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Specialty: Cytology
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Total 232 results found since Jan 2013.
Inhibition of heat shock protein 47 suppressed collagen production in Tenon's capsule fibroblasts
CONCLUSIONS: HSP47 siRNA inhibits the production of COLI in rat Tenon's fibroblasts, and may be the potential therapeutic method in bleb scarring after glaucoma filtration surgery.PMID:37724035 | DOI:10.5603/fhc.96514
Source: Folia Histochemica et Cytobiologica - September 19, 2023 Category: Cytology Authors: Weiwei Wang Haiyan lI Source Type: research
Unleashing the potential of CRISPR multiplexing: Harnessing Cas12 and Cas13 for precise gene modulation in eye diseases
Vision Res. 2023 Sep 16;213:108317. doi: 10.1016/j.visres.2023.108317. Online ahead of print.ABSTRACTGene therapy is a flourishing field with the potential to revolutionize the treatment of genetic diseases. The emergence of CRISPR-Cas9 has significantly advanced targeted and efficient genome editing. Although CRISPR-Cas9 has demonstrated promising potential applications in various genetic disorders, it faces limitations in simultaneously targeting multiple genes. Novel CRISPR systems, such as Cas12 and Cas13, have been developed to overcome these challenges, enabling multiplexing and providing unique advantages. Cas13, in...
Source: Cell Research - September 18, 2023 Category: Cytology Authors: Fabio Bigini Soo Hyeon Lee Young Joo Sun Yang Sun Vinit B Mahajan Source Type: research
Intercellular communication atlas reveals Oprm1 as a neuroprotective factor for retinal ganglion cells
Res Sq. 2023 Aug 17:rs.3.rs-3193738. doi: 10.21203/rs.3.rs-3193738/v1. Preprint.ABSTRACTThe progressive death of mature neurons often results in neurodegenerative diseases. While the previous studies have mostly focused on identifying intrinsic mechanisms controlling neuronal survival, the extracellular environment also plays a critical role in regulating cell viability. Here we explore how intercellular communication contributes to the survival of retinal ganglion cells (RGCs) following the optic nerve crush (ONC). Although the direct effect of the ONC is restricted to the RGCs, we observed transcriptomic responses in oth...
Source: Cell Research - August 30, 2023 Category: Cytology Authors: Jiang Qian Cheng Qian Ying Xin Cheng Qi Hui Wang Donald Zack Seth Blackshaw Samer Hattar Feng-Quan Zhou Source Type: research
Clinical differences between Posner-Schlossman syndrome patients with intermittent intraocular pressure elevation and glaucomatous damage
CONCLUSION: Distinctive characteristics existed between PSS patients with secondary glaucoma and those with intermittent IOP elevation. Compound trabeculectomy appears to be an effective treatment option when IOP cannot be controlled through topical medications.PMID:37634490 | DOI:10.1159/000533495
Source: Cell Research - August 27, 2023 Category: Cytology Authors: Qian Wang Wen Zeng Weijuan Zeng Yang Liu Min Ke Source Type: research
Mesenchymal stem cells differentiate to retinal ganglion-like cells in rat glaucoma model induced by polystyrene microspheres
CONCLUSION: Intravitreally transplanted rBM-MSCs differentiated into retinal cells, including ganglion-like cells, which successfully created a glaucoma model damaged with polystyrene microspheres. Promisingly, MSCs may have a role in neuro-protection and neuro-regeneration treatment of glaucoma in the future.PMID:37633122 | DOI:10.1016/j.tice.2023.102199
Source: Tissue and Cell - August 26, 2023 Category: Cytology Authors: Muhsin Eraslan Eren Çerman S üheyla Bozkurt Deniz Gen ç Ays ın Tulunay Virlan Cansu Suba şı Demir Tolga Akko ç Erdal Kara öz Tun ç Akkoç Source Type: research
Niclosamide inhibits TGF- β1-induced fibrosis of human Tenon's fibroblasts by regulating the MAPK-ERK1/2 pathway
Exp Eye Res. 2023 Aug 22:109628. doi: 10.1016/j.exer.2023.109628. Online ahead of print.ABSTRACTPreventing postoperative bleb scar formation is an effective way of improving glaucoma filtration surgery (GFS) outcome. Use of more effective antifibrotic drugs with fewer adverse effects may be a good way to address the problem. In the present study, we use a primary cell model, consisting of Tenon's fibroblasts obtained from patients with glaucoma, which were stimulated with TGF-β1 to induce the fibrotic phenotype. We explored the effects of niclosamide on TGF-β1-induced fibrosis in these cells and examined its underlying m...
Source: Cell Research - August 24, 2023 Category: Cytology Authors: Liyun Zhang Wei Li Xin Liu Junhong Guo Xueping Wu Jiantao Wang Source Type: research
The efficient induction of human retinal ganglion-like cells provides a platform for studying optic neuropathies
Cell Mol Life Sci. 2023 Aug 4;80(8):239. doi: 10.1007/s00018-023-04890-w.ABSTRACTRetinal ganglion cells (RGCs) are essential for vision perception. In glaucoma and other optic neuropathies, RGCs and their optic axons undergo degenerative change and cell death; this can result in irreversible vision loss. Here we developed a rapid protocol for directly inducing RGC differentiation from human induced pluripotent stem cells (hiPSCs) by the overexpression of ATOH7, BRN3B, and SOX4. The hiPSC-derived RGC-like cells (iRGCs) show robust expression of various RGC-specific markers by whole transcriptome profiling. A functional asse...
Source: Cellular and Molecular Life Sciences : CMLS - August 4, 2023 Category: Cytology Authors: Roxanne Hsiang-Chi Liou Shih-Wei Chen Hui-Chen Cheng Pei-Chun Wu Yu-Fen Chang An-Guor Wang Ming-Ji Fann Yu-Hui Wong Source Type: research
