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Total 26176 results found since Jan 2013.

The Evaluation of Retinal Nerve Fiber Layer and Ganglion Cell Complex Thickness in Adult Offspring of Primary Open-angle Glaucoma Patients
Conclusions: In adult offspring of POAG patients, especially in the inferior quadrant, the RNFL and GCC thickness are significantly lower than in subjects without a family history. Prospective, controlled clinical trials with longer follow-up are needed to better understand whether these changes are an early indicator of glaucoma, and the progression of glaucoma disease.
Source: Journal of Glaucoma - September 1, 2020 Category: Opthalmology Tags: Original Studies Source Type: research

The role of clinical examination of the optic nerve head in glaucoma today
Purpose of review The study was undertaken to assess the current importance of clinical examination of the optic nerve head (ONH) in glaucoma management. Recent findings ONH changes in glaucoma are easily assessed with good specificity on examination, whereas imaging has not been able to identify pallor of the neuroretinal rim (NRR), disc hemorrhages, or vascular signs of acquired cupping. Glaucomatous neuropathy in primary open angle glaucoma (POAG) has extensive databases on imaging machines, however, other glaucomas such as primary angle closure glaucoma (PACG), juvenile open angle glaucoma (JOAG), congenital...
Source: Current Opinion in Ophthalmology - February 13, 2021 Category: Opthalmology Tags: GLAUCOMA: Edited by Donald L. Budenz Source Type: research

Advances in medical therapy for glaucoma
Purpose of review To discuss a new class of medication that has recently become available for the treatment of glaucoma; as well as share insights into developments in glaucoma medicine administration which has the potential to revolutionize medical therapy for glaucoma. Recent findings Newly available eye drops, netarsudil 0.02% and latanoprostene bunod 0.024%, are improving aqueous outflow through the conventional outflow tract. Other new developments in medical glaucoma are focused on alternative methods for sustained glaucoma medication delivery. Summary Newer medications may be able to extend the dur...
Source: Current Opinion in Ophthalmology - February 13, 2021 Category: Opthalmology Tags: GLAUCOMA: Edited by Donald L. Budenz Source Type: research

Surgical Management of Pseudoexfoliative Glaucoma: A Review of Current Clinical Considerations and Surgical Outcomes
Conclusion: Specific studies of the surgical management of PEXG remain scarce in the medical literature, and more long-term and comparative studies are warranted to define more robust recommendations.
Source: Journal of Glaucoma - March 1, 2021 Category: Opthalmology Tags: Review Articles Source Type: research

Twelve-Year Incidence of Open-angle Glaucoma: The Thessaloniki Eye Study
Conclusions: The incidence of OAG was similar or higher compared with other White populations. The incidence of glaucoma in those with PEX was higher compared with the incidence of glaucoma in those without PEX.
Source: Journal of Glaucoma - September 1, 2021 Category: Opthalmology Tags: Novel Insights: Original Studies Source Type: research

How glaucoma care changed for the better after the pandemic
Purpose of review The current article reviews enhancements to the delivery of glaucoma care that developed in response to the coronavirus disease 19 (COVID-19) pandemic and are likely to persist beyond its resolution. Recent findings Literature from the review period (2020–2021) includes reports highlighting contributions of the ophthalmology community to global health during the pandemic. Glaucoma practices worldwide have instituted more robust infection control measures to mitigate severe acute respiratory syndrome coronavirus 2 transmission in the outpatient setting, and many of these modifications will end...
Source: Current Opinion in Ophthalmology - February 10, 2022 Category: Opthalmology Tags: GLAUCOMA: Edited by Donald L. Budenz Source Type: research

Glaucoma and biomechanics
Purpose of review Biomechanics is an important aspect of the complex family of diseases known as the glaucomas. Here, we review recent studies of biomechanics in glaucoma. Recent findings Several tissues have direct and/or indirect biomechanical roles in various forms of glaucoma, including the trabecular meshwork, cornea, peripapillary sclera, optic nerve head/sheath, and iris. Multiple mechanosensory mechanisms and signaling pathways continue to be identified in both the trabecular meshwork and optic nerve head. Further, the recent literature describes a variety of approaches for investigating the role of tiss...
Source: Current Opinion in Ophthalmology - February 10, 2022 Category: Opthalmology Tags: GLAUCOMA: Edited by Donald L. Budenz Source Type: research

Twenty-Four-Hour Pattern of Intraocular Pressure in Untreated Patients with Ocular Hypertension Glaucoma
Conclusions. Baseline 24-hour IOP pattern in OHTN patients is similar to that in glaucomatous patients. In contrast to nonconverters, OHTN patients who converted to glaucoma are significantly different from healthy controls.
Source: Investigative Ophthalmology - January 17, 2013 Category: Opthalmology Authors: Grippo, T. M., Liu, J. H. K., Zebardast, N., Arnold, T. B., Moore, G. H., Weinreb, R. N. Tags: Glaucoma Source Type: research

