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Specialty: Genetics & Stem Cells
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Total 328 results found since Jan 2013.
Genes, Vol. 14, Pages 1809: Factors Associated with Large Cup-to-Disc Ratio and Blindness in the Primary Open-Angle African American Glaucoma Genetics (POAAGG) Study
Conclusions: These findings underscore the importance of close monitoring of intraocular pressure and visual function in African ancestry POAG patients, particularly those with LCDR, to preserve visual function.
Source: Genes - September 16, 2023 Category: Genetics & Stem Cells Authors: Anusha Mamidipaka Isabel Di Rosa Roy Lee Yan Zhu Yineng Chen Rebecca Salowe Victoria Addis Prithvi Sankar Ebenezer Daniel Gui-Shuang Ying Joan M. O ’Brien Tags: Article Source Type: research
Potential of mesenchymal stem cell-derived conditioned medium/secretome as a therapeutic option for ocular diseases
Regen Med. 2023 Sep 13. doi: 10.2217/rme-2023-0089. Online ahead of print.ABSTRACTResearch has shown that the therapeutic effect of mesenchymal stem cells (MSCs) is partially due to its secreted factors as opposed to the implantation of the cells into the treated tissue or tissue replacement. MSC secretome, especially in the form of conditioned medium (MSC-CM) is now being explored as an alternative to MSCs transplantation. Despite the observed benefits of MSC-CM, only a few clinical trials have evaluated it and other secretome components in the treatment of eye diseases. This review provides insight into the potential the...
Source: Regenerative Medicine - September 13, 2023 Category: Genetics & Stem Cells Authors: Wesley Harrisson Bouche Djatche Huimin Zhu Wenlei Ma Yue Li Ziang Li Hong Zhao Zhizhen Liu Hua Qiao Source Type: research
GSE213217 High concentration of adrenaline blocks key cell cycle genes and exhibits antifibrotic and vasoconstrictor effects in glaucoma surgery
Contributor : Cynthia Yu-Wai-ManSeries Type : Expression profiling by high throughput sequencingOrganism : Homo sapiensTo investigate the effects of adrenaline on fibrosis in glaucoma surgery. Human Tenon ’s fibroblasts (HTFs) were treated with adrenaline (0%, 0.0005%, 0.01%) for 24 hours and RNA-Sequencing was performed on the Illumina NextSeq2000. We carried out detailed gene ontology, pathway, disease and drug enrichment analyses.
Source: GEO: Gene Expression Omnibus - September 12, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research
GSE241782 Regional Gene Expression in the Retina, Optic Nerve Head, and Optic Nerve of Mice with Optic Nerve Crush and Experimental Glaucoma
Contributors : Casey J Keuthan ; Julie A Schaub ; Meihan Wei ; Weixiang Fang ; Sarah Quillen ; Elizabeth Kimball ; Thomas V Johnson ; Hongkai Ji ; Donald J Zack ; Harry A QuigleySeries Type : Expression profiling by high throughput sequencingOrganism : Mus musculusA major risk factor for glaucomatous optic neuropathy is the level of intraocular pressure (IOP), which can lead to retinal ganglion cell axon injury and cell death. The optic nerve has a rostral unmyelinated portion at the optic nerve head followed by a caudal myelinated region. The unmyelinated region is differentially susceptible to IOP-induced damage in roden...
Source: GEO: Gene Expression Omnibus - September 6, 2023 Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Mus musculus Source Type: research
Microspherophakic Angle Closure Glaucoma in a Patient with Coffin-Siris Syndrome: Case Report
Source: Application of Clinical Genetics - August 29, 2023 Category: Genetics & Stem Cells Tags: The Application of Clinical Genetics Source Type: research
Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research
Mechanosensitive Piezo1 channel in physiology and pathophysiology of the central nervous system
Ageing Res Rev. 2023 Jul 31;90:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the curre...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research
Mechanosensitive Piezo1 Channel in Physiology and Pathophysiology of the Central Nervous System
Ageing Res Rev. 2023 Jul 31:102026. doi: 10.1016/j.arr.2023.102026. Online ahead of print.ABSTRACTSince the discovery of the mechanosensitive Piezo1 channel in 2010, there has been a significant amount of research conducted to explore its regulatory role in the physiology and pathology of various organ systems. Recently, a growing body of compelling evidence has emerged linking the activity of the mechanosensitive Piezo1 channel to health and disease of the central nervous system. However, the exact mechanisms underlying these associations remain inadequately comprehended. This review systematically summarizes the current ...
Source: Ageing Research Reviews - August 2, 2023 Category: Genetics & Stem Cells Authors: Boyi Zong Fengzhi Yu Xiaoyou Zhang Yige Pang Wenrui Zhao Peng Sun Lin Li Source Type: research
Exclusion of previously described variant in LTBP2 for primary glaucoma in Australian Burmese cats
Anim Genet. 2023 Jul 27. doi: 10.1111/age.13346. Online ahead of print.NO ABSTRACTPMID:37499110 | DOI:10.1111/age.13346
Source: Animal Genetics - July 27, 2023 Category: Genetics & Stem Cells Authors: J Ranocchia W Irving B Haase Source Type: research
