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HERVs role in the pathogenesis, diagnosis or prognosis of aging diseases: A systematic review
In conclusion, the results suggested that HERVs play a role in the pathogenesis and can be used as biomarkers for diagnosis or prognosis of aging disorders.PMID:35619278 | DOI:10.2174/1566524022666220525144135
Source: Current Molecular Medicine - May 27, 2022 Category: Molecular Biology Authors: Paula Prieto-Oliveir Source Type: research

Patient-Reported Care Coordination is Associated with Better Performance on Clinical Care Measures
ConclusionsWithin health plans, beneficiaries who report better care coordination also received higher-quality clinical care, particularly for care processes that entail organizing patient care activities and sharing information among different healthcare providers. These results extend prior research showing that health plans with better beneficiary-reported care coordination achieved higher HEDIS performance scores.
Source: Journal of General Internal Medicine - September 20, 2021 Category: Internal Medicine Source Type: research

Transretinal biopsy via 23-gauge pars plana vitrectomy for retinal and choroidal tumors: cytopathological results, surgical complications, and patient outcomes
ConclusionsTRB using 23 G pars plana vitrectomy  can be used to make the cytopathologic diagnosis of retinal/choroidal tumors whenever the clinical diagnosis is not certain or in cases with known diagnosis to obtain information on cell type/cytogenetics. In our series, the most common diagnosis after cytopathologic examination was choroidal mel anoma.
Source: Japanese Journal of Ophthalmology - January 9, 2021 Category: Opthalmology Source Type: research

Perspectives on the Classical Enzyme Carbonic Anhydrase and the Search for Inhibitors.
Abstract Carbonic anhydrase (CA) is a thoroughly studied enzyme. Its primary role is the rapid interconversion of carbon dioxide and bicarbonate in the cells, where carbon dioxide is produced, and in the lungs, where it is released from the blood. At the same time, it regulates pH homeostasis. The inhibitory function of sulfonamides on CA was discovered some 80 years ago. There are numerous physiological-therapeutic conditions in which inhibitors of carbonic anhydrase have a positive effect, such as glaucoma, or act as diuretics. With the realization that several isoenzymes of carbonic anhydrase are associated wit...
Source: Biophysical Journal - August 26, 2020 Category: Physics Authors: Jonsson BH, Liljas A Tags: Biophys J Source Type: research

CDKN2B-AS1: An indispensable long non-coding RNA in multiple diseases.
CONCLUSIONS: Long non-coding RNA CDKN2B-AS1 likely serves as a promising therapeutic target or prognosis biomarker in multiple human diseases. PMID: 32767927 [PubMed - as supplied by publisher]
Source: Current Pharmaceutical Design - August 4, 2020 Category: Drugs & Pharmacology Authors: Song C, Qi Y, Zhang J, Guo C, Yuan C Tags: Curr Pharm Des Source Type: research

Exploring the impact of public health campaigns for glaucoma and macular degeneration utilising Google Trends data in a New Zealand setting.
CONCLUSIONS: Glaucoma and macular degeneration search behaviour in New Zealand has a low impact following health awareness campaigns in comparison to breast and prostate cancer. This implies there is scope for improvement with these campaigns and a large increase in macular degeneration activity following a public meeting, and report release suggests that increased funding may increase impact. This study also highlights the utility of internet data for cost-effective monitoring of public interest in health issues. PMID: 32379735 [PubMed - in process]
Source: New Zealand Medical Journal - May 9, 2020 Category: General Medicine Tags: N Z Med J Source Type: research

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