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Easy as plums
I cut up a couple of punnets of plums. (I didn’t take the stones out, because life is short, and the people who will be eating them – ie mainly Alan and I – are quite capable of taking them out.) I broke a couple of cinnamon sticks over them. I added a sprinkle of ginger and drizzled some honey on top. I added a glug of orange extract, which is not strictly necessary, but does add a certain je ne sais quoi. I put the dish in the oven, at 180 degrees for half an hour, but that was really only because the oven was already on, cooking parkin, and the parkin had half an hour to go. The oven part is not an exa...
Source: Bah! to cancer - January 29, 2013 Category: Cancer Authors: Stephanie Tags: Life is Good baking plums Source Type: blogs

Up And Down The Ladder… Job Changes
Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us and we’ll share with it others. That’s right. Send us your announcements and we’ll find a home for them. Don’t be shy. Everyone wants to know who is coming and going, especially with all the layoffs. Despite the downsizing, there is movement. Here are some of the latest changes. Recognize anyone? And here is our regular feature. Send us a photo and we will spotlight a different person each week. This time around, we note that MyoKardia hired Jonathan Fox as chief medical officer. He previously was v...
Source: Pharmalot - February 1, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized BrainStorm Cell Therapeutics Clondalkin Comprehensive Clinical Development Cytovance Juventas Therapeutics Metrics MyoKardia Novella Clinical Novo Nordisk Pantheon Questcor Pharmaceuticals Synteract Source Type: blogs

The Antidepressant Era: the movie
No apologies here, this article (and videos) have been lifted straight from David Healy’s excellent website. It’s important that as many people as possible have the chance to read the piece and take time to watch the film. As far as the pharmaceutical industry is concerned, I can tell you from first hand experience that the industry still believes in its own hype… do more, feel better and live longer is Glaxo’s strapline and no one in that company thinks there’s even a hint of irony in that. Now for Dr Healy’s piece: The Antidepressant Era: the movie The Antidepressant Era was written i...
Source: seroxat secrets... - February 3, 2013 Category: Mental Illness Authors: admin Tags: Drug Marketing Glaxo Uncategorized Big Pharma GlaxoSmithKline Source Type: blogs

TWiV 218: Monkeys turning valves and pushing buttons
On episode #218 of the science show This Week in Virology, Vincent, Alan, and Welkin discuss how endogenous retroviruses in mice are held in check by the immune response. You can find TWiV #218 at www.twiv.tv.
Source: virology blog - February 3, 2013 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology antibody cancer endogenous retrovirus ERV germline murine leukemia virus RAG mouse reactivation TLR toll-like receptor tumor viral Source Type: blogs

Interview with Scanadu’s Chief Medical Officer, Dr. Alan Greene
By now you have probably seen or used (or even built) a device that can be considered part of the Quantified Self movement. It seems that there’s one for every letter of the alphabet, from the Adidas miCoach to the Zeo sleep monitor. The Holy G...
Source: Medgadget - February 4, 2013 Category: Technology Consultants Authors: Shiv Gaglani Tags: Diagnostics Medgadget Exclusive Source Type: blogs

PsycCRITIQUES - Volume 58, Issue 6 is now available online
A new issue of PsycCRITIQUES is available online.If you would like subscription information, please go to http://www.apa.org/pubs/databases/psyccritiques/.If you have a subscription to the product and experience any access problems, please go to http://techhelp.apa.org. February 6, 2013Volume 58, Issue 6 Book Reviews1. Handbook of Psychology (2nd ed.) Author: Irving B. Weiner (Editor-in-Chief) Reviewer: Alan E. Kazdin 2. Inventing Intelligence: How America Came to Worship IQ Author: Elaine E. Castles Reviewer:...
Source: Intelligent Insights on Intelligence Theories and Tests (aka IQ's Corner) - February 5, 2013 Category: Neurologists Source Type: blogs

By Grapthar's Hammer... What a Savings
Andrew J. Coulson Researchers Patrick Wolf and Michael McShane write in the National Review Online today that the DC Opportunity Scholarships Program saves money. They estimate that the ultimate net savings from the private school choice program’s initial 5 year trial period will amount to $113 million ($183 million in savings set against a cost of $70 million). That’s good news, but I, like Alan Rickman’s character in Galaxy Quest, am somewhat ambivalent about this savings figure. What a Savings The trouble is that the real savings are substantially greater, because the above estimate doesn’t ...
Source: Cato-at-liberty - February 6, 2013 Category: Health Medicine and Bioethics Commentators Authors: Andrew J. Coulson Source Type: blogs

Up And Down The Ladder… Job Changes
Hired someone new and exciting? Promoted a rising star? Finally solved that hard-to-fill spot? Share the news with us and we’ll share with it others. That’s right. Send us your announcements and we’ll find a home for them. Don’t be shy. Everyone wants to know who is coming and going, especially with all the layoffs. Despite the downsizing, there is movement. Here are some of the latest changes. Recognize anyone? And here is our regular feature. Send us a photo and we will spotlight a different person each week. This time around, we note that Metrics promoted Joe Cobb Jr. to director of pharmaceutical development. S...
Source: Pharmalot - February 8, 2013 Category: Pharma Commentators Authors: Ed Silverman Tags: Uncategorized Aesica Affymax Amorfix Life Sciences Anthera Pharmaceuticals Avita Medical Cipla HD Smith Human Care Systems Immunotech Laboratories Intarcia Therapeutics Metrics Nimbus Discovery Omni Bio Pharmaceuical PPD Prot Source Type: blogs

