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The SEARCH for Diabetes in Youth Study: Rationale, Findings, and Future Directions.
Abstract The SEARCH for Diabetes in Youth (SEARCH) study was initiated in 2000, with funding from the Centers for Disease Control and Prevention and support from the National Institute of Diabetes and Digestive and Kidney Diseases, to address major knowledge gaps in the understanding of childhood diabetes. SEARCH is being conducted at five sites across the U.S. and represents the largest, most diverse study of diabetes among U.S. youth. An active registry of youth diagnosed with diabetes at age <20 years allows the assessment of prevalence (in 2001 and 2009), annual incidence (since 2002), and trends by age, ra...
Source: Diabetes Care - November 25, 2014 Category: Endocrinology Authors: Hamman RF, Bell RA, Dabelea D, D'Agostino RB, Dolan L, Imperatore G, Lawrence JM, Linder B, Marcovina SM, Mayer-Davis EJ, Pihoker C, Rodriguez BL, Saydah S, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research

Prevalence, Characteristics and Clinical Diagnosis of Maturity Onset Diabetes of the Young Due to Mutations in HNF1A, HNF4A, and Glucokinase: Results from the SEARCH for Diabetes in Youth.
Conclusions/Interpretation:In this systematic study of MODY in a large pediatric US diabetes cohort, unselected by referral pattern or family history, MODY was usually misdiagnosed and incorrectly treated with insulin. While many type 2 diabetes-like metabolic features were less common in the mutation-positive group, no single characteristic identified all patients with mutations. Clinicians should be alert to the possibility of MODY diagnosis, particularly in antibody negative youth with diabetes. PMID: 23771925 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - June 14, 2013 Category: Endocrinology Authors: Gilliam LK, Pihoker C, Ellard S, Hattersley AT, Dabelea D, Davis C, Dolan LM, Greenbaum CJ, Imperatore G, Lawrence JM, Marcovina SM, Mayer-Davis E, Rodriguez BL, Steck AK, Williams DE, for the SEARCH for Diabetes in Youth Study Group Tags: J Clin Endocrinol Metab Source Type: research

Dr. Google steps up its medical search game again
By better leveraging its Knowledge Graph smart search algorithm, Google is giving its health-related search functions a shot in the arm. Starting in the next few days, health searches on Google and via the Google app will display a wide range of medical facts about the disease or condition in question. “We’ll show you typical symptoms […]
Source: mobihealthnews - February 10, 2015 Category: Information Technology Authors: Jonah Comstock Tags: Uncategorized DIY health Google Google Knowledge Graph Google search health information search Mayo Clinic medical search online diagnosers video visits virtual visits Source Type: news

A novel fast Fourier transform accelerated off-grid exhaustive search method for cryo-electron microscopy fitting
This paper presents a novel fast Fourier transform (FFT)-based exhaustive search method extended to off-grid translational and rotational degrees of freedom. The method combines the advantages of the FFT-based exhaustive search, which samples all the conformations of a system under study on a grid, with a local optimization technique that guarantees to find the nearest optimal off-grid conformation. The method is demonstrated on a fitting problem and can be readily applied to a docking problem. The algorithm first samples a scoring function on a six-dimensional grid of size N6 using the FFT. This operation has an asymptoti...
Source: Journal of Applied Crystallography - June 26, 2017 Category: Physics Authors: Hoffmann, A. Perrier, V. Grudinin, S. Tags: cryo-EM fitting fast Fourier transform FFT exhaustive search off-grid search trust-region problem research papers Source Type: research

Announcing new links and annotations on Conserved Domain Search results!
Conserved Domain Search (CD Search) results now show domain architecture information and other annotations that further characterize predicted domain and protein function. These include links to PubMed, Gene Ontology (GO) terms, Enzyme Commission (EC) numbers, and the SPARCLE Domain Architecture Viewer. You can use these links on the results to find literature (PubMed), assign biological … Continue reading Announcing new links and annotations on Conserved Domain Search results! → The post Announcing new links and annotations on Conserved Domain Search results! appeared first on NCBI Insights.
Source: NCBI Insights - August 10, 2022 Category: Databases & Libraries Authors: NCBI Staff Tags: What's New Basic Local Alignment Search Tool (BLAST) Comparative Genomics Resource (CGR) Conserved Domains Database (CDD) Gene Ontology (GO) Subfamily Protein Architecture Labeling Engine (SPARCLE) Source Type: news

