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Biomimetic and Multifunctional Hemostatic Hydrogel with Rapid Thermoresponsive Gelation and Robust Wet Adhesion for Emergency Hemostasis: A Rational Design Based on Photo-Cross-Linking Coordinated Hydrophilic-Hydrophobic Balance Strategies
Biomacromolecules. 2023 Jun 27. doi: 10.1021/acs.biomac.3c00357. Online ahead of print.ABSTRACTUncontrolled bleeding in emergency situations is a great threat to both military and civilian lives, and an ideal hemostat for effectively controlling prehospital hemorrhage is urgently needed but still lacking. Although hemostatic hydrogels are promising for emergency hemostasis, they are currently challenged by either the mutual exclusion between a short gelation time and strong adhesive network or the insufficient functionality of ingredients and complicated operations for in situ curing. Herein, an extracellular matrix biopol...
Source: Biomacromolecules - June 27, 2023 Category: Biochemistry Authors: Hongyang Song Lei Xing Wentao Liu Xue Wang Zhaosheng Hou Yue Wang Zhenhao Zhang Yiming Li Tianduo Li Xiaolong Wang Hui Chen Shu Xing Jing Xu Source Type: research

Targeting Biological Polyanions in Blood: Strategies towards the Design of Therapeutics.
Abstract In this review, we highlight well-described and emerging polyanions, and the way these molecules can be targeted in the design of potential therapeutics (synthetic and biologics) with applications in thrombosis and hemostasis. It is important to strike a balance between bleeding and clotting. In thrombosis, unwanted blood clots are formed in the lumen of a blood vessel, obstructing the flow of blood through the circulatory system. Over many years of research, several polyanionic biopolymers that can either impede (anticoagulant) or promote (procoagulant) blood clotting have been identified. Mediators impe...
Source: Biomacromolecules - June 3, 2020 Category: Biochemistry Authors: La CC, Takeuchi LE, Abbina S, Vappala S, Abbasi U, Kizhakkedathu JN Tags: Biomacromolecules Source Type: research

An Injectable Hemostat Composed of a Polyphosphate-Conjugated Hyaluronan Hydrogel.
Abstract We have developed a new hydrogel hemostat composed of hyaluronan (HA) conjugated with inorganic polyphosphate (PolyP). A hemostatic hydrogel, HAX-PolyP, was formed rapidly by mixing aldehyde-modified HA and hydrazide-modified HA conjugated with PolyP (HA-PolyP). Although the gelation rate decreased with increasing PolyP content, the gelation time was below 5 min. In addition, the hydrogel swelling volume decreased with increasing PolyP content, but the degradation rate did not depend on PolyP content and the hydrogel underwent complete degradation through hydrolysis over 3 weeks in phosphate buffered sali...
Source: Biomacromolecules - July 9, 2018 Category: Biochemistry Authors: Sakoda M, Kaneko M, Ohta S, Qi P, Ichimura S, Yatomi Y, Ito T Tags: Biomacromolecules