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Long-term effects of Ebolavirus infection
This study only included adults; children who have recovered should also be examined as their health care needs may be different. These results confirm that there are long-term sequelae of Ebolavirus infection. The basis for the complications is not known, but is likely a consequence of tissue damage due to viral replication and the immune response. Whether or not virus was present in the patients was not determined. However it is known that Ebolavirus can persist in the testicles and eye long after it is absent from serum. Other serious viral infections are also accompanied by long term health effects. For example, 29% of...
Source: virology blog - June 19, 2015 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information acute arthralgia Ebola ebolavirus long term myalgia persistent symptoms uveitis viral Source Type: blogs

The Trans-Pacific Partnership: A Threat To Global Health?
Lost in the political discussions over the passage of the Trans-Pacific Partnership (TPP)—a trade agreement currently being negotiated in secret between the U.S. and 11 other Pacific-Rim nations—is the very real negative impact it would have on global health. Doctors Without Borders/Médecins Sans Frontières (MSF) works in over 60 countries, and our medical teams rely on access to affordable medicines and vaccines. We are deeply concerned that the TPP, in its current form, will lock-in high, unsustainable drug prices, block or delay the availability of affordable generic medicines, and price millions of people...
Source: Health Affairs Blog - May 8, 2015 Category: Health Management Authors: Deane Marchbein Tags: Drugs and Medical Technology Equity and Disparities Featured Global Health Public Health Doctors Without Borders fair trade generic drugs obama trade deal TPP Trans-Pacific Trade Partnership Source Type: blogs

Meet Nels Elde and His Team’s Amazing, Expandable Viruses
Credit: Kristan Jacobsen Nels Elde, Ph.D. Fields: Evolutionary genetics, virology, microbiology, cell biology Works at: University of Utah, Salt Lake City When not in the lab, he’s: Gardening, supervising pets, procuring firewood Hobbies: Canoeing, skiing, participating in facial hair competitions “I really look at my job as an adventure,” says Nels Elde. “The ability to follow your nose through different fields is what motivates me.” Elde has used that approach to weave evolutionary genetics, bacteriology, virology, genomics and cell biology into his work. While a graduate student at the University of Chica...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 7, 2015 Category: Research Authors: Srivalli Subbaramaiah Tags: Cell Biology Genetics Profiles Source Type: blogs

Health Cooperation In The New U.S.-Cuban Relationship
Four months after the surprise announcement of his determination to normalize relations with Cuba, President Barack Obama is rapidly translating that wish into reality, with the cooperation of Cuban counterparts and widespread support among Americans. On April 11, the Summit of the Americas featured the first meeting of the two countries’ presidents in over fifty years. Three days later, even amidst a struggle with Congress over a possible nuclear deal with Iran, the Obama administration announced it will remove Cuba from the U.S. list of state sponsors of terrorism, a step Carl Meacham, Director of the Center for Strate...
Source: Health Affairs Blog - April 29, 2015 Category: Health Management Authors: J. Stephen Morrison Tags: Featured Global Health Bill Frist Cuba cuban health care Raúl Castro U.S.-Cuban relationship Source Type: blogs

FDA Acting Commissioner Ostroff Addresses the "State of the FDA"
The 2015 FDLI Annual Conference kicked off yesterday in Washington, DC. The conference hosted a variety of impressive speakers from the Food and Drug Administration, as well as FDA lawyers and in-house counsel. Dr. Stephen Ostroff, the Acting Commissioner at FDA, spoke as the conference's keynote speaker. After congratulating previous Commissioner Margaret Hamburg on an impressive tenure as FDA Commissioner, Ostroff ran through a long list of recent FDA accomplishments--"hitting the highlights," as he called it. Following Ostroff's address, a panel of industry experts provided a "to do list" for the agency for the co...
Source: Policy and Medicine - April 21, 2015 Category: American Health Authors: Thomas Sullivan Source Type: blogs

FDA seeks $4.9 billion for FY 2016; Commissioner Hamburg Reflects on FDA's Accomplishments Over the Past Year
Dr. Margaret Hamburg will step down from her post as Commissioner of the FDA next month. Hamburg and the FDA were busy in the few days before the announcement of her resignation, however. The Agency released a budget request for FY 2016, and Hamburg wrote a recap of the FDA's past year. Below is a summary of both.  FDA's Budget for FY 2016 In FDA's budget request, Hamburg stated that the agency is requesting a total of $4.9 billion, including a $148 million budget authority to: increase focus on improved oversight of imported foods, combat the growing threat of antibiotic resistance, promote the dev...
Source: Policy and Medicine - February 6, 2015 Category: American Health Authors: Thomas Sullivan Source Type: blogs

Illuminating Biology
This time of year, lights brighten our homes and add sparkle to our holidays. Year-round, scientists funded by the National Institutes of Health use light to illuminate important biological processes, from the inner workings of cells to the complex activity of the brain. Here’s a look at just a few of the ways new light-based tools have deepened our understanding of living systems and set the stage for future medical advances. A new fluorescent probe shows viral RNA (red) in an RSV-infected cell. Credit: Eric Alonas and Philip Santangelo, Georgia Institute of Technology and Emory University. Visualizing Viral Activity...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - December 29, 2014 Category: Research Authors: Srivalli Subbaramaiah Tags: Cell Biology Cool Images Source Type: blogs

