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Total 127 results found since Jan 2013.

Secondary glaucoma: Toward interventions based on molecular underpinnings
This article is categorized under: Neurological Diseases> Molecular and Cellular Physiology
Source: Wiley Interdisciplinary Reviews: Systems Biology and Medicine - September 6, 2023 Category: Biomedical Science Authors: Anna Mueller, Isabel Lam, Krishna Kishor, Richard K. Lee, Sanjoy Bhattacharya Tags: Advanced Review Source Type: research

The potential for mitochondrial therapeutics in the treatment of primary open-angle glaucoma: a review
Glaucoma, an age-related neurodegenerative disease, is characterized by the death of retinal ganglion cells (RGCs) and the corresponding loss of visual fields. This disease is the leading cause of irreversible blindness worldwide, making early diagnosis and effective treatment paramount. The pathophysiology of primary open-angle glaucoma (POAG), the most common form of the disease, remains poorly understood. Current available treatments, which target elevated intraocular pressure (IOP), are not effective at slowing disease progression in approximately 30% of patients. There is a great need to identify and study treatment o...
Source: Frontiers in Physiology - August 2, 2023 Category: Physiology Source Type: research

Retinoprotective compounds, current efficacy, and future prospective
Neural Regen Res. 2023 Dec;18(12):2619-2622. doi: 10.4103/1673-5374.373662.ABSTRACTRetinal dysfunction is the most common cause of vision loss in several retinal disorders. It has been estimated a great increase in these pathologies that are becoming more globally widespread and numerous over time, also supported by the life expectancy increment. Among different types of retinopathies, we can account some that share causes, symptoms, and treatment including diabetic retinopathy, age-related macular degeneration, glaucoma, and retinitis pigmentosa. Molecular changes, environmental factors, and genetic predisposition might b...
Source: Cell Research - July 14, 2023 Category: Cytology Authors: Rachele Marino Rebecca Sappington Marco Feligioni Source Type: research

Preserving Retinal Structure and Function with the Novel Nitroxide Antioxidant, DCTEIO
This study investigates the efficacy of DCTEIO (5,6-dicarboxy-1,1,3,3-tetraethyllisoindolin-2-yloxyl), a stable, kinetically-persistent, nitroxide-based antioxidant, as a retinal neuroprotectant. The preservation of retinal function following an acute ischaemic/reperfusion (I/R) insult in the presence of DCTEIO was quantified by electroretinography (ERG). Inflammatory responses in retinal glia were analysed by GFAP and IBA-1 immunohistochemistry, and retinal integrity assessed by histology. A nitroxide probe combined with flow cytometry provided a rapid technique to assess oxidative stress and the mitigation offered by ant...
Source: Neurochemical Research - July 14, 2023 Category: Neuroscience Authors: Cassie L Rayner Steven E Bottle Alexander P Martyn Nigel L Barnett Source Type: research

Natural products: protective effects against ischemia-induced retinal injury
This article reviews the neuroprotective mechanisms of natural compounds involve treating ischemic retinal injury. These natural compounds may serve as treatments for ischemia-induced retinal diseases.
Source: Frontiers in Pharmacology - April 26, 2023 Category: Drugs & Pharmacology Source Type: research

Molecules, Vol. 28, Pages 1739: Comprehensive Metabolite Profiling of Berdav Propolis Using LC-MS/MS: Determination of Antioxidant, Anticholinergic, Antiglaucoma, and Antidiabetic Effects
In this study, the chemical composition and antioxidant activities of propolis were investigated; ABTS•+, DPPH• and DMPD•+ were prepared using radical scavenging antioxidant methods. The phenolic and flavonoid contents of propolis were 53 mg of gallic acid equivalent (GAE)/g and 170.164 mg of quercetin equivalent (QE)/g, respectively. The ferric ion (Fe3+) reduction, CUPRAC and FRAP reduction capacities were also studied. The antioxidant and reducing capacities of propolis were compared with those of butylated hydroxyanisole (BHA), butylated hydroxytoluene (BHT), α-tocop...
Source: Molecules - February 11, 2023 Category: Chemistry Authors: Hasan Karagecili Mustafa Abdullah Y ılmaz Adem Ert ürk Hatice Kiziltas Leyla G üven Saleh H. Alwasel İlhami Gulcin Tags: Article Source Type: research

Review of Evidence for the Usage of Antioxidants for Eye Aging
Biomed Res Int. 2022 Oct 3;2022:5810373. doi: 10.1155/2022/5810373. eCollection 2022.ABSTRACTOxidative stress is one of the common factors leading to age-related eye diseases in older adults. Factors such as high oxygen consumption, high concentration of polyunsaturated fatty acids, and cumulative exposure to high-energy visible light in the eyes, lead to excessive generation of reactive oxygen species, hence triggering apoptosis of ocular cells and giving rise to ophthalmic diseases. Dietary supplements such as carotenoids, anthocyanins, and vitamins have antioxidant properties which may be of benefit in retaining better ...
Source: Biomed Res - October 13, 2022 Category: Research Authors: Priscilla Peixi Choo Pui Juan Woi Mae-Lynn Catherine Bastion Rokiah Omar Mushawiahti Mustapha Norshamsiah Md Din Source Type: research

Neuroprotective Properties of Chlorogenic Acid and 4,5-Caffeoylquinic Acid from Brazilian arnica (Lychnophora ericoides) after Acute Retinal Ischemia
In this study, we report the neuroprotective effects of CGA and 4,5-di-O-[E]-caffeoylquinic (CQA) acid, isolated from Lychnophora plants, in a rodent glaucoma model. Wistar rats were administered intravitreally with 10 µg CGA or CGA, and then subjected to acute retinal ischemia (ISC) by increasing intraocular pressure (IPO) for 45 minutes followed (or not) by 15 minutes of reperfusion (I/R). Qualitative and quantitative analyses of neurodegeneration were performed using hematoxylin-eosin or Fluoro-Jade C staining protocols. All retinas submitted to ISC or I/R exhibited matrix disorganization, pyknotic ...
Source: Planta Medica - October 11, 2022 Category: Drugs & Pharmacology Authors: Liberato, Jos é Luiz Rosa, Marcela Nunes Miranda, Matheus C. Romeiro Lopes, Jo ão Luís Callegari Lopes, Norberto Peporine Gobbo-Neto, Leonardo Fontana, Andreia C. K. dos Santos, Wagner Ferreira Tags: Original Papers Source Type: research

Molecules, Vol. 27, Pages 5902: Antioxidant, Antidiabetic, Anticholinergic, and Antiglaucoma Effects of Magnofluorine
hami Gulcin Magnofluorine, a secondary metabolite commonly found in various plants, has pharmacological potential; however, its antioxidant and enzyme inhibition effects have not been investigated. We investigated the antioxidant potential of Magnofluorine using bioanalytical assays with 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS•+), N,N-dimethyl-p-phenylenediamine dihydrochloride (DMPD•+), and 1,1-diphenyl-2-picrylhydrazyl (DPPH•) scavenging abilities and K3[Fe(CN)6] and Cu2+ reduction abilities. Further, we compared the effects of Magnofluorine and butylated hyd...
Source: Molecules - September 11, 2022 Category: Chemistry Authors: Lokman Durmaz Hatice Kiziltas Leyla Guven Hasan Karagecili Saleh Alwasel İlhami Gulcin Tags: Article Source Type: research