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Polysaccharide-based (kappa carrageenan/carboxymethyl chitosan) nanofibrous membrane loaded with antifibrinolytic drug for rapid hemostasis- in vitro and in vivo evaluation
Int J Biol Macromol. 2023 Jul 12:125786. doi: 10.1016/j.ijbiomac.2023.125786. Online ahead of print.ABSTRACTThis work aimed to establish a novel membrane consisting of hemostatic polysaccharides, kappa-carrageenan (KC), and carboxymethyl chitosan (CMC) in tandem with polyvinyl alcohol that spun together as a matrix and loaded with tranexamic acid (TXA) as antifibrinolytic agent for further coagulation effect during and after oral surgeries. The electrospinning of KC was done for the first time and in comparison of CMC has better hemostatic efficacy. The effect of the hemostat was investigated by its surface morphology (SEM...
Source: International Journal of Biological Macromolecules - July 14, 2023 Category: Biochemistry Authors: Sara Salamzadeh Salmasi Morteza Ehsani Mojgan Zandi Mahdi Saeed Mike Sabeti Source Type: research

Electrospun kaolin-loaded chitosan/PEO nanofibers for rapid hemostasis and accelerated wound healing
In this study, the classic hemostatic chitosan and the most well-known inorganic hemostatic agent-kaolin were tried to combine to form a more excellent dressing. Together with the aid of non-toxic, harmless and good hydrophilic polyethylene oxide, chitosan/polyethylene oxide (PEO)/kaolin nanofiber membranes (CPKs) were prepared by electrospinning technology. Such membranes exhibited adjustable mechanical properties and good biocompatibility. Furthermore, a series of in vitro coagulation experiments proved that CPKs with 10 % ratio of kaolin (CPK10) has excellent hemostatic ability. Especially, in the whole blood coagulatio...
Source: International Journal of Biological Macromolecules - July 30, 2022 Category: Biochemistry Authors: Tao Liu Zhuoran Zhang Jiacheng Liu Peijie Dong Feng Tian Fan Li Xin Meng Source Type: research

In-vitro and in-vivo hemostat evaluation of decellularized liver extra cellular matrix loaded chitosan/gelatin spongy scaffolds for liver injury
Int J Biol Macromol. 2021 Oct 25:S0141-8130(21)02286-8. doi: 10.1016/j.ijbiomac.2021.10.128. Online ahead of print.ABSTRACTIndividually, Chitosan (C) and Gelatin (G) are increasingly being used for the simulation and testing of surgical procedures. In the present study, at combination of chitosan/gelatin (CG) was optimized and later enriched by the loading decellularized liver extracellular matrix powder (dLECM) prepared from porcine liver, we hypothesized CG-dLECM combination would enhance wound healing and reduce postoperative complications after liver surgery. Varying concentration of dLECM (1, 4, and 8 mg/ml) were load...
Source: International Journal of Biological Macromolecules - October 28, 2021 Category: Biochemistry Authors: Thanh Lan Chu Garima Tripathi Bae Sang Ho Byong-Taek Lee Source Type: research

Physico-mechanical and biological evaluation of an injectable m-TG cross-linked thrombin loaded amended gelatin hemostat to heal liver trauma
The objective of this study was to evaluate the activation of a coagulation system both in vitro and in vivo. We assessed detailed physical characteristics of a microbial transglutaminase (m-TG) crosslinked thrombin (TB) laden Gelatin (Gel) hemostat sealant in vitro and its hemostatic efficacy for controlling bleeding caused by liver trauma in rats as well as its efficacy for organ regeneration after making a critical defect. The prepared hemostat gel showed almost seven times higher absorbance behavior than a negative control. Thrombogenicity of the prepared gel was determined based on platelet adhesion, whole blood clott...
Source: International Journal of Biological Macromolecules - March 30, 2021 Category: Biochemistry Authors: Thanh Lan Chu Garima Tripathi Bae Sang Ho Byong-Taek Lee Source Type: research

Efficient antibacterial dextran-montmorillonite composite sponge for rapid hemostasis with wound healing.
Abstract Montmorillonite (MMT) powder, as the most effective hemostats in natural silicates, is restricted for commercial application due to its embolic effect. Until now, it's still a challenge to control the leakage of MMT and avoid its side-effects. Herein, poly aldehyde dextran (PDA)/MMT composite sponge (PM) with commendable tissue adhesion, antibacterial, and wound healing performances is developed for massive hemorrhage control. Based on the high degree of perfect synergism of PDA and MMT, the PM sponge can rapidly seal the wound, and promote cells aggregation and adhesion, whole coagulation system activati...
Source: International Journal of Biological Macromolecules - May 20, 2020 Category: Biochemistry Authors: Liu C, Liu C, Yu S, Wang N, Yao W, Liu X, Sun G, Song Q, Qiao W Tags: Int J Biol Macromol Source Type: research

