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Fight Aging! Newsletter, September 4th 2023
In conclusion, although the contribution of CRF to GrimAgeAccel and FitAgeAccel is relatively low compared to lifestyle-related factors such as smoking, the results suggest that the maintenance of CRF is associated with delayed biological ageing in older men. « Back to Top Release of Acetylcholine is Necessary for the Aging Brain to Compensate for a Lack of Neurogenesis https://www.fightaging.org/archives/2023/09/release-of-acetylcholine-is-necessary-for-the-aging-brain-to-compensate-for-a-lack-of-neurogenesis/ Neurogenesis is the process by which new neurons are created by neural stem ce...
Source: Fight Aging! - September 3, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 13th 2023
This study investigated whether taller Polish adults live longer than their shorter counterparts. Data on declared height were available from 848,860 individuals who died in the years 2004-2008 in Poland. To allow for the cohort effect, the Z-values were generated. Separately for both sexes, Pearson's r coefficients of correlation were calculated. Subsequently, one way ANOVA was performed. The correlation between adult height and longevity was negative and statistically significant in both men and women. After eliminating the effects of secular trends in height, the correlation was very weak (r = -0.0044 in men and ...
Source: Fight Aging! - February 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 29th 2022
This study demonstrates that adoptive astrocytic Mt transfer enhances neuronal Mn-SOD-mediated anti-oxidative defense and neuroplasticity in the brain, which potentiate functional recovery following ICH. First Generation Stem Cell Therapies Remain Comparatively Poorly Understood https://www.fightaging.org/archives/2022/08/first-generation-stem-cell-therapies-remain-comparatively-poorly-understood/ We are something like thirty years into the increasingly widespread use of first generation stem cell therapies. Cells are derived from a variety of sources, processed, and transplanted into patients. Near all ...
Source: Fight Aging! - August 28, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Weekly Overseas Health IT Links – 26th March, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.-----https://mhealthintelligence.com/news/55-of-telehealth-providers-frustrated-with-overblown-patient-expectations55% of Telehealth Providers Frustrated With Overblown Patient ExpectationsProviders also cited their ability to provide quality care and technical difficulties as among their top frustrations with telehealth, a new survey shows.ByAnuja VaidyaMarch 18, 202...
Source: Australian Health Information Technology - March 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

What the Pandemic Taught Us About Value-based Care
By RICHARD ISSACS You’ll recall that we ran a long piece (pt 1, pt 2) about Medicare Advantage from former Kaiser Permanente CEO George Halvorson earlier this year. Here’s a somewhat related piece from the current head of the Permanente Medical Group about what actually happened there and elsewhere during the pandemic–Matthew Holt The COVID-19 pandemic has provided important lessons regarding the structure and delivery of health care in the United States, and one of the most significant takeaways has been the need to shift to value-based models of care. The urgency for this transformation was cle...
Source: The Health Care Blog - February 17, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice Physicians Kaiser Permanente Medicare Advantage Pandemic Richard Isaacs value-based care Source Type: blogs

Fight Aging! Newsletter, June 14th 2021
In conclusion, a number of high-income countries, changes in health expectancies over time have not kept pace with the growth in life expectancy. That is, people are living longer but disability and poor health are occupying an increasing proportion of later life. Our findings suggest that countries still need to make significant progress to achieve the WHO's Decade of Healthy Ageing goal of healthier, longer lives for all. Progress on Understanding Why Human Growth Hormone Receptor Variants are Associated with Greater Longevity https://www.fightaging.org/archives/2021/06/progress-on-understanding-why-human-gro...
Source: Fight Aging! - June 13, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Post #55 COVID-19 Vaccine for 12 to 15 Year Old Adolescents
The Pfizer vaccine will soon be offered to 12-15 year olds, raising a mild conundrum for parents.Should they skip the vaccine, given that most children have fared well when infected with COVID-19 (many already having been infected)?  Or should they immunize their child(ren), even though the vaccine is relatively new and doesn ’t have a long track record?Vaccines have had their missteps, most notably the recalled RotaShield immunization in 1999. However, the recall of RotaShield and the recent temporary pause of the Johnson&Johnson COVID-19 vaccine should instill confidence in the robustness and capability o...
Source: A Pediatrician's Blog - May 8, 2021 Category: Pediatrics Source Type: blogs

Fully vaccinated against COVID-19? So, what can you safely do?
Congrats on getting your COVID-19 vaccine! You qualify as fully vaccinated two weeks after your second dose of the Moderna or Pfizer/BioNTech vaccine, or two weeks after your single dose of the Johnson & Johnson vaccine, according to the US Centers for Disease Control and Prevention (CDC). Maybe you’re wondering what you can safely do now that you’re fully vaccinated. As an infectious disease specialist, I’ve provided answers to some common questions. Please keep in mind that information about COVID-19 and vaccines is evolving, and recommendations may change as we learn more. Can I gather with people outside my h...
Source: Harvard Health Blog - March 25, 2021 Category: Consumer Health News Authors: Amy C. Sherman, MD Tags: Coronavirus and COVID-19 Health Parenting Relationships Vaccines Source Type: blogs

Fight Aging! Newsletter, March 1st 2021
This study may have important implications for preventing cell senescence and aging-induced tendinopathy, as well as for the selection of novel therapeutic targets of chronic tendon diseases. Our results showed that the treatment of bleomycin, a DNA damaging agent, induced rat patellar TSC (PTSC) cellular senescence. The senescence was characterized by an increase in the senescence-associated β-galactosidase activity, as well as senescence-associated changes in cell morphology. On the other hand, rapamycin could extend lifespan in multiple species, including yeast, fruit flies, and mice, by decelerating DNA damage ...
Source: Fight Aging! - February 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, February 22nd 2021
In conclusion, long term LRIC could decrease blood pressure and ameliorate vascular remodeling via inflammation regulation. The Damage of a Heart Attack Causes the Immune System to Overreact https://www.fightaging.org/archives/2021/02/the-damage-of-a-heart-attack-causes-the-immune-system-to-overreact/ Researchers here note a mechanism that causes T cells of the adaptive immune system to spur chronic inflammation and tissue damage following a heart attack. As the researchers note, not all inflammation is the same. Some is maladaptive, and this is particularly the case in older individuals. The aged immune...
Source: Fight Aging! - February 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

All you need to know about waterborne diseases
  Waterborne diseases are contracted through exposure to contaminated water including drinking water, water used in food preparation, and swimming water.  They can be caused by bacteria, viruses, and parasites. Below is a partial list of waterborne disease pathogens, their microbial classification, and their resulting illnesses. Classification Microorganism Disease Bacterium Campylobacter spp. Campylobacteriosis Bacterium Escherichia coli E. Coli Diarrhea Bacterium Legionella pneumophila Legionnaires’ Disease Bacterium Salmonella enterica Salmonellosis Bacterium Salmonella typhi Typhoid fever ...
Source: GIDEON blog - January 14, 2021 Category: Databases & Libraries Authors: Kristina Symes Tags: Microbiology News Tips Source Type: blogs

What I Got Wrong (and Right) about COVID19
In May, I wrote a column about COVID19 that got some attention. My reason for writing was the change in messaging about the strategy of flatten-the-curve. We were first told to flatten-the-curve to prevent overwhelming hospitals. But then the thinking changed to flatten-the-curve to save lives.  I made eight assertions about COVID19. Let’s see how I did.  Assertion 1: The virus will not be contained. Verdict: Correct. You might argue that New Zealand and Australia contained the virus, but I would counter that these are not fair comparisons to the US, Canada, and the EU.  Assertion 2: Tests...
Source: Dr John M - December 12, 2020 Category: Cardiology Authors: Dr John Source Type: blogs

Common cold, flu, or coronavirus?
  In the early days of the outbreak, the novel coronavirus (COVID-19) was repeatedly compared to the flu (influenza) and even to the common cold (rhinoviruses, et al). This was due to an initial impression of shared symptoms. The differences between these conditions are particularly important as we kick off National Influenza Vaccination Week (NIVW) and the ‘flu season’. So, how can we tell which of these diseases we are dealing with in a given patient?     Common cold Let’s start with the common cold, a condition that can be caused by over 200 different strains of viruses.  On average, an adult wil...
Source: GIDEON blog - December 8, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Diagnosis Identify News Source Type: blogs