Blink R1 latency utility in diagnosis and treatment assessment of POEMS and CIDP
This article is protected by copyright. All rights reserved.
Source: Muscle and Nerve - June 24, 2017 Category: Internal Medicine Authors: Wei Wang, William J. Litchy, Michelle L. Mauermann, P. James B. Dyck, Angela Dispenzieri, Jay Mandrekar, Peter J. Dyck, Christopher J. Klein Tags: Basic Science Research Article Source Type: research

CIDP Antibodies Target Junction Proteins and Identify Patient Subgroups: An Autoantigenomic Approach
Conclusions The repertoire of targeted autoantigens of patients with CIDP differs in a systematic degree from those of controls. Systematic autoantigenomic approaches can help to understand the disease and to discover novel bioinformatical tools and novel autoantigen panels to improve diagnosis, treatment, prognosis, or patient stratification.
Source: Neurology Neuroimmunology and Neuroinflammation - January 6, 2021 Category: Neurology Authors: Moritz, C. P., Tholance, Y., Stoevesandt, O., Ferraud, K., Camdessanche, J.-P., Antoine, J.-C. Tags: All Immunology, Autoimmune diseases, Peripheral neuropathy, Chronic inflammatory demyelinating polyneuropathy Article Source Type: research

The Cost Effectiveness of Immunoglobulin vs. Hematopoietic Stem Cell Transplantation for CIDP
Background: Intravenous immunoglobulin (IVIG) is effective as standard first line therapy for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), but some patients remain dependent on its long-term use. Recently, we have reported that autologous non-myeloablative hematopoietic stem cell transplantation (HSCT) is an effective second line therapy for CIDP.Objectives: To compare the cost of chronic IVIG vs. autologous HSCT (a one-time therapy), we collected data on patients with CIDP undergoing HSCT between 2017 and 2019. This was compared with published literature on the costs and efficacy defined by the Inflam...
Source: Frontiers in Neurology - March 22, 2021 Category: Neurology Source Type: research

Pediatric CIDP: Diagnosis and Management. A Single-Center Experience
Conclusion: Childhood CIDP may occur in its typical form, but even ~50% of children can present as an atypical variant including distal, pure motor, or pure sensory. Most children have a good prognosis; however, many of them may require long-term treatment. This highlights the importance of an early diagnosis and treatment for childhood CIDP.
Source: Frontiers in Neurology - July 3, 2021 Category: Neurology Source Type: research

High-resolution ultrasound of peripheral nerves in late-onset hereditary transthyretin amyloidosis with polyneuropathy: similarities and differences with CIDP
ConclusionAlthough high-resolution ultrasonography of peripheral nerves provides reliable information in patients with ATTRv-PN, its usefulness as a standalone diagnostic tool to differentiate ATTRv-PN from CIDP might be limited.
Source: Neurological Sciences - November 21, 2021 Category: Neurology Source Type: research

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP): Current Therapies and Future Approaches
Curr Pharm Des. 2022 Mar 25. doi: 10.2174/1381612828666220325102840. Online ahead of print.ABSTRACTChronic inflammatory demyelinating polyneuropathy (CIDP) is an acquired immune-mediated polyradiculoneuropathy leading to disability via inflammatory demyelination of peripheral nerves. Various therapeutic approaches with different mechanisms of action are established for the treatment of CIDP. Of those, corticosteroids, intravenous or subcutaneous immunoglobulin, or plasma exchange are established first-line therapies as suggested by the recently revised EAN/PNS guidelines for the management of CIDP. In special cases, immuno...
Source: Current Pharmaceutical Design - March 27, 2022 Category: Drugs & Pharmacology Authors: Martin K R Sva čina Helmar C Lehmann Source Type: research