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Infectious Disease: Gastroenteritis
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Total 18 results found since Jan 2013.
Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research
A systematic approach to reduce intraocular pressure for the treatment of glaucoma
AbstractGlaucoma is the leading cause of irreversible blindness due to increased intraocular pressure (IOP) in the eye. We have developed a novel treatment option for glaucoma based on a real-time IOP-dependent nitric oxide synthase (NOS) and packed in a therapeutic contact lens to reduce the IOP. First, 1.6 nmole nitric oxide was produced from the genetic chassis, which was optimized for isopropyl β-d-1-thiogalactopyranoside (IPTG) induction in a T7 expression system. For biosafety concerns to human being, thecsgAD genes responsible for curli biofilm formation inEscherichia coli were co-expressed with NOS in the designat...
Source: Biotechnology Progress - July 19, 2022 Category: Biotechnology Authors: Yi ‐Lun Huang,
Yu‐Ling Hsu,
Ya‐Chu Yu,
Hong‐Yan Huang,
Ren‐Hao Tsai,
Yao‐Tien Cheng,
Yi‐Ling Chou,
Sheng‐Yan Sun,
Li‐An Wang,
Jia‐Yi Lin,
Chao‐Chung Chen,
Jia‐Horung Hung,
I‐Son Ng Tags: RESEARCH ARTICLE Source Type: research
Calcium dysregulation potentiates wild-type myocilin misfolding: implications for glaucoma pathogenesis
This study explores the effect of calcium depletion on myocilin olfactomedin domain folding.PMID:35831671 | DOI:10.1007/s00775-022-01946-3
Source: Journal of Biological Inorganic Chemistry : JBIC - July 13, 2022 Category: Chemistry Authors: Emily G Saccuzzo Mackenzie D Martin Kamisha R Hill Minh Thu Ma Yemo Ku Raquel L Lieberman Source Type: research
A systematic approach to reduce intraocular pressure (IOP) for the treatment of glaucoma
This article is protected by copyright. All rights reserved.
Source: Biotechnology Progress - July 8, 2022 Category: Biotechnology Authors: Yi ‐Lun Huang,
Yu‐Ling Hsu,
Ya‐Chu Yu,
Hong‐Yan Huang,
Ren‐Hao Tsai,
Yao‐Tien Cheng,
Yi‐Ling Chou,
Sheng‐Yan Sun,
Li‐An Wang,
Jia‐Yi Lin,
Chao‐Chung Chen,
Jia‐Horung Hung,
I‐Son Ng Tags: RESEARCH ARTICLE Source Type: research
Synthesis, structural elucidation, DNA binding, cleavage, AChE and BuChE cholinesterase efficiencies of metal complexes with 1,10-phenanthroline scaffold
Nucleosides Nucleotides Nucleic Acids. 2022 Jan 26:1-29. doi: 10.1080/15257770.2021.2011915. Online ahead of print.ABSTRACTA series of metal complexes containing a 1,10-phenanthroline scaffold [ML] (L-1,10-Phenanthroline derivative comprises conjugated aromatic core and electron withdrawing -NO2 group); M = Cu(II), Zn(II), Co(II), and Zn(II) ions were designed and synthesized to obtain effective anti-cholinesterase efficiencies of metal chelates. Analytical and spectroscopic studies were used to determine the structural features. An octahedral structure with moderate distortion was attributed to the above metal chelates ba...
Source: Nucleosides, Nucleotides and Nucleic Acids - January 26, 2022 Category: Biochemistry Authors: E H Edinsha Gladis K Nagashri A Krishnendu Source Type: research
Mutations in < i > SPATA13/ASEF2 < /i > cause primary angle closure glaucoma
by Naushin H. Waseem, Sancy Low, Amna Z. Shah, Deepa Avisetti, Pia Ostergaard, Michael Simpson, Katarzyna A. Niemiec, Belen Martin-Martin, Hebah Aldehlawi, Saima Usman, Pak Sang Lee, Anthony P. Khawaja, Jonathan B. Ruddle, Ameet Shah, Ege Sackey, Alexander Day, Yuzhen Jiang, Geoff Swinfield, Ananth Viswanathan, Giovanna Alfano, Christina Chakarova, Heather J. Cordell, David F. Garway-Heath, Peng T. Khaw, Shomi S. Bhattacharya, Ahmad Waseem, Paul J. Foster
Current estimates suggest 50% of glaucoma blindness worldwide is caused by primary angle-closure glaucoma (PACG) but the causative gene is not known. We used genetic lin...
Source: PLoS Genetics - April 26, 2020 Category: Genetics & Stem Cells Authors: Naushin H. Waseem Source Type: research
Gut microbiota compositional profile and serum metabolic phenotype in patients with primary open-angle glaucoma.
Abstract
The gut microbiota (GM) and its influence on host metabolism are considered to be an environmental factor that contributes to the progression of many immune and neurodegenerative diseases. However, the features of the GM and serum metabolites in Primary open-angle glaucoma (POAG) patients have not been clearly elucidated. The purpose of this research is to explore the gut microbial composition and serum metabolic phenotype in POAG patients. 16S rRNA V4 genes of bacteria from the fecal samples of 30 POAG patients and 30 healthy subjects were sequenced by the Illumina MiSeq platform and then analyzed by QII...
Source: Experimental Eye Research - January 5, 2020 Category: Opthalmology Authors: Gong H, Zhang S, Li Q, Zuo C, Gao X, Zheng B, Lin M Tags: Exp Eye Res Source Type: research
Plant-Derived Alkaloids: The Promising Disease-Modifying Agents for Inflammatory Bowel Disease
Conclusion
This paper summarizes the current findings regarding the anti-colitis activity of plant-derived alkaloids and shows how these alkaloids exhibit significant and beneficial effects in alleviating colonic inflammation. These natural alkaloids are not only promising agents for IBD treatment but are also components for developing new wonder drugs. However, the underlying molecular mechanisms or toxicological evaluation of most plant-derived alkaloids still require much scientific research, and their actual efficacies for IBD patients have not been verified well in field research. Thus, further clinical trials to elu...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research
Intrinsic thermodynamics of high affinity inhibitor binding to recombinant human carbonic anhydrase IV.
Abstract
Membrane-associated carbonic anhydrase (CA) isoform IV participates in carbon metabolism and pH homeostasis and is implicated in the development of eye diseases such as retinitis pigmentosa and glaucoma. A series of substituted benzenesulfonamides were designed and their binding affinity to CA IV was determined by fluorescent thermal shift assay and isothermal titration calorimetry (ITC). Compound [(4-chloro-2-phenylsulfanyl-5-sulfamoyl-benzoyl)amino]propyl acetate (19) bound CA IV with the K d of 1.0 nM and exhibited significant selectivity over the remaining 11 human CA isoforms. The compound could be ...
Source: European Biophysics Journal : EBJ - October 3, 2017 Category: Physics Authors: Mickevičiūtė A, Timm DD, Gedgaudas M, Linkuvienė V, Chen Z, Waheed A, Michailovienė V, Zubrienė A, Smirnov A, Čapkauskaitė E, Baranauskienė L, Jachno J, Revuckienė J, Manakova E, Gražulis S, Matulienė J, Di Cera E, Sly WS, Matulis D Tags: Eur Biophys J Source Type: research
