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Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Delivering Catalase to Treat Sepsis
Sepsis is a state of runaway inflammation in response to infection, a condition that is more serious and more often fatal in older individuals. With age, the immune system becomes every more overactive and inflammatory, reacting to signals created by the damaged environment of the body. This background of chronic inflammation makes it ever less likely that any given incident of greatly raised inflammatory signaling will successfully resolve. Instead inflammation can rage to the point of causing serious harm and organ failure.
At present, treatments for sepsis are largely palliative, or focus on removing the infectio...
Source: Fight Aging! - December 21, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Lack of Funding for Chronic Kidney Disease Research is Not an Outlier
In this commentary, scientists note the paucity of funding for chronic kidney disease research, given the widespread suffering and death caused by this presently incurable condition. This and many other areas of medicine are seen as solved problems by the powers that be simply because there is some form of treatment, even palliative treatment, in widespread use. That the treatment does little and many people die doesn't appear to motivate those who could fund progress. There is no sense of urgency and little sense of need. We might make the same comments in the case of atherosclerosis, a condition many consider to be adequ...
Source: Fight Aging! - November 30, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
If Falls Are a Problem, Look At Medications As a Possible Contributor
Falls are a big fear for older adults because they can be disabling or even fatal. Therefore, looking for reasons behind the falls - other than just age - is important. One potential risk factor is medications, either on their own or in combination. If falls are an issue, it's time to check with the doctor.
Read more on Egosancares for other reasons for falls, as well:
Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver and am reading it slowly on purpose...I don't want it to end.” ...Craig William Dayton, Film Composer
Request a free sample from Egosancar...
Source: Minding Our Elders - September 22, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Roger Chou ’s Undisclosed Conflicts of Interest: How the CDC’s 2016 Guideline for Prescribing Opioids for Chronic Pain Lost Its Clinical and Professional Integrity
by Chad D. Kollas MD, Terri A. Lewis PhD, Beverly Schechtman and Carrie Judy“I ' m present. Uh … I do have a conflict. I receive funding to conduct reviews on opioids, and I ' ll be recusing myself after the um, director ' s, uh, um, um, uh … update.”- Dr. Roger Chou, Center for Disease Control and Prevention (CDC) National Center for Injury Prevention and Control (NCIPC) Board of Scientific Counselors (BSC) Meeting Friday, July 16, 2021.IntroductionFor those familiar with the controversial relationship between the anti-opioid advocacy group, Physicians for Responsible Opioid Prescribing (PROP, recently renamed, He...
Source: Pallimed: A Hospice and Palliative Medicine Blog - September 17, 2021 Category: Palliative Care Tags: CDC judy kollas lewis opioid pain schechtman Source Type: blogs
Roger Chou s Undisclosed Conflicts of Interest: How the CDCs 2016 Guideline for Prescribing Opioids for Chronic Pain Lost Its Clinical and Professional Integrity
by Chad D. Kollas MD, Terri A. Lewis PhD, Beverly Schechtman and Carrie JudyI ' m present. Uh I do have a conflict. I receive funding to conduct reviews on opioids, and I ' ll be recusing myself after the um, director ' s, uh, um, um, uh update.- Dr. Roger Chou, Center for Disease Control and Prevention (CDC) National Center for Injury Prevention and Control (NCIPC) Board of Scientific Counselors (BSC) Meeting Friday, July 16, 2021.IntroductionFor those familiar with the controversial relationship between the anti-opioid advocacy group, Physicians for Responsible Opioid Prescribing (PROP, recently renamed, Health Pro...
Source: Pallimed: A Hospice and Palliative Medicine Blog - September 17, 2021 Category: Palliative Care Tags: CDC judy kollas lewis opioid pain schechtman Source Type: blogs
September is Prostate Cancer Awareness Month: Get Educated!
The prostate, a mall organ located just below the bladder and in front of the rectum, can cause men a lot of anxiety and trouble as they age. It wraps around the urethra (the tube that carries urine and semen out of the body). As men age, the prostate tends to grow larger which can eventually cause any number of health issues including urine retention, but it can become cancerous, as well.
Read more on the Egosancares blog about prostate function and why things go wrong:
Minding Our Elders: Caregivers Share Their Personal Stories. “I hold onto your book as a life preserver and am reading it slowly on purpose...I d...
Source: Minding Our Elders - September 4, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs
Reverse Potts Shunt for Pulmonary Arterial Hypertension in Children
Potts shunt was a surgical anastomosis between left pulmonary artery and descending aorta to improve pulmonary blood flow in cyanotic congenital heart disease with decreased pulmonary blood flow. It is a systemic to pulmonary shunt. The report was published one year after the Blalock-Taussig shunt which was also used for a similar purpose [1]. Later Potts shunt like other central aortopulmonary shunts, were discontinued because of higher risk of excessive pulmonary blood flow. A modified Blalock-Taussig shunt is still in use.