Does Public Health Have A Future?
Ebola’s arrival in the U.S. hit Americans with a jolt. Regardless of how you feel about the response to date, it should remind everyone of the importance of public health. Fortunately, public health in the U.S. has built an extraordinary track record of success. Smallpox, one of the most dreaded diseases in history, was eradicated worldwide. New vaccines have sharply cut the toll of deaths and disabilities from H flu meningitis, tetanus, pneumococcal sepsis and other deadly diseases. Adding folate to foods dramatically reduced neural tube defects in newborns. Safer cars and better roadway designs cut fatal crashes per m...
Source: Health Affairs Blog - December 10, 2014 Category: Health Management Authors: Arthur Kellermann and Mark Kortepeter Tags: All Categories Environmental Health Prevention Public Health Source Type: blogs

Could Reston virus be a vaccine for Ebola virus?
I have received many questions about whether immunizing with Reston virus could protect against infection with Ebola virus. Usually the question comes together with the statement ‘because Reston virus does not cause disease in humans’. I can think of two reasons why a Reston virus vaccine is not a good idea. There have been very few confirmed human infections with Reston virus (4 according to Fields Virology 6th Edition), and although these individuals did not show signs of disease, the number is too small to make any conclusions. For example, if the case fatality ratio of Reston virus in humans were 1%, we mi...
Source: virology blog - October 23, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information Bundibugyo ebola virus ebolavirus Reston Sudan Tai Forest vaccine viral Source Type: blogs

How Firestone controlled Ebola virus disease in Liberia
When the first case of Ebola virus infection was detected at the Firestone Liberia, Inc. rubber tree plantation in March of this year, the company needed to prevent the virus from spreading among their 8,500 employees. The company established an incident management system, developed procedures for early detection of infection, enforced infection control guidelines, and provided different levels of management for contacts depending on their exposure. The company did a remarkable job of isolating and caring for patients and limiting transmission to health care workers and family members. A description of this program, just i...
Source: virology blog - October 21, 2014 Category: Virology Authors: Vincent Racaniello Tags: Information ebola virus ebolavirus Firestone Liberia Inc. infection control rubber tree plantation viral virology Source Type: blogs

No #AAAS and ASM you do not deserve good PR for freeing up a few papers on Ebola
Saw a PR from AAAS about how they were freeing up all of ~ 20 papers on Ebola In light of what has become the largest Ebola outbreak on record, Science and Science Translational Medicine have compiled over a decade's worth of their published news and research. Researchers and the general public can now view this special collection for free.OK. More access is good. But alas, they did not even free up all papers in #AAAS journals with Ebola in the Title or Abstract.And then I started thinking. What about HIV? TB? Malaria? And as I started Tweeting about this, I saw that ASM also was hopping on the "free Ebola" bandwagon (act...
Source: The Tree of Life - August 20, 2014 Category: Medical Scientists Authors: Jonathan Eisen Source Type: blogs

Ebolavirus vaccines and antivirals
As the epidemic of Zaire ebolavirus in Western Africa continues (1,779 cases and 961 deaths in four countries), many are questioning why there are no means of preventing or stopping infection. In the past two decades there has been substantial research into developing and testing active and passive vaccines and antiviral drugs, although none have yet been licensed for use in humans. Using antibodies to treat infection with ebolaviruses with antibodies is probably the best known therapy, because it was used to treat a two Americans who were infected while working in Liberia. They received a mixture of three monocl...
Source: virology blog - August 8, 2014 Category: Virology Authors: Vincent Racaniello Tags: Basic virology Information antiviral ebola virus ebolavirus filovirus Guinea hemorrhagic fever Liberia monoclonal antibody therapy Sierra Leone vaccine ZMapp Source Type: blogs

Can Gingko and Turmeric Help Stop Ebola?
Summary There is no known pharmaceutical currently available that specifically treats Ebola disease. One treatment modality that should be considered is the use of herbal medicines, which have both centuries old anecdotal success as well as recent modern biochemical and formal research rationales for their use. Five areas of action that could be addressed by the herbal medicines as it relates to Ebola would be: VP24/immune system evasion GP protein/replicatio; herbal strategies effective against similar hemorrhagic disease beneficial modulation of patient immune and inflammatory response systems prophylactic use for heal...
Source: Inside Surgery - August 1, 2014 Category: Surgery Authors: Editor Tags: Infectious Disease ayurvedic baicalen cathepsin b dengue Ebola gingko herb Quercetin resveratrol rosemary sage st johns work turmeric Source Type: blogs

Can Rife Therapy Help Stop Ebola Disease?
Ebola disease. As the world watches with increasing horror the slow but sure spread of this killer, health authorities are struggling with how best to treat the afflicted while maintaining strict isolation and quarantine. Distressingly, many healthcare workers taking care of ill Ebola disease patients have themselves been infected and are in mortal danger, including Americans Dr. Kent Brantly and Nancy Writebol, aid workers for the charity Samaritan’s Purse. The Ebola disease is highly infectious, meaning once a patient comes in contact with the virus, a severe illness almost always develops. Patient commonly develo...
Source: Inside Surgery - August 1, 2014 Category: Surgery Authors: Editor Tags: Infectious Disease cure Ebola kent brantly nancy writebol PERL Rife samaritans purse treatment vaccine Source Type: blogs

No Treatment or Vaccine for Ebola, but a $1000 Pill for Hepatitis C
The Ebola virus epidemic in West Africa continues to grow, and now appears to be the worst known epidemic of that disease to date.  In the US and Western Europe, press reports are now raising concerns that the disease could spread there.  For example, CNN, in an article entitled "Ebola Fears Hits Close to Home," was a section headed "Could Ebola spread to the US?" An ABC article was entitled, "How the US Government Could Evacuate Americans with Ebola."Reasons for fear of spread are the increased mobility of people made possible by air travel, and the lack of specificity of early symptoms of Ebola, so infectious p...
Source: Health Care Renewal - July 31, 2014 Category: Health Management Tags: Ebola virus economism hepatitis C neoliberalism pharmaceuticals Sovaldi Source Type: blogs