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Impact of Type 2 diabetes mellitus and insulin use on progression to glaucoma surgery in primary open angle glaucoma
Eye, Published online: 22 September 2023; doi:10.1038/s41433-023-02734-2Impact of Type 2 diabetes mellitus and insulin use on progression to glaucoma surgery in primary open angle glaucoma
Source: Eye - September 22, 2023 Category: Opthalmology Authors: Michelle T. Sun Suzann Pershing Jeffrey L. Goldberg Sophia Y. Wang Source Type: research

At a glance
Extending the utility of anterior corneal buttons through refrigeration and glycerol cryopreservation: utility rate and outcome analysis (see page 1415) Glycerol cryopreservation can safely extend the utility of donor anterior corneal grafts for up to two years. This method not only reduced the wastage of scarce donor corneal tissue but also was cost effective. Clinical course and treatment of archipelago keratitis: a Herpesviridae keratitis subtype (see page 1419) Archipelago keratitis is a Herpesviridae stromal keratitis subtype associated with a high recurrence rate, requiring antiviral and anti-inflammatory drugs over ...
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Larkin, F. Tags: Highlights from this issue Source Type: research

Effect of eyelid muscle action and rubbing on telemetrically obtained intraocular pressure in patients with glaucoma with an IOP sensor implant
Conclusion Eyelid manoeuvres in patients with POAG elicited brief increases in IOP that were particularly large with squeezing and rubbing. Further investigation of the potential implications for glaucoma progression is warranted.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: van den Bosch, J. J. O. N., Pennisi, V., Mansouri, K., Weinreb, R. N., Thieme, H., Hoffmann, M. B., Choritz, L. Tags: Open access Original articles - Clinical science Source Type: research

Neurofilament light chain: a new marker for neuronal decay in the anterior chamber fluid of patients with glaucoma
Conclusion NfL levels in anterior chamber fluid are elevated in patients with glaucoma and correlate with intraocular pressure and retinal nerve fibre layer thickness. The presented data strongly support anterior chamber fluid NfL as a new marker for glaucoma.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Woltsche, N., Valentin, K., Hoeflechner, L., Guttmann, A., Horwath-Winter, J., Schneider, M. R., Ivastinovic, D., Lindner, M., Schmetterer, L., Singh, N., Riedl, R., Buchmann, A., Khalil, M., Lindner, E. Tags: Original articles - Clinical science Source Type: research

Parapapillary choroidal microvascular density in acute primary angle-closure and primary open-angle glaucoma: an optical coherence tomography angiography study
Conclusions While superficial peripapillary vessels were affected to similar degrees in POAG and APAC, PPCMv drop-out was greater with POAG versus APAC, suggesting that choroidal vessel density may be affected to a lesser extent following an acute increase in intraocular pressure before glaucoma develops.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Suwan, Y., Aghsaei Fard, M., Vilainerun, N., Petpiroon, P., Tantraworasin, A., Teekhasaenee, C., Ritch, R., Kafieh, R., Hojati, S., Supakontanasan, W. Tags: Open access Original articles - Clinical science Source Type: research

Factors associated with choroidal microvascular dropout change
Conclusion Greater IOP fluctuation, higher peak IOP, worse baseline VF MD and greater number of glaucoma medications were significantly associated with MvD enlargement in glaucomatous eyes. The identification of factors associated with MvD enlargement may improve our understanding of the role of choroidal vasculature in glaucoma.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Micheletti, E., Moghimi, S., Nishida, T., El-Nimri, N., Mahmoudinedzah, G., Kamalipour, A., Mohammadzadeh, V., Zangwill, L. M., Weinreb, R. N. Tags: Original articles - Clinical science Source Type: research

Cost-effectiveness of primary surgical versus primary medical management in the treatment of patients presenting with advanced glaucoma
Conclusion This is the first study to evaluate management strategies for those presenting with advanced glaucoma. At a 2-year time horizon, medication is the more cost-effective approach for managing glaucoma. Future research can focus on the costs and benefits of the treatments over a longer time horizon.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Kernohan, A., Homer, T., Shabaninejad, H., King, A. J., Hudson, J., Fernie, G., Azuara-Blanco, A., Burr, J., Sparrow, J. M., Garway-Heath, D., Barton, K., Norrie, J., Maclennan, G., Vale, L. Tags: Open access Original articles - Clinical science Source Type: research

