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Infectious Disease: Tuberculosis

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Total 29 results found since Jan 2013.

The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies
Cell Mol Life Sci. 2023 Aug 4;80(8):239. doi: 10.1007/s00018-023-04890-w.ABSTRACTRetinal ganglion cells (RGCs) are essential for vision perception. In glaucoma and other optic neuropathies, RGCs and their optic axons undergo degenerative change and cell death; this can result in irreversible vision loss. Here we developed a rapid protocol for directly inducing RGC differentiation from human induced pluripotent stem cells (hiPSCs) by the overexpression of ATOH7, BRN3B, and SOX4. The hiPSC-derived RGC-like cells (iRGCs) show robust expression of various RGC-specific markers by whole transcriptome profiling. A functional asse...
Source: Cellular and Molecular Life Sciences : CMLS - August 4, 2023 Category: Cytology Authors: Roxanne Hsiang-Chi Liou Shih-Wei Chen Hui-Chen Cheng Pei-Chun Wu Yu-Fen Chang An-Guor Wang Ming-Ji Fann Yu-Hui Wong Source Type: research

High rate of conversion from ocular hypertension to glaucoma in subjects with uveitis
Conclusion Rapid progression was observed from ocular hypertension to uveitic glaucoma. Uveitic glaucoma is aggressive, with high likelihood of requiring surgical management and high risk of central vision loss. Close collaboration between uveitis and glaucoma specialists is required to maximise outcomes for these patients.
Source: British Journal of Ophthalmology - October 20, 2022 Category: Opthalmology Authors: Ma, T., Sims, J. L., Bennett, S., Chew, S., Niederer, R. L. Tags: Original articles - Clinical science Source Type: research

Visual outcome and prognostic factors in cataract surgery in ocular tuberculosis
Conclusion: The visual outcome after cataract surgery in OTB was satisfactory as significant number of patients achieved a good final visual acuity.
Source: Indian Journal of Ophthalmology - August 19, 2020 Category: Opthalmology Authors: Samrat Chatterjee Deepshikha Agrawal Swapnil M Parchand Anupam Sahu Source Type: research

Long-term outcomes of cataract surgery in children with uveitis
Conclusion: Even though number of secondary procedures was more in pseudophakic group, meticulous choice of surgical technique and adequate immunosuppression lead to a modest gain of visual acuity in children undergoing IOL implantation in uveitis. However, scrupulous case selection and aggressive control of pre- and postoperative intraocular inflammation are the key factors in the postoperative success of these patients.
Source: Indian Journal of Ophthalmology - March 21, 2019 Category: Opthalmology Authors: Sonam Yangzes Natasha Gautam Seth Ramandeep Singh Parul Chawla Gupta Jitender Jinagal Surinder Singh Pandav Vishali Gupta Amod Gupta Jagat Ram Source Type: research

Ascites, peritoneal implants and elevated Ca-125
A 75-year-old Ethiopian-born woman (emigrated aged 48 years) was admitted with acute recurrent vomiting and mild abdominal pain. She had long-standing orally treated diabetes, hypertension and glaucoma. Examination, ECG, chest and abdominal X-rays were unremarkable save for tachycardia 130/min. Hb was 10.2 g/dl, blood urea nitrogen (BUN) 18 mg/dl, creatinine 1.6 mg/dl (previously 1.0), C-reactive protein (CRP) 30.4 mg/dl, normal amylase and liver enzymes. Her ‘gastroenteritis’ improved with fluids and she was quickly discharged, only to be readmitted within 6 days with anorexia and diffuse abdominal pain. Examination n...
Source: QJM - March 14, 2019 Category: Internal Medicine Source Type: research

Acute Angle Closure Secondary to Tubercular Choroidal Granuloma
We report a patient who presented to the medical emergency with headache and vomiting and was subsequently found to have acute angle closure in 1 eye secondary to a tubercular choroidal granuloma. This presentation of ocular tuberculosis has not been reported previously.
Source: Journal of Glaucoma - December 1, 2017 Category: Opthalmology Tags: Online Articles: Case Report/Small Case Series Source Type: research

Clinical Outcomes of Adjunctive Sustained-Release Intravitreal Dexamethasone Implants in Tuberculosis-Associated Multifocal Serpigenoid Choroiditis.
CONCLUSIONS: Sustained-release intravitreal dexamethasone is a safe and efficacious adjunctive anti-inflammatory therapy for TB-associated MSC patients with contraindication for systemic corticosteroids or requiring supplemental anti-inflammatory therapy. PMID: 29020496 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - October 13, 2017 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Patterns of intermediate uveitis in children presenting at a tertiary eye care center in South India
Conclusion: Median time of development of complications is about 3 years based on our study. Intermediate uveitis of childhood might exhibit a self-limiting course after several years. Visual recovery is good in the majority, and visual loss is limited despite the high rate of ocular complications.
Source: Middle East African Journal of Ophthalmology - September 7, 2017 Category: Opthalmology Authors: Radha Annamalai Jyotirmay Biswas Source Type: research

What Causes Uveitis?
Discussion Inflammation of the middle layer of the eye, or uvea, is termed uveitis. Uveitis can be divided into anterior, intermediate or posterior uveitis by involving the anterior (iris and ciliary body), intermediate (vitreous) or posterior (choroid and usually retina) compartments. Panuveitis involves all 3 compartments. Duration can also be used to classify uveitis. Acute is 6 weeks and > 3 months is chronic persistent uveitis. Episodic periods of inactivity and reactivity that last more than 3 months are called recurrent uveitis. A third way to characterize uveitis is if it is granulomatous or not. Uveitis increas...
Source: PediatricEducation.org - April 3, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Visual Morbidity and Ocular Complications in Presumed Intraocular Tuberculosis: An Analysis of 354 Cases from a Non-Endemic Population.
CONCLUSION: Intraocular TB can be associated with significant ocular morbidity. Early recognition, treatment, and regular follow-up of this complex disease may help to reduce visual morbidity and ocular complications. PMID: 28318349 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - March 21, 2017 Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research

Clinical Features and Prognostic Factors in Presumed Ocular Tuberculosis.
CONCLUSIONS: The diagnosis of ocular TB can be difficult due to the lack of extraocular manifestations and the broad spectrum of ocular features. A longer duration of symptoms at diagnosis was associated with poorer visual outcomes and cataracts. Therefore, efforts should be made to avoid a delay in the diagnosis of ocular TB and to identify prognostic factors for visual outcomes and complications. PMID: 28157425 [PubMed - as supplied by publisher]
Source: Current Eye Research - February 2, 2017 Category: Opthalmology Authors: Urzua CA, Lantigua Y, Abuauad S, Liberman P, Berger O, Sabat P, Velasquez V, Castiglione E, Calonge M Tags: Curr Eye Res Source Type: research