Facebook Graph Search in Medicine
Everyone has heard about the new Graph Search function on Facebook. It says “Want to start a book club or find a gym buddy? Connect with friends who like the same activities—and meet new people, too.” It will let Facebook users do searches by choosing different parameters (e.g. who goes to the same gym as me and is single). Well, many bloggers are optimistic about this launch and think it will be used in medicine too. I don’t think so and everyone should hope I’ll be right. It’s fun to identify friends in my community who I share the same multiple interests with (e.g. sci-fi and reading book...
Source: ScienceRoll - January 26, 2013 Category: Geneticists and Genetics Commentators Authors: Dr. Bertalan Meskó Tags: Facebook Health 2.0 Medical Search Medicine Medicine 2.0 Video Web 2.0 Source Type: blogs

FindZebra: A Search Engine That Diagnoses Rare Diseases
The Danish researchers behind FindZebra would not be happy about my title as they published a warning on the top of their search engine with the message: “This is a research project to be used only by medical professionals.” This search engine only uses medical databases similarly to SciencerollSearch and named the rare disease correctly after entering the symptoms 67%  of the time, compared to 32% using Google. I think educating both patients and medical professionals about the proper use of search engines and operators would provide even better results. Here is their description. There are close to 7,000 rar...
Source: ScienceRoll - April 5, 2013 Category: Geneticists and Genetics Commentators Authors: Dr. Bertalan Meskó Tags: eHealth Medical Search Medicine Medicine 2.0 Web 2.0 Source Type: blogs

Prevalence of Diabetes Mellitus in U.S. Youth in 2009: The SEARCH for Diabetes in Youth Study.
ConclusionDiabetes mellitus, one of the leading chronic diseases in childhood, affects over 190,000 (1 out of 433) youth less than age 20 years in the US, with racial and ethnic disparities seen in diabetes prevalence, overall and by diabetes type. PMID: 24041677 [PubMed - as supplied by publisher]
Source: Diabetes Care - September 16, 2013 Category: Endocrinology Authors: Pettitt DJ, Talton J, Dabelea D, Divers J, Imperatore G, Lawrence JM, Liese AD, Linder B, Mayer-Davis EJ, Pihoker C, Saydah SH, Standiford DA, Hamman RF, for the SEARCH for Diabetes in Youth Study Group Tags: Diabetes Care Source Type: research

Peripheral Neuropathy in Adolescents and Young Adults With Type 1 and Type 2 Diabetes From the SEARCH for Diabetes in Youth Follow-Up Cohort: A pilot study.
CONCLUSIONSDPN prevalence among youth with type 2 diabetes approached rates reported in adult populations with diabetes. Our findings suggest not only that youth with diabetes are at risk for DPN but also that many already show measurable signs of DPN. PMID: 24144652 [PubMed - as supplied by publisher]
Source: Diabetes Care - October 21, 2013 Category: Endocrinology Authors: Jaiswal M, Lauer A, Martin CL, Bell RA, Divers J, Dabelea D, Pettitt DJ, Saydah S, Pihoker C, Standiford DA, Rodriguez BL, Pop-Busui R, Feldman EL, for The SEARCH For Diabetes In Youth Study Group Tags: Diabetes Care Source Type: research

Sara—the Search and Rescue Dog—and her Game of Fetch
Editor’s note: Jana Sweeny is the American Red Cross’s Director of International Communications. She and her team are traveling around Colombia this week, visiting communities made safer by the Red Cross.   As we walk into the Colombian Red Cross training center in Pereira, a yellow lab comes bouncing up, waving her tail enthusiastically. The ball in her mouth turns out to be a lime and she is ready to play fetch. Because I can never say no to a dog, I begin a game of “fetch the lime” with her. It turns out that Sara isn’t just a fun companion–she is a retired search and rescue dog.  The Colo...
Source: Red Cross Chat - January 24, 2014 Category: Global & Universal Authors: Jenelle Eli Tags: International Preparedness colombia dogs pets Search and Rescue South America Source Type: news

