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Total 3660 results found since Jan 2013.

Neurofilament light chain: a new marker for neuronal decay in the anterior chamber fluid of patients with glaucoma
Conclusion NfL levels in anterior chamber fluid are elevated in patients with glaucoma and correlate with intraocular pressure and retinal nerve fibre layer thickness. The presented data strongly support anterior chamber fluid NfL as a new marker for glaucoma.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Woltsche, N., Valentin, K., Hoeflechner, L., Guttmann, A., Horwath-Winter, J., Schneider, M. R., Ivastinovic, D., Lindner, M., Schmetterer, L., Singh, N., Riedl, R., Buchmann, A., Khalil, M., Lindner, E. Tags: Original articles - Clinical science Source Type: research

Hand grip strength and ocular associations: the Ural Eye and Medical Study
Conclusions and relevance In addition to parameters such as lower physical activity, higher depression score and worse general health status, a reduced HGS is associated with visual impairment, shorter axial length, lower intraocular pressure, thinner peripapillary retinal nerve fibre layer and higher prevalence of diabetic retinopathy. HGS dynamometry or a handshake may provide the ophthalmologist additional clinical information about the general health and ocular parameters of the patient.
Source: British Journal of Ophthalmology - September 21, 2023 Category: Opthalmology Authors: Bikbov, M. M., Zainullin, R. M., Gilmanshin, T. R., Iakupova, E. M., Kazakbaeva, G. M., Panda-Jonas, S., Tuliakova, A. M., Fakhretdinova, A. A., Gilemzianova, L. I., Jonas, J. B. Tags: Original articles - Clinical science Source Type: research

Retinal ganglion cell repopulation for vision restoration in optic neuropathy: a roadmap from the RReSTORe Consortium
Retinal ganglion cell (RGC) death in glaucoma and other optic neuropathies results in irreversible vision loss due to the mammalian central nervous system ’s limited regenerative capacity. RGC repopulation is a...
Source: Molecular Neurodegeneration - September 21, 2023 Category: Neurology Authors: Jonathan R. Soucy, Erika A. Aguzzi, Julie Cho, Michael James Gilhooley, Casey Keuthan, Ziming Luo, Aboozar Monavarfeshani, Meher A. Saleem, Xue-Wei Wang, Juilette Wohlschlegel, Petr Baranov, Adriana Di Polo, Brad Fortune, Kimberly K. Gokoffski, Jeffrey L. Tags: Review Source Type: research

Impact of Type 2 Diabetes Mellitus-Related Factors on Glaucoma: a Comprehensive Review
AbstractPurposeTo investigate the contradictory association of glaucoma with type 2 diabetes mellitus (T2DM) and its related factors that have been a springboard for a number of complications including glaucoma. Also, to examine the neuroprotective effects of antidiabetic medications.Recent FindingsRecent studies suggest that T2DM may alleviate glaucoma risk or they may have common risk factors. Further, antidiabetic medications also exhibited neuroprotective properties in several studies.SummaryGlaucoma is one of the complications significantly influenced by diabetes-induced metabolic changes in the body. Though the preci...
Source: Current Ophthalmology Reports - September 21, 2023 Category: Opthalmology Source Type: research

Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Vision Research - September 18, 2023 Category: Opthalmology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research

Systemic immuno-inflammatory index in patients with pseudoexfoliation syndrome and pseudoexfoliative glaucoma
CONCLUSIONS: In PEXS patients, both SII and NLR were significantly higher, albeit in a small group of patients, and SII may be a helpful and supportive parameter for NLR in risk estimation in these patients. There was a statistically significant difference only in NLR in patients with PEXG when compared with the control group. However, these results need to be supported by future longitudinal and larger studies to identify any possible link between hematological inflammatory markers and pseudoexfoliation.PMID:37720205 | PMC:PMC10504835 | DOI:10.1177/25158414231197072
Source: Adv Data - September 18, 2023 Category: Epidemiology Authors: Nejla Tukenmez Dikmen Yasemin Un Source Type: research

Genes, Vol. 14, Pages 1809: Factors Associated with Large Cup-to-Disc Ratio and Blindness in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study
Conclusions: These findings underscore the importance of close monitoring of intraocular pressure and visual function in African ancestry POAG patients, particularly those with LCDR, to preserve visual function.
Source: Genes - September 16, 2023 Category: Genetics & Stem Cells Authors: Anusha Mamidipaka Isabel Di Rosa Roy Lee Yan Zhu Yineng Chen Rebecca Salowe Victoria Addis Prithvi Sankar Ebenezer Daniel Gui-Shuang Ying Joan M. O ’Brien Tags: Article Source Type: research

Ocular findings in patients with acquired ATTRv amyloidosis following domino liver transplantation
ConclusionWhile cases of choroidal amyloid angiopathy were observed, serious amyloidosis-related ocular complications such as vitreous opacity or secondary glaucoma did not occur even in the long term after domino liver transplantation.
Source: PLoS One - September 15, 2023 Category: Biomedical Science Authors: Junya Kitahara Source Type: research

Anterior segment complications after dexamethasone implantations:real world data
ConclusionThis study is the first long-term follow-up study in our country evaluating the safety of dexamethasone implant injections in various retinal diseases and presenting the first real world data. Cataract progression and increased IOP were found to be the most common side effects. We observed that the patient ’s diagnosis did not cause a statistically significant change in the observation of side effects. As a result of our findings, close follow-up of IOP after the injection of dexamethasone implants would be appropriate.
Source: International Ophthalmology - September 14, 2023 Category: Opthalmology Source Type: research

Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases
Regen Med. 2023 Sep 13. doi: 10.2217/rme-2023-0089. Online ahead of print.ABSTRACTResearch has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential the...
Source: Regenerative Medicine - September 13, 2023 Category: Genetics & Stem Cells Authors: Wesley Harrisson Bouche Djatche Huimin Zhu Wenlei Ma Yue Li Ziang Li Hong Zhao Zhizhen Liu Hua Qiao Source Type: research