Association between Myopia and Glaucoma in the United States Population Glaucoma
Conclusions. The association between myopia and visual field defects may represent an increased risk of glaucoma among myopes, and the lack of association with self-reported glaucoma may suggest a need for greater glaucoma surveillance in this population.
Source: Investigative Ophthalmology - January 28, 2013 Category: Opthalmology Authors: Qiu, M., Wang, S. Y., Singh, K., Lin, S. C. Tags: Glaucoma Source Type: research

Morphology of Astrocytes in a Glaucomatous Optic Nerve Glaucoma
Conclusions. Confirming results after optic nerve crush, astrocytes in glaucomatous optic nerves had thickened and simplified processes, and reduced spatial coverage. We also found evidence of localized sprouting of new processes in early stages of the disease, before detectable changes in ganglion cell number.
Source: Investigative Ophthalmology - February 1, 2013 Category: Opthalmology Authors: Lye-Barthel, M., Sun, D., Jakobs, T. C. Tags: Glaucoma Source Type: research

Are preservatives necessary to improve efficacy of some glaucoma drops?
Glaucoma is a multifactorial optic neuropathy involving progressive optic nerve damage associated with loss of visual function and often with elevated intraocular pressure (IOP).1 2 It is the second most important cause of world blindness after cataracts. It has been estimated that 79.6 million people will suffer from glaucoma in 2020, and of these, 74% will have open-angle glaucoma.3 Elevated IOP has been recognised as the major risk factor for the development of glaucoma and consistently demonstrated to be associated with its progression.4 Among the treatment goals of glaucoma therapy, IOP control is the mainstay. In est...
Source: British Journal of Ophthalmology - November 8, 2013 Category: Opthalmology Authors: Irkec, M., Bozkurt, B., Mocan, M. C. Tags: Angle, Intraocular pressure, Lens and zonules, Optic nerve, Vision, Neurology, Glaucoma Editorials Source Type: research

A Comparative Effectiveness Analysis of Visual Field Outcomes After Projected Glaucoma Screening Using SD-OCT in African American Communities Glaucoma
Conclusions. Our findings suggest that community SD-OCT screening in an African American population will minimize glaucoma-related visual morbidity. Ideally, strategies to maximize treatment efficacy through improved medication adherence and improved compliance with follow-up should be identified and implemented before instituting a screening program.
Source: Investigative Ophthalmology - June 6, 2014 Category: Opthalmology Authors: Blumberg, D. M., Vaswani, R., Nong, E., Al-Aswad, L., Cioffi, G. A. Tags: Glaucoma Source Type: research

A Topographical Relationship Between Visual Field Defects and Optic Radiation Changes in Glaucoma Glaucoma
Conclusions. A significant loss of OR fibers connected to the severely damaged part of the optic nerve head, but not the fibers connected to the relatively spared retinal hemifield shows a direct relationship between retinal neuronal damage and functionally connected OR fibers in glaucoma. However, OR fibers connected to the relatively preserved visual hemifield in the glaucoma subjects still showed changes in radial diffusivity compared with controls, suggesting possible early dysfunction. Our results support the notion that glaucoma is a neurodegenerative disease involving the posterior visual pathway.
Source: Investigative Ophthalmology - September 11, 2014 Category: Opthalmology Authors: Kaushik, M., Graham, S. L., Wang, C., Klistorner, A. Tags: Glaucoma Source Type: research

The Relationship Between Retinal Nerve Fiber Layer Thickness and Optic Nerve Head Neuroretinal Rim Tissue in Glaucoma Glaucoma
Conclusions. The findings illustrate a nonlinear relationship between NRR and RNFL measures and provide support for the use of multiple OCT scaled morphological measures for the diagnosis and management of primary open angle glaucoma in humans.
Source: Investigative Ophthalmology - October 29, 2014 Category: Opthalmology Authors: Patel, N. B., Sullivan-Mee, M., Harwerth, R. S. Tags: Glaucoma Source Type: research

Factors Affecting Plastic Lamina Cribrosa Displacement in Glaucoma Patients Glaucoma
Conclusions. The anterior LC surface is more deeply located in glaucoma patients compared with healthy controls. In glaucoma patients, age, initial IOP, and RNFL thickness were influential factors related to LC depth. These factors should be considered in clinical application of plastic LC displacement in glaucoma patients.
Source: Investigative Ophthalmology - December 1, 2014 Category: Opthalmology Authors: Jung, K. I., Jung, Y., Park, K. T., Park, C. K. Tags: Glaucoma Source Type: research