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Condition: Blindness

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Total 2323 results found since Jan 2013.

Glaucoma in rural China (the Rural Epidemiology for Glaucoma in China (REG-China)): a national cross-sectional study
Conclusions Rural populations have a high prevalence of glaucoma, which should be included in chronic disease management programmes in China for long-term care.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Liu, Y., Yao, B., Chen, X., Yang, X., Liu, Y., Xie, Z., Chen, X., Yuan, Z., Wang, X., Hu, D., Ma, X., Gao, W., Wang, R., Yang, Y., Chen, S., Zhang, J., Song, Z., Wang, J., Wang, J., Pei, J., Wang, W., Wang, M., Gao, J., Zhang, H., Tan, L., Du, W., Pan, X. Tags: Original articles - Clinical science Source Type: research

Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research

Deep Learning Estimation of 10-2 Visual Field Map Based on Macular Optical Coherence Tomography Angiography Measurements
Glaucoma is a progressive disease associated with characteristic structural changes to the eye and loss of visual function.1 Early diagnosis and monitoring of disease progression are crucial to prevent significant loss of vision and blindness.1,2
Source: American Journal of Ophthalmology - September 19, 2023 Category: Opthalmology Authors: Golnoush Mahmoudinezhad, Sasan Moghimi, Jiacheng Cheng, Liyang Ru, Dongchen Yang, Kushagra Agrawal, Rajeev Dixit, Siavash Beheshtaein, Kelvin H. Du, Kareem Latif, Gopikasree Gunasegaran, Eleonora Micheletti, Takashi Nishida, Alireza Kamalipour, Evan Walke Source Type: research

Genes, Vol. 14, Pages 1809: Factors Associated with Large Cup-to-Disc Ratio and Blindness in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study
Conclusions: These findings underscore the importance of close monitoring of intraocular pressure and visual function in African ancestry POAG patients, particularly those with LCDR, to preserve visual function.
Source: Genes - September 16, 2023 Category: Genetics & Stem Cells Authors: Anusha Mamidipaka Isabel Di Rosa Roy Lee Yan Zhu Yineng Chen Rebecca Salowe Victoria Addis Prithvi Sankar Ebenezer Daniel Gui-Shuang Ying Joan M. O ’Brien Tags: Article Source Type: research

Older people may have common eye condition that causes blindness without realising - study
In new research, half of those diagnosed with glaucoma were unaware of having it.
Source: Daily Express - Health - September 8, 2023 Category: Consumer Health News Source Type: news

Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research

Secondary glaucoma: Toward interventions based on molecular underpinnings
This article is categorized under: Neurological Diseases> Molecular and Cellular Physiology
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - September 6, 2023 Category: Biomedical Science Authors: Anna Mueller, Isabel Lam, Krishna Kishor, Richard K. Lee, Sanjoy Bhattacharya Tags: Advanced Review Source Type: research

An Overview of Current Glaucomatous Trabecular Meshwork Models
CONCLUSION: This review provides an overview of the existing alternative models for studying TM and their potential for advancing research on the pathophysiology of open-angle glaucoma and developing new therapeutic strategies.PMID:37661784 | DOI:10.1080/02713683.2023.2253378
Source: Current Eye Research - September 4, 2023 Category: Opthalmology Authors: Juliette Buffault Fran çoise Brignole-Baudouin Antoine Labb é Christophe Baudouin Source Type: research

Glaucoma Following Cataract Surgery in Children —Finally, a Clue
Childhood cataract is among the more common treatable causes of childhood visual disability and blindness, representing some 10% to 15% of children enrolled globally in schools for blind individuals. Congenital cataracts are genetically heterogeneous with 234 entries on Online Mendelian Inheritance in Man using the search terms congenital cataract. They may be isolated, associated with other ocular anomalies such as microphthalmia or sclerocornea, or be a part of systemic disorders such as trisomy 21 or Lowe syndrome. Some are associated with metabolic conditions such as galactosemia or cerebrotendinous xanthomatosis that ...
Source: JAMA Ophthalmology - September 1, 2023 Category: Opthalmology Source Type: research

Machine learning –couched treatment algorithms tailored to individualized profile of patients with primary anterior chamber angle closure predisposed to the glaucomatous optic neuropathy
AbstractBackgroundPrimary angle closure glaucoma (PACG) is still one of the leading causes of irreversible blindness, with a trend towards an increase in the number of patients to 32.04 million by 2040, an increase of 58.4% compared with 2013. Health risk assessment based on multi-level diagnostics and machine learning –couched treatment algorithms tailored to individualized profile of patients with primary anterior chamber angle closure are considered essential tools to reverse the trend and protect vulnerable subpopulations against health-to-disease progression.AimTo develop a methodology for personalized choice of an ...
Source: EPMA Journal - August 17, 2023 Category: International Medicine & Public Health Source Type: research

The correlation between primary open-angle glaucoma (POAG) and gut microbiota: a pilot study towards predictive, preventive, and personalized medicine
ConclusionThis bioinformatic study elucidates NFKB1, IL18, KITLG, TLR9, FKBP2, and HDAC4 as hub genes for POAG and GM regulation. Immune response modulated by macrophages plays an important role in POAG and may be potential targets for future predictive, preventive, and personalized diagnosis and treatment.
Source: EPMA Journal - August 11, 2023 Category: International Medicine & Public Health Source Type: research