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Fight Aging! Newsletter, October 16th 2017
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - October 15, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Funtabulously Frivolous Friday Five 207
LITFL • Life in the Fast Lane Medical Blog LITFL • Life in the Fast Lane Medical Blog - Emergency medicine and critical care medical education blog Just when you thought your brain could unwind on a Friday, you realise that it would rather be challenged with some good old fashioned medical trivia FFFF…introducing Funtabulously Frivolous Friday Five 207. Question 1 Which animal has saved the most human lives? + Reveal the Funtabulous Answer expand(document.getElementById('ddet1756567646'));expand(document.getElementById('ddetlink1756567646')) Horseshoe Crab If you’ve ever had an injection you probably owe ...
Source: Life in the Fast Lane - September 29, 2017 Category: Emergency Medicine Authors: Neil Long Tags: Frivolous Friday Five Anatomy Boerhaave Burke and Hare horseshoe crab LAL limulus amebocyte lysate murder ophthalmophantome plane crash Source Type: blogs

Fight Aging! Newsletter, August 14th 2017
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more. This content is...
Source: Fight Aging! - August 13, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, August 7th 2017
Discussions of radical life extension, technological acceleration, and artificial general intelligence were far more fringe concerns back then than is now the case, but this growth in awareness isn't a coincidence. Visions slowly become reality because people work to make that happen. Technological progress is not accidental: it is led by our desires. I should say that de Magalhães is here generous in not passing judgement on the value (or lack thereof) of most of the various ventures and classes of approach he surveys. But some approaches are definitely better than others, and to my eyes one the principal challeng...
Source: Fight Aging! - August 6, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Short Interview with George Church on Genetics and the Treatment of Aging
The Life Extension Advocacy Foundation volunteers recently interviewed George Church, one of the leaders in the research community who has come around these past few years to speak out in public as being very much in favor of treating aging as a medical condition. I point this out largely because they ask about some of his recent comments regarding timelines in the near future development of anti-aging therapies. He thinks that the first are only a few years away, which is indeed true from my perspective given what is happening in the development of senolytics to clear senescent cells, but Church doesn't have senolytics in...
Source: Fight Aging! - August 2, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Doctors Do Know Best. Exhibit A: The Charlie Gard Case.
By SAURABH JHA, MD For American conservatives, Britain’s NHS is an antiquated Orwellian dystopia. For Brits, even those who don’t love the NHS, American conservatives are better suited to spaghetti westerns, such as Fistful of Dollars, than reality. The twain is unlikely to meet after the recent press surrounding Charlie Gard the infant, now deceased, with a rare, fatal mitochondrial disorder in which mitochondrial DNA is depleted – mitochondrial depletion disorder (MDD). In this condition, the cells lose their power supply and tissues, notably in the brain, die progressively and rapidly. The courts forbade Charlieâ...
Source: The Health Care Blog - July 31, 2017 Category: Consumer Health News Authors: at RogueRad Tags: OP-ED Patients Source Type: blogs

Fight Aging! Newsletter, July 31st 2017
In conclusion, documentation is important, a critical part of advocacy and the development process at the larger scale. It isn't just words, but rather a vital structural flow of information from one part of the larger community to another, necessary to sustain progress in any complex field. We would all do well to remember this - and to see that building this documentation is an activity in which we can all pitch in to help. Evidence Suggests that, at Least in Earlier Stages, Alzheimer's Disease Blocks Rather than Destroys Memories https://www.fightaging.org/archives/2017/07/evidence-suggests-that-at-least-in-ea...
Source: Fight Aging! - July 30, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Brand new nontoxic radiopaque glue to seal bleeding and guide surgery
As open surgery procedures have gradually been replaced by minimally invasive and image-guided procedures, tissues adhesives are taking the place of sutures and surgical staples. These have got countless applications, including bleeding embolization, angioplasty, stent insertion, and biopsies, among others. Such new surgical glues are highly desired in healthcare clinics. Researchers at the Center with regard to Nanoparticle Research, within the Institute just for Basic Science (IBS) in collaboration with medical doctors in Seoul Nationwide University Hospital, have created a medical glue that is both adherent plus visible...
Source: My Irritable Bowel Syndrome Story - July 19, 2017 Category: Gastroenterology Authors: Ken Tags: IBS News Source Type: blogs