Rational design of porous starch/hyaluronic acid composites for hemostasis.
Abstract Effective hemorrhage control is pivotal for decreasing the trauma death both in civilian and military but has proven to be dauntingly challenging, especially for solid viscera and artery trauma. Here we report the fabrication of a novel starch-based hemostat, sodium trimethaphosphate (STMP)-crosslinked starch/hyaluronic acid (HA) (ScSH) porous composites. Aiming at hemostatic potential, physicochemical properties, cytocompatibility, hemocompatibility, histocompatibility and hemostatic performance of ScSH composites have been studied. As it turned out, the incorporation of HA greatly improved the water abs...
Source: International Journal of Biological Macromolecules - May 5, 2020 Category: Biochemistry Authors: Wang Y, Liu G, Wu L, Qu H, Song D, Huang H, Wu C, Xu M Tags: Int J Biol Macromol Source Type: research

Comparison of acid and water-soluble chitosan doped fibrous cellulose hemostat wet laid nonwoven web for hemorrhage application.
Abstract Fibrous hemostat was produced using wet laying technique comprising of acid and water soluble chitosan with fibrous cellulose. The hemostatic efficiency and their structural properties were evaluated using blood clotting time, whole blood adhesion and analytical characterization techniques. The maximum concentration of chitosan utilised for the production of nonwoven was 1.5 w/v % upon which increased the viscosity of the solution. The absorption of phosphate buffer solution was found to be 1117% for acid soluble chitosan based nonwoven whereas for water soluble chitosan based nonwoven was 997%. Increase...
Source: International Journal of Biological Macromolecules - January 14, 2020 Category: Biochemistry Authors: Hemamalini T, Vikash N, Brindha P, Abinaya M, Dev VRG Tags: Int J Biol Macromol Source Type: research

Investigation of efficiency of a novel, zinc oxide loaded TEMPO-oxidized cellulose nanofiber based hemostat for topical bleeding.
Abstract Lethal bleeding due to street accidents, natural calamities, orthopedic/dental surgeries, organ transplantation and household injuries, is the leading cause of morbidity and mortality. In the current study, zinc oxide (ZnO) was incorporated in TEMPO-oxidized cellulose nanofiber (TOCN) and polyethylene glycol (PEG) polymer system for hemorrhage control by freeze drying method. SEM and XRD data showed the presence of ZnO in the porous structure. FT-IR analysis showed that, successful conjugation occurs among the TOCN and PEG. The results revealed that, the incorporation of ZnO and higher concentrations of P...
Source: International Journal of Biological Macromolecules - December 8, 2018 Category: Biochemistry Authors: Shefa AA, Taz M, Hossain M, Kim YS, Lee SY, Lee BT Tags: Int J Biol Macromol Source Type: research

Fabrication of porous starch microspheres by electrostatic spray and supercritical CO2 and its hemostatic performance.
Abstract Effective control of bleeding is critical to saving lives whether on the battle field or in civilian life. Microporous starch (MS) is a promising hemostat for its extensive sources, huge surface area and good biocompatibility. However, the hemostatic performance of MS is limited because of its complex preparation process and lack of effective component to activate coagulation factors. Herein, porous starch microspheres modified by calcium (Ca-PSM) with dense shell and honeycomb micro-porous core were prepared by electrostatic spray and supercritical CO2 for the first time. The topological morphology of Ca...
Source: International Journal of Biological Macromolecules - November 4, 2018 Category: Biochemistry Authors: Chen J, Chen S, Cheng W, Lin J, Hou S, Liu H, Chen Q Tags: Int J Biol Macromol Source Type: research

Porous electrospun starch rich polycaprolactone blend nanofibers for severe hemorrhage.
Abstract Starch nanofiber based hemostat was prepared by electrospinning process for biomedical applications. Bead free uniform starch nanofiber along with polycaprolactone polymer was produced using new solvent combination. The swelling of the PCL/starch mat was 240% higher compared to pristine PCL mat. The blood clotting time of the developed PCL/starch mat was 156 s and the contact angle was 30.8°. The results suggest that the developed nanofibers exhibited good hemostatic potential with quick rate of clotting to control blood loss in traumatic injuries. PMID: 29964114 [PubMed - as supplied by publisher]
Source: International Journal of Biological Macromolecules - June 29, 2018 Category: Biochemistry Authors: Giri Dev VR, Hemamalini T Tags: Int J Biol Macromol Source Type: research

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