Reverse Potts shunt is a pulmonary to systemic shunt for relieving pulmonary arterial hypertensio...
Source: Cardiophile MD - August 4, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs
How Spiritfarer Helped Me Through the Pandemic
by Matthew Tyler (@PalliDad)During what can only be described as a challenging year, I found Thunderlotus ’s gameSpiritfarer just in the nick of time. In this “cozy management game about dying,” you assume the role of a young woman named Stella who is charged with shuttling spirits to the gates of the afterlife. Unexpectedly,Spiritfarer served as both an escape from and means of processing my experience as a healthcare worker during the pandemic.From top to bottom,Spiritfarer exudes tranquility. The animations are bright and vibrant, and the music is soothing yet melancholy, invoking nostalgia for younger innocent da...
Source: Pallimed: A Hospice and Palliative Medicine Blog - July 14, 2021 Category: Palliative Care Tags: covid grief palliative care pandemic Tyler video games Source Type: blogs
Two Ways to Share your Palliative Care and Hospice Stories
by Christian Sinclair (@ctsinclair)This past few days, I came across two great opportunities that I wanted to share with a wider audience of hospice and palliative care clinicians.First is the podcast and radio show, Radiolab. I ' ve always appreciated the nuance and simplicity the creators can bring to complex issues. They are looking for voice memos from people who work in end-of-life care. They are also looking for patients and families who have been impacted by this work. All you have to do is record a 60-seconds or less voice memo and email it to wnycradiolab@gmail.com. Make sure to include your name, city, and your p...
Source: Pallimed: A Hospice and Palliative Medicine Blog - June 14, 2021 Category: Palliative Care Tags: media sinclair The profession Source Type: blogs
Today is the day you ’ll have to die
She was listless in bed with agonal breathing — only 63 years old. Before stage 4 colon cancer claimed my mother, she chose to come home to her house … her bedroom, where she’d stare out her window at the dogwood trees that symbolized the blood of Jesus. A once-vibrant Italian Catholic and mother ofRead more …Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - June 13, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/debbie-moore-black" rel="tag" > Debbie Moore-Black, RN < /a > < /span > Tags: Conditions Palliative Care Source Type: blogs
PROP s Disproportionate Influence on U.S. Opioid Policy: The Harms of Intended Consequences
ConclusionDespite being turned back from an effort to bluntly reduce opioid prescribing by the FDA in 2013 based on a lack of scientific evidence for its position (17,18), PROP has had a disproportionate effect on opioid policy in the Untied States for almost a decade. PROP found a willing federal regulatory partner in the CDC, and while PROP may not have secretly written the 2016 CDC Pain Guidelines (75), they certainly enjoyed disproportionate representation on CDCs review panels and Core Expert Group (23-25) in a process that lacked transparency (22, 23, 26, 27). When the CDC admitted that its Pain Guideline had been...
Source: Pallimed: A Hospice and Palliative Medicine Blog - May 3, 2021 Category: Palliative Care Tags: CDC health policy kollas opioids pain prop Source Type: blogs
PROP ’s Disproportionate Influence on U.S. Opioid Policy: The Harms of Intended Consequences
ConclusionDespite being turned back from an effort to bluntly reduce opioid prescribing by the FDA in 2013 based on a lack of scientific evidence for its position (17,18), PROP has had a disproportionate effect on opioid policy in the Untied States for almost a decade. PROP found a willing federal regulatory partner in the CDC, and while PROP may not have “secretly written” the 2016 CDC Pain Guidelines (75), they certainly enjoyed disproportionate representation on CDC’s review panels and Core Expert Group (23-25) in a process that lacked transparency (22, 23, 26, 27). When the CDC admitted that its Pain Guideline ha...
Source: Pallimed: A Hospice and Palliative Medicine Blog - May 3, 2021 Category: Palliative Care Tags: CDC health policy kollas opioids pain prop Source Type: blogs
Expressing grief through the power of story PODCAST
“Now the room is silent as if nothing at all occurred. I stand watching the red stain forming on the pristine white sheet, mocking me in my failure. I trained at excellent institutions, survived residency, and served in combat. Now, here at a Level 1 trauma center, I could not save this life with every […]Find jobs at Careers by KevinMD.com. Search thousands of physician, PA, NP, and CRNA jobs now. Learn more.
Source: Kevin, M.D. - Medical Weblog - April 21, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/the-podcast-by-kevinmd" rel="tag" > The Podcast by KevinMD < /a > < /span > Tags: Podcast Palliative Care Source Type: blogs