Complementary, Alternative, and Other Noncomplete Decongestive Therapy Treatment Methods in the Management of Lymphedema: A Systematic Search and Review
Conclusions: No interventions were ranked as “recommended for practice” based on the Putting Evidence into Practice guidelines. Two treatment modalities in 3 studies were ranked as “likely to be effective” in reducing LE or in managing secondary LE complications. Consideration should be given that many of the PAMs demonstrate long-standing support within the literature, with broad parameters for therapeutic application and benefit for secondary conditions associated with LE. However, further investigation as to their individual contributory value and the factors that contribute to their efficacy, specific to LE, h...
Source: PM and R - September 20, 2013 Category: Rehabilitation Authors: Julia R. Rodrick, Ellen Poage, Ausanee Wanchai, Bob R. Stewart, Janice N. Cormier, Jane M. Armer Tags: Analytical Review: Systematic Search Source Type: research

The search for extraterrestrial intelligence - podcast
The most intensive ever search for alien lifeThis week it was revealed that astronomers are about to start the most intensive ever search for alien life. The Breakthrough Listen project will scan stars in 100 galaxies for radio and optical signatures that indicate someone, or something, is out there.Until now, the search for extraterrestrial intelligence - or SETI - has been met with an eerie silence. What makes scientists so convinced it's worthwhile looking for alien life? Continue reading...
Source: Guardian Unlimited Science - July 24, 2015 Category: Science Authors: Hannah Devlin Tags: Science Astronomy Seti (Search for Extraterrestrial Intelligence) Source Type: news

Factors influencing time to case registration for youth with type 1  and type 2 diabetes: SEARCH for Diabetes in Youth Study.
CONCLUSIONS: These findings highlight the need for continued childhood diabetes surveillance to identify future trends and influences on changes in prevalence and incidence. PMID: 27664849 [PubMed - as supplied by publisher]
Source: Annals of Epidemiology - August 31, 2016 Category: Epidemiology Authors: Crume TL, Hamman RF, Isom S, Talton J, Divers J, Mayer-Davis EJ, Zhong VW, Liese AD, Saydah S, Standiford DA, Lawrence JM, Pihoker C, Dabelea D, SEARCH for Diabetes in Youth Study Group Tags: Ann Epidemiol Source Type: research

Full-profile search – match by the Rietveld method
A new search – match procedure has been developed and tested which, in contrast to previously existing methods, does not use a set of lines identified from a diffraction pattern, but an optimized Rietveld fitting on the raw data. Modern computers with multicore processors allow the routine to be fast enough to perform the entire search in a reasonable time using quite large databases of crystal structures. The search – match is done using the crystal structures for all phases and the instrumental geometry, and as such can be applied to every kind of diffraction experiment, including X-rays, thermal/time-of-flight neutr...
Source: Journal of Applied Crystallography - May 13, 2019 Category: Physics Authors: Lutterotti, L. Pilli è re, H. Fontugne, C. Boullay, P. Chateigner, D. Tags: Rietveld method search – match diffraction full profile quantitative analysis research papers Source Type: research

Tasmania Fires Rage On as Police Search Burned Homes
By Morag MacKinnonPERTH, Australia (Reuters) - Australian police and defense forces searched burned-out vehicles and homes in the towns worst hit by wildfires on the island of Tasmania, where more than 40 fires still raged on Sunday.The blazes began on Thursday on the state's thinly populated southeastern coast, amid a fierce heatwave and strong winds.The heat eased over the weekend, slowing the fires, but late on Sunday firefighters issued an emergency warning for residents in Taranna, 47 km (29 miles) east of the state capital Hobart, where a fire burning for more than three days threatened residents.The national weather...
Source: Scientific American - Official RSS Feed - January 6, 2013 Category: Science Tags: Energy & Sustainability,Climate,Environment,Society Policy Source Type: research