Fight Aging! Newsletter, July 10th 2017
This article covers some of the advances of recent years in understanding the effects of varied forms of calorie restriction in humans. Efforts to quantify the results and find a good 80/20 point, at which most of the effects of longer and more stringent reductions in calorie intake are still evident, have resulted in practical outcomes. A number of quite interesting discoveries have been made along the way, such as the ability of longer fasting periods to clear out and replace damaged immune cells to some degree. The second phase of the Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (C...
Source: Fight Aging! - July 9, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 29th 2017
In this study, we utilized an imaging-based assay to monitor the ability of disease-associated amyloid assemblies to rupture intracellular vesicles following endocytosis. We observe that the ability to induce vesicle rupture is a common feature of α-synuclein (α-syn) assemblies, as assemblies derived from wild type (WT) or familial disease-associated mutant α-syn all exhibited the ability to induce vesicle rupture. Similarly, different conformational strains of WT α-syn assemblies, but not monomeric or oligomeric forms, efficiently induced vesicle rupture following endocytosis. The ability to induce vesicle rupt...
Source: Fight Aging! - May 28, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

In Essence, All Aging Research Revolves around the Science and Advocacy of SENS, the Strategies for Engineered Negligible Senescence
Today's popular science article for consideration is the usual mix of frustrating and interesting remarks that result when various researchers are convinced to talk to the press on the subject of SENS rejuvenation research. I in no way exaggerate when I say that all approaches to the research of aging, all of the intent in aging research, all of the fundamental disagreements in the field, ultimately revolve around SENS, the Strategies for Engineered Negligible Senescence. The advocacy and the science of SENS are the moral and technological sun in this solar system, for all that many of those orbiting it apparently would ra...
Source: Fight Aging! - May 25, 2017 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs

Fight Aging! Newsletter, May 22nd 2017
In this study, researchers analysed data of millions of British patients between 1995 and 2015 to see if this claim held true. They tracked people who were obese at the start of the study, defined as people with a body mass index (BMI) of 30 or more, who had no evidence of heart disease, high blood pressure, high cholesterol or diabetes at this point. They found these people who were obese but "metabolically healthy" were at higher risk of developing heart disease, strokes and heart failure than people of normal weight. No such thing as 'fat but fit', major study finds Several studies in the past have sug...
Source: Fight Aging! - May 21, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Interleukin-7 and Immunosenescence
Researchers here examine what is known of the role of interleukin-7 (IL-7) in the gradual decline and malfunction of the aging immune system. In the old, the immune system is both more active, producing chronic inflammation that drives the progression many of the most common age-related diseases, and at the same time less effective at carrying out its tasks. This is a major component of the frailty of old age. In the bigger picture, this is a story of molecular damage, misconfiguration of immune cells, and resulting disarray in the regulation of the immune response, but the low-level details of this progressive functional ...
Source: Fight Aging! - May 12, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, May 8th 2017
This report captures the state of the research community in a nutshell: progress in the sense that ever more scientists are willing to make the treatment of aging the explicit goal of their research, but, unfortunately, there is still a long way to go in improving the nature of that research. It is still near entirely made up of projects that cannot possibly produce a robust and large impact on human life span. The only course of action likely to extend life by decades in the near future is implementation of the SENS vision for rejuvenation therapies - to repair the molecular damage that causes aging. Everything else on th...
Source: Fight Aging! - May 7, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 1st 2017
In this study we demonstrate the use of clustered regularly interspaced short palindromic repeats (CRISPR)-based epigenome editing to alter cell response to inflammatory environments by repressing inflammatory cytokine cell receptors, specifically TNFR1 and IL1R1. This has applications for many inflammatory-driven diseases. It could be applied for arthritis or to therapeutic cells that are being delivered to inflammatory environments that need to be protected from inflammation." In chronic back pain, for example, slipped or herniated discs are a result of damaged tissue when inflammation causes cells to create molec...
Source: Fight Aging! - April 30, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs