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Condition: Age-Related Macular Degeneration (AMD)

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Total 629 results found since Jan 2013.

Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research

Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research

Associations between vision impairment and vision-related interventions on crash risk and driving cessation: systematic review and meta-analysis
Conclusion Impaired vision identified through a variety of measures is associated with both increased MVC involvement and cessation. Cataract surgery can reduce MVC risk. Despite literature being highly heterogeneous, this review shows that detection of vision problems and appropriate treatment are critical to road safety. PROSPERO registration number CRD42020172153.
Source: BMJ Open - August 11, 2023 Category: General Medicine Authors: Nguyen, H., Di Tanna, G. L., Coxon, K., Brown, J., Ren, K., Ramke, J., Burton, M. J., Gordon, I., Zhang, J. H., Furtado, J., Mdala, S., Kitema, G. F., Keay, L. Tags: Open access, Ophthalmology Source Type: research

Retro-mode: a newer insight into dry age-related macular degeneration (AMD)
AbstractThe purpose of this study is to study the role of retro-mode (RM) in early detection and to compare it with other preexisting available modalities on multimodal imaging system in dry AMD. A prospective observational cross-sectional study was done between November 2020 and October 2021 which included 409 eyes of 207 patients. For study purpose, eyes were divided into 3 groups according to the size and number of the drusen, viz, group 1: No AMD, group 2: early AMD and group 3: intermediate AMD which was further divided into 2 subgroups, viz, subgroup A: eyes with drusen size 63 –125 μm and subgroup B: eyes with dr...
Source: Lasers in Medical Science - August 8, 2023 Category: Laser Surgery Source Type: research

NAD < sup > + < /sup > metabolism and eye diseases: current status and future directions
Mol Biol Rep. 2023 Aug 4. doi: 10.1007/s11033-023-08692-y. Online ahead of print.ABSTRACTCurrently, there are no truly effective treatments for a variety of eye diseases, such as glaucoma, age-related macular degeneration (AMD), and inherited retinal degenerations (IRDs). These conditions have a significant impact on patients' quality of life and can be a burden on society. However, these diseases share a common pathological process of NAD+ metabolism disorders. They are either associated with genetically induced primary NAD+ synthase deficiency, decreased NAD+ levels due to aging, or enhanced NAD+ consuming enzyme activit...
Source: Molecular Biology Reports - August 4, 2023 Category: Molecular Biology Authors: Siyuan Liu Wenfang Zhang Source Type: research

Shedding light on eye disease in obesity: A review
SummaryObesity is known to be associated with numerous ocular manifestations, including but not limited to, diabetic retinopathy (DR), age-related macular degeneration (AMD), cataracts, glaucoma, and dry eye disease. This review aims to provide an overview of the ophthalmological findings in obesity. A literature search was conducted using PubMed and Cochrane databases for studies describing randomized clinical trials, meta-analyses, systematic reviews, and observational studies published from 1 January 2017 to 1 April 2023. The search terms used included relevant keywords such as ‘obesity’, ‘body mass index’, ‘w...
Source: Clinical Obesity - August 3, 2023 Category: Eating Disorders & Weight Management Authors: Shravika Lam, Jennifer Lindsey, Barbara Gisella Carranza Leon, Sahar Takkouche Tags: REVIEW Source Type: research

The effect of baseline intraocular pressure and anterior segment parameters on intraocular pressure after intravitreal bevacizumab injection
CONCLUSION: Pre-injection ACD and IOP values may be predictive of higher post-injection IOP in phakic patients. Preoperative assessment of these parameters could be beneficial in patients at risk of glaucoma.PMID:37531133 | DOI:10.1080/15569527.2023.2243505
Source: Cutaneous and Ocular Toxicology - August 2, 2023 Category: Toxicology Authors: Zeynep Özer Özcan Gizem G ürbostan Soysal Nesime Setge T ıskaoğlu Mustafa Berhuni Source Type: research