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Drug: Latanoprost

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Total 416 results found since Jan 2013.

Comparison of In Vitro Corneal Permeation and In Vivo Ocular Bioavailability in Rabbits of Three Marketed Latanoprost Formulations
ConclusionBAK did not influence the corneal penetration of latanoprost inin  vitro andin  vivo studies. The formulation containing a non-ionic surfactant resulted in lower and slower ocular penetration compared with preserved or PF SF formulations. This raises questions about the relevance of BAK and some surfactants in enhancing corneal penetration of ocular formulations.
Source: European Journal of Drug Metabolism and Pharmacokinetics - September 8, 2023 Category: Drugs & Pharmacology Source Type: research

COMfort Eye Trial (COMET) results - a non-inferiority, randomized, investigator-masked, two-parallel group, phase III clinical trial, to evaluate the efficacy and safety of a preservative free formulation of latanoprost versus a reference drug (Xalatan ®) in patients with primary open-angle glaucoma (POAG) or ocular hypertension (OHT)
CONCLUSIONS: YSLT eye drops demonstrated non-inferiority to latanoprost in reducing IOP. Both products were well tolerated without serious TEAEs reported.PMID:37674345 | DOI:10.1080/14740338.2023.2252341
Source: Expert Opinion on Drug Safety - September 7, 2023 Category: Drugs & Pharmacology Authors: Stylianos Kandarakis Alexandros P Papadopoulos Georgios Roussopoulos Eustathios Georgopoulos Youngsik Chung Leonidas Doumazos Areum Baek Nefeli Ioanna Paizi Hyunik Shin Pantelis A Papadopoulos Source Type: research

Persistence of the carteolol hydrochloride/latanoprost fixed-combination ophthalmic solution, compared with the other β-blocker/prostanoid FP receptor agonist fixed-combination ophthalmic solutions
ConclusionThe study results suggest that persistence rates vary depending on the BB/FP and CAR/LAT appears to be more persistent than other BB/FP.
Source: Japanese Journal of Ophthalmology - August 19, 2023 Category: Opthalmology Source Type: research

Study profile: the Genetics of Glaucoma Study
Purpose Glaucoma, a major cause of irreversible blindness, is a highly heritable human disease. Currently, the majority of the risk genes for glaucoma are unknown. We established the Genetics of Glaucoma Study (GOGS) to identify disease genes and improve genetic prediction of glaucoma risk and response to treatment. Participants More than 5700 participants with glaucoma or a family history of glaucoma were recruited through a media campaign and the Australian Government healthcare service provider, Services Australia, making GOGS one of the largest genetic studies of glaucoma globally. The mean age of the participants was...
Source: BMJ Open - August 3, 2023 Category: General Medicine Authors: Gharahkhani, P., He, W., Diaz Torres, S., Wu, Y., Ingold, N., Yu, R., Seviiri, M., Ong, J.-S., Law, M. H., Craig, J. E., Mackey, D. A., Hewitt, A. W., MacGregor, S. Tags: Open access, Ophthalmology Source Type: research

New trends towards glaucoma treatment: Topical osmoprotective microemulsions loaded with latanoprost
Ocul Surf. 2023 Jun 7:S1542-0124(23)00055-1. doi: 10.1016/j.jtos.2023.05.013. Online ahead of print.ABSTRACTThe chronic use of hypotensive agents eventually leads to ocular surface damage and poor patient compliance during glaucoma management. Thus, new sustained drug delivery systems are needed. This work aimed to develop osmoprotective latanoprost-loaded microemulsion formulations as new potential glaucoma treatments with ocular surface protective properties. The microemulsions were characterized and latanoprost encapsulation efficacy determined. In-vitro tolerance, osmoprotective efficacy, cell internalization as well a...
Source: The Ocular Surface - June 9, 2023 Category: Opthalmology Authors: J J L ópez-Cano M A Gonz ález-Cela-Casamayor V Andr és-Guerrero M Vicario-de-la-Torre J M Ben ítez-Del-Castillo R Herrero-Vanrell I T Molina-Mart ínez Source Type: research

Effects of Ripasudil, a Rho-Kinase Inhibitor, on Scar Formation in a Mouse Model of Filtration Surgery
CONCLUSIONS: These results suggest that ripasudil, ROCK inhibitor may inhibit excessive fibrosis after glaucoma filtering surgery vis inhibition the transdifferentiation of tenon fibroblast into myofibroblast and may have a potential effect as anti-scarring for glaucoma filtration surgery.PMID:37216470 | DOI:10.1080/02713683.2023.2217367
Source: Current Eye Research - May 22, 2023 Category: Opthalmology Authors: Ji-Ae Ko Kaori Komatsu Akira Minamoto Satomi Kondo Hideaki Okumichi Kazuyuki Hirooka Yoshiaki Kiuchi Source Type: research