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Condition: Bleeding
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Total 236 results found since Jan 2013.
Polysaccharide-based (kappa carrageenan/carboxymethyl chitosan) nanofibrous membrane loaded with antifibrinolytic drug for rapid hemostasis- in vitro and in vivo evaluation
Int J Biol Macromol. 2023 Jul 12:125786. doi: 10.1016/j.ijbiomac.2023.125786. Online ahead of print.ABSTRACTThis work aimed to establish a novel membrane consisting of hemostatic polysaccharides, kappa-carrageenan (KC), and carboxymethyl chitosan (CMC) in tandem with polyvinyl alcohol that spun together as a matrix and loaded with tranexamic acid (TXA) as antifibrinolytic agent for further coagulation effect during and after oral surgeries. The electrospinning of KC was done for the first time and in comparison of CMC has better hemostatic efficacy. The effect of the hemostat was investigated by its surface morphology (SEM...
Source: International Journal of Biological Macromolecules - July 14, 2023 Category: Biochemistry Authors: Sara Salamzadeh Salmasi Morteza Ehsani Mojgan Zandi Mahdi Saeed Mike Sabeti Source Type: research
Biomimetic and Multifunctional Hemostatic Hydrogel with Rapid Thermoresponsive Gelation and Robust Wet Adhesion for Emergency Hemostasis: A Rational Design Based on Photo-Cross-Linking Coordinated Hydrophilic-Hydrophobic Balance Strategies
Biomacromolecules. 2023 Jun 27. doi: 10.1021/acs.biomac.3c00357. Online ahead of print.ABSTRACTUncontrolled bleeding in emergency situations is a great threat to both military and civilian lives, and an ideal hemostat for effectively controlling prehospital hemorrhage is urgently needed but still lacking. Although hemostatic hydrogels are promising for emergency hemostasis, they are currently challenged by either the mutual exclusion between a short gelation time and strong adhesive network or the insufficient functionality of ingredients and complicated operations for in situ curing. Herein, an extracellular matrix biopol...
Source: Biomacromolecules - June 27, 2023 Category: Biochemistry Authors: Hongyang Song Lei Xing Wentao Liu Xue Wang Zhaosheng Hou Yue Wang Zhenhao Zhang Yiming Li Tianduo Li Xiaolong Wang Hui Chen Shu Xing Jing Xu Source Type: research
Use of hemostatic clips to reduce blood loss in between Mohs micrographic surgery stages
During Mohs micrographic surgery on the scalp, intraoperative hemostasis often requires the use of hemostats, figure-of-eight sutures, or electrosurgery. Hemostat and a figure-of-eight suture placement can be cumbersome in this location and pose difficulty in controlling diffuse bleeding,1 and electrosurgery can create a devitalized wound bed.
Source: Journal of the American Academy of Dermatology - May 10, 2023 Category: Dermatology Authors: Aaditya Kumar, Daehee Jeong, Alexandria M. Riopelle, Carl F. Schanbacher Tags: JAAD Online Source Type: research
An anticoagulant/procoagulant self-converting and bleeding site targeting systemic nanotherapy for rapid controlling of non-compressible bleeding without risk of thrombosis
CONCLUSIONS: PSNs is expected to be a low-cost, safe, efficient, clinically translatable first-aid hemostat for first-aid scenarios.PMID:36871669 | DOI:10.1016/j.jtha.2023.02.020
Source: Thrombosis and Haemostasis - March 5, 2023 Category: Hematology Authors: Yuchuan Yuan Jiaxing Liu Hongli Duan Chengyuan Zhang Wenxing Wu Qin Qin Jie Lou Qing Zhang Qin Wang Xiaohui Li Xing Zhou Source Type: research
The use of sealing hemostat patch (HEMOPATCH ®) in laparotomic myomectomy: a prospective case–control study
ConclusionsHEMOPATCH®, during laparotomic myomectomy, is a valid alternative solution for obtaining rapid hemostasis and consequently intraoperative and postoperative bleeding. Furthermore, we suggest that a lower inflammatory peritoneal state is probably correlated with the barrier effect of the patch on the suture.
Source: Archives of Gynecology and Obstetrics - February 15, 2023 Category: OBGYN Source Type: research
Microneedle Bandage for Hemostatic Control
Scientists at Penn State have developed a microneedle bandage that can rapidly stop bleeding. Uncontrolled bleeding following a traumatic injury is a major cause of death in the young, and developing new medical technologies that can rapidly stop ble...
Source: Medgadget - January 31, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Surgery PennState Source Type: blogs
Ruptured Corpus Luteum with Hemoperitoneum in Early Pregnancy
We present a 24-year-old woman with a positive ß HCG at 5 weeks and 4 days with acute post-coital lower abdominal pain. Imaging revealed acute intra - abdominal bleeding and no intra-or extra uterine fetal sac present, We considered both ruptured ectopic pregnancy and ovarian hemorrhage – recognising that differentiation is difficult. At emer gency laparoscopy (Figure 1), the enlarged left ovary was actively bleeding, and luteal rupture with hemorrhage was diagnosed. Intraperitoneal lavage was performed, and hemostasis was achieved using bipolar coagulation and hemostatic agents (SURGICEL® Powder Absorbable Hemostat; E...
Source: The Journal of Minimally Invasive Gynecology - November 12, 2022 Category: OBGYN Authors: Masafumi Katakura, Yu Suzuki, Tadashi Namihira, Masahiro Ezawa, Takamasa Furukawa, Masahito Nakakuma Tags: Images in Gynecologic Surgery Source Type: research
Electrospun kaolin-loaded chitosan/PEO nanofibers for rapid hemostasis and accelerated wound healing
In this study, the classic hemostatic chitosan and the most well-known inorganic hemostatic agent-kaolin were tried to combine to form a more excellent dressing. Together with the aid of non-toxic, harmless and good hydrophilic polyethylene oxide, chitosan/polyethylene oxide (PEO)/kaolin nanofiber membranes (CPKs) were prepared by electrospinning technology. Such membranes exhibited adjustable mechanical properties and good biocompatibility. Furthermore, a series of in vitro coagulation experiments proved that CPKs with 10 % ratio of kaolin (CPK10) has excellent hemostatic ability. Especially, in the whole blood coagulatio...
Source: International Journal of Biological Macromolecules - July 30, 2022 Category: Biochemistry Authors: Tao Liu Zhuoran Zhang Jiacheng Liu Peijie Dong Feng Tian Fan Li Xin Meng Source Type: research
Engineered bio-inspired multifunctional peptide and protein based therapeutic biomolecules for better wound care
Chem Asian J. 2021 Oct 12. doi: 10.1002/asia.202101022. Online ahead of print.ABSTRACTDeveloping nonimmunogenic therapeutic biomolecules for facilitating blood clotting followed by wound healing via therapeutic angiogenesis, still remains a formidable challenge. Excessive blood loss of accident victims and battalions cause huge no. of deaths worldwide. Patients with inherited bleeding disorders face acute complications during injury and post-surgery. Biologically-inspired peptide-based hemostat can act as a potential therapeutic for handling coagulopathy. Additionally, non-healing wounds for patients having ischemic diseas...
Source: Chemistry, an Asian Journal - October 13, 2021 Category: Chemistry Authors: Rituparna Sinha Roy Paramita Gayen Somnath Jan Nilkanta Chowdhury Angshuman Bagchi Snehasish Ghosh Monjuri Hembram Source Type: research