The Second Amendment Protects Both Keeping and Bearing Arms
Ilya Shapiro Even before its recent enactment of ill-advised and (at least partially) unconstitutional gun-control measures, New York was no stranger to draconian restrictions on the right to keep and bear arms. The Empire State, like most states, requires a license to carry a handgun outside of one’s home, but differs from many by requiring prospective licensees to show “proper cause” before obtaining a license. State officials have broad discretion in finding such proper cause, which for non-celebrities typically requires proof of extraordinary personal danger documented by threats to one’s life — effective...
Source: Cato-at-liberty - February 11, 2013 Category: Health Medicine and Bioethics Commentators Authors: Ilya Shapiro Source Type: blogs

TWiV 220: Flu watches the clock while T7 gets a CAT scan
On episode #220 of the science show This Week in Virology, Vincent, Rich, Alan, and Kathy discuss regulation of influenza virus replication by splicing, and the bacteriophage T7 random walk. You can find TWiV #220 at www.twiv.tv.
Source: virology blog - February 17, 2013 Category: Virology Authors: Vincent Racaniello Tags: This Week in Virology bacteriophage t7 cryo-electron tomography Cryo-ET influenza NEP NS1 NS2 nuclear export protein rna splicing viral virus Source Type: blogs

Comment on H5N1 lethality in humans
In a brief letter to Biosecurity and Bioterrorism, Alan Zelicoff notes a problem with serosurveys for influenza H5N1 infection: …peak titers after H5N1 infection occur at about 4 to 6 weeks postinfection and may drop by as much as 32-fold over the course of a year, probably decreasing the sensitivity of serologic testing for past asymptomatic infections. Micro-neutralization testing may be more sensitive. He cites a serological survey carried out on poultry workers in South Korea, in which 9 of 2,500 subjects were found to have antibodies to H5N1 virus, in the absence of illness. These seropositive individuals carrie...
Source: virology blog - February 18, 2013 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information avian influenza H5N1 bioterrorism microneutralization serological survey serosurvey viral virus Source Type: blogs

The Nose Knows: Smell Disorders
By Amy Campbell Some of my favorite smells are a Christmas tree, chocolate chip cookies baking in the oven, and freshly cut pumpkins at Halloween — I can't imagine not being able to smell these delightful things. But according to the National Institutes of Health, between 1% and 2% of people in North America say they have a smell disorder. About 25% of men age 60–69 and 11% of women in this same age range have difficulty being able to smell. Not being able to smell, either somewhat or at all, can be dangerous, as our noses alert us to smells that can signal danger, such as a fire, a gas leak, or spoiled food. ...
Source: Diabetes Self-Management - February 19, 2013 Category: Diabetes Authors: Amy Campbell Source Type: blogs

A New Old Diabetes and Obesity Drug Candidate
Obesity is a therapeutic area that has broken a lot of hearts (and wallets) over the years. A scroll back through this category will show some of the wreckage, and there's plenty more out there. But hope does that springing-eternal thing that it does, and there's an intriguing new possibility for a target in this area. Alan Saltiel of Michigan (whose group has had a long presence in this sort of research), along with a number of other well-known collaborators, report work on the inflammation connection between diabetes and obesity: Although the molecular events underlying the relationship between obesity and insulin resis...
Source: In the Pipeline - February 20, 2013 Category: Chemists Tags: Diabetes and Obesity Source Type: blogs

Craving Relief
Why is it so hard for addicts to say “enough?” One of the useful things that may yet come out of the much-derided DSM-5 manual of mental disorders is the addition of craving as a criterion for addiction. “Cravings,” writes Dr. Omar Manejwala, a psychiatrist and the former medical director of Hazelden, “are at the heart of all addictive and compulsive behaviors.” Unlike the previous two volumes in this monthful of addiction books, Manejwala’s book, Craving: Why We Can’t Seem To Get Enough,  focuses on a specific aspect common to all addiction syndromes, and looks at what people might do to lessen its g...
Source: Addiction Inbox - February 28, 2013 Category: Addiction Authors: Dirk Hanson Source Type: blogs

A Life Less Ordinary
“What do you desire? What makes you itch? What sort of a situation would you like? Let’s suppose – I do this often in vocational guidance of students. They come to me and say: ‘Well, um, We’re getting out of college and we haven’t the faintest idea what we want to do.’ So I always ask the question, ‘What would you like to do if money were no object? How would you really enjoy spending your life?’ It’s so amazing, the result of our educational system, that crowds of students say, ‘Well, we’d like to be painters. We’d like to ...
Source: The EMT Spot - March 1, 2013 Category: Ambulance Crew Authors: administrator Tags: The Big Get It slider Source Type: blogs