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Total 654 results found since Jan 2013.
Current understanding of genetics and epigenetics in pseudoexfoliation syndrome and glaucoma
Mol Aspects Med. 2023 Sep 18;94:101214. doi: 10.1016/j.mam.2023.101214. Online ahead of print.ABSTRACTPseudoexfoliation is a complex, progressive, and systemic age-related disorder. The early stage of deposition of extracellular fibrillar material on ocular and extraocular tissues is termed as pseudoexfoliation syndrome (PEXS). The severe advanced stage is known as pseudoexfoliation glaucoma (PEXG), which involves increased intraocular pressure and optic nerve damage. Through genome-wide association and candidate gene studies, PEX has been associated with numerous genetic risk variants in various gene loci. However, the ge...
Source: Molecular Medicine - September 20, 2023 Category: Molecular Biology Authors: Ramani Shyam Kapuganti Debasmita Pankaj Alone Source Type: research
Application of IPSC and M üller glia derivatives in retinal degenerative diseases
Prog Mol Biol Transl Sci. 2023;199:351-362. doi: 10.1016/bs.pmbts.2023.03.026. Epub 2023 Apr 27.ABSTRACTRetinal degenerative diseases cause blindness characterized by a progressive decline in the number and function of retinal pigment epithelium (RPE), photoreceptor cells, and ganglion cells. Such diseases include retinitis pigmentosa (RP), glaucomatous optic neuropathy, age-related macular degeneration and diabetic optic neuropathy. Recent studies have demonstrated that Müller glial cells (MGCs), an endogenous alternative source of retinal neurons, are important glial cells involved in retinal development, damage, and re...
Source: Mol Biol Cell - September 7, 2023 Category: Molecular Biology Authors: Guoge Han Pinghui Wei Quanhong Han Source Type: research
The emerging Janus face of SVEP1 in development and disease
Trends Mol Med. 2023 Sep 4:S1471-4914(23)00187-9. doi: 10.1016/j.molmed.2023.08.002. Online ahead of print.ABSTRACTSushi, von Willebrand factor type A, EGF, and pentraxin domain containing 1 (SVEP1) is a large extracellular matrix protein that is also detected in circulation. Recent plasma proteomic and genomic studies have revealed a large number of associations between SVEP1 and human traits, particularly chronic disease. These include associations with cardiac death and disease, diabetes, platelet traits, glaucoma, dementia, and aging; many of these are causal. Animal models demonstrate that SVEP1 is critical in vascula...
Source: Trends in Molecular Medicine - September 6, 2023 Category: Molecular Biology Authors: Jared S Elenbaas In-Hyuk Jung Ariella Coler-Reilly Paul C Lee Arturo Alisio Nathan O Stitziel Source Type: research
Microbead-Induced Ocular Hypertension in a Rodent Model of Glaucoma
Methods Mol Biol. 2023;2708:71-76. doi: 10.1007/978-1-0716-3409-7_8.ABSTRACTGlaucoma is an irreversible blinding disease characterized by the loss of retinal ganglion cells. Development of therapeutics relies on suitable models and, given its complex nature, these are typically in vivo models. A widely used model, owing to its relative simplicity, is the microbead model. This model involves the injections of beads into the anterior chamber, which are suitably sized to block the aqueous outflow pathway, leading to an elevation in intraocular pressure and ultimately, retinal ganglion cell death. In this chapter, we describe ...
Source: Mol Biol Cell - August 9, 2023 Category: Molecular Biology Authors: Ben Mead Source Type: research
High-Throughput Binocular Pattern Electroretinograms in the Mouse
We describe a novel method for obtaining user-friendly, robust PERG simultaneously from each eye using asynchronous binocular stimulation and one-channel acquisition of signals recorded from a subcutaneous needle in the snout.PMID:37558969 | DOI:10.1007/978-1-0716-3409-7_16
Source: Molecular Medicine - August 9, 2023 Category: Molecular Biology Authors: Tsung-Han Chou Jonathon Toft-Nielsen Vittorio Porciatti Source Type: research
Laser-Induced Ocular Hypertension in a Mouse Model of Glaucoma
Methods Mol Biol. 2023;2708:49-56. doi: 10.1007/978-1-0716-3409-7_6.ABSTRACTGlaucoma is a neurodegenerative disease that leads to the loss of retinal ganglion cells (RGC) and thus to blindness. There are numerous experimental models used for the study of this pathology. Among the different models, episcleral vein photocoagulation is one of the most widely used. In this model there is a transient increase in intraocular pressure that returns to normal values about 7 days after induction of ocular hypertension (OHT). In addition, typical glaucoma changes, such as loss of RGC, thinning of the optic nerve fiber layer, and glia...
Source: Molecular Medicine - August 9, 2023 Category: Molecular Biology Authors: Jos é M Ramírez Elena Salobrar-Garc ía Rosa de Hoz Juan J Salazar Jos é A Matamoros Lidia S ánchez-Puebla In és López-Cuenca Jos é A Fernández-Albarral Ana I Ram írez Source Type: research
NAD < sup > + < /sup > metabolism and eye diseases: current status and future directions
Mol Biol Rep. 2023 Aug 4. doi: 10.1007/s11033-023-08692-y. Online ahead of print.ABSTRACTCurrently, there are no truly effective treatments for a variety of eye diseases, such as glaucoma, age-related macular degeneration (AMD), and inherited retinal degenerations (IRDs). These conditions have a significant impact on patients' quality of life and can be a burden on society. However, these diseases share a common pathological process of NAD+ metabolism disorders. They are either associated with genetically induced primary NAD+ synthase deficiency, decreased NAD+ levels due to aging, or enhanced NAD+ consuming enzyme activit...
Source: Molecular Biology Reports - August 4, 2023 Category: Molecular Biology Authors: Siyuan Liu Wenfang Zhang Source Type: research
Genome editing in the treatment of ocular diseases
Experimental & Molecular Medicine, Published online: 01 August 2023; doi:10.1038/s12276-023-01057-2Using gene editing tools to correct gene mutations and manipulate specific tissues in the eye could revolutionize treatment for multiple eye diseases. Krzysztof Palczewski and co-workers at the University of California in Irvine, USA, reviewed the current status of gene editing tools such as CRISPR-Cas9 for eye diseases. The eye’s special ‘immune privilege’ status means it can tolerate therapeutic interventions without excessive inflammatory responses. The eye is also easy to image for monitoring. Recent successful ...
Source: Experimental and Molecular Medicine - August 1, 2023 Category: Molecular Biology Authors: Elliot H. Choi Susie Suh Avery E. Sears Rafa ł Hołubowicz Sanjay R. Kedhar Andrew W. Browne Krzysztof Palczewski Source Type: research
microRNA Pathological Mechanisms between Parkinson's Disease, Alzheimer's Disease, Glaucoma, and Macular Degeneration
Expert Rev Mol Med. 2023 Jul 20:1-24. doi: 10.1017/erm.2023.19. Online ahead of print.NO ABSTRACTPMID:37469309 | DOI:10.1017/erm.2023.19
Source: Molecular Medicine - July 20, 2023 Category: Molecular Biology Authors: Hsiuying Wang Source Type: research