Glaucoma in rural China (the Rural Epidemiology for Glaucoma in China (REG-China)): a national cross-sectional study
Conclusions Rural populations have a high prevalence of glaucoma, which should be included in chronic disease management programmes in China for long-term care.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Liu, Y., Yao, B., Chen, X., Yang, X., Liu, Y., Xie, Z., Chen, X., Yuan, Z., Wang, X., Hu, D., Ma, X., Gao, W., Wang, R., Yang, Y., Chen, S., Zhang, J., Song, Z., Wang, J., Wang, J., Pei, J., Wang, W., Wang, M., Gao, J., Zhang, H., Tan, L., Du, W., Pan, X. Tags: Original articles - Clinical science Source Type: research

Hand grip strength and ocular associations: the Ural Eye and Medical Study
Conclusions and relevance In addition to parameters such as lower physical activity, higher depression score and worse general health status, a reduced HGS is associated with visual impairment, shorter axial length, lower intraocular pressure, thinner peripapillary retinal nerve fibre layer and higher prevalence of diabetic retinopathy. HGS dynamometry or a handshake may provide the ophthalmologist additional clinical information about the general health and ocular parameters of the patient.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Bikbov, M. M., Zainullin, R. M., Gilmanshin, T. R., Iakupova, E. M., Kazakbaeva, G. M., Panda-Jonas, S., Tuliakova, A. M., Fakhretdinova, A. A., Gilemzianova, L. I., Jonas, J. B. Tags: Original articles - Clinical science Source Type: research

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in irreversible vision loss due to the mammalian central nervous system ’s limited regenerative capacity. RGC repopulation is a...
Source: Molecular Neurodegeneration - September 21, 2023 Category: Neurology Authors: Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Tags: Review Source Type: research

Impact of Type 2 Diabetes Mellitus-Related Factors on Glaucoma: a Comprehensive Review
AbstractPurposeTo investigate the contradictory association of glaucoma with type 2 diabetes mellitus (T2DM) and its related factors that have been a springboard for a number of complications including glaucoma. Also, to examine the neuroprotective effects of antidiabetic medications.Recent FindingsRecent studies suggest that T2DM may alleviate glaucoma risk or they may have common risk factors. Further, antidiabetic medications also exhibited neuroprotective properties in several studies.SummaryGlaucoma is one of the complications significantly influenced by diabetes-induced metabolic changes in the body. Though the preci...
Source: Current Ophthalmology Reports - September 21, 2023 Category: Opthalmology Source Type: research

Glaucoma: A Hidden Threat to Vision Health Rising Swiftly Glaucoma: A Hidden Threat to Vision Health Rising Swiftly
"Late in the disease, people may notice they ' re tripping over the curb, or walking into things they didn ' t see. It really is only in very advanced disease that people notice there ' s anything wrong."WebMD Health News
Source: Medscape Medical News Headlines - September 20, 2023 Category: Consumer Health News Tags: Ophthalmology News Source Type: news

Glaucoma: A Hidden Threat to Vision Health Rising Swiftly
It's predicted that by 2050, the number of people with glaucoma will surge by more than 200%, highlighting an urgent need for heightened awareness, early detection, and advanced treatment strategies.
Source: WebMD Health - September 20, 2023 Category: Consumer Health News Source Type: news

Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma
Mol Aspects Med. 2023 Sep 18;94:101214. doi: 10.1016/j.mam.2023.101214. Online ahead of print.ABSTRACTPseudoexfoliation is a complex, progressive, and systemic age-related disorder. The early stage of deposition of extracellular fibrillar material on ocular and extraocular tissues is termed as pseudoexfoliation syndrome (PEXS). The severe advanced stage is known as pseudoexfoliation glaucoma (PEXG), which involves increased intraocular pressure and optic nerve damage. Through genome-wide association and candidate gene studies, PEX has been associated with numerous genetic risk variants in various gene loci. However, the ge...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Ramani Shyam Kapuganti Debasmita Pankaj Alone Source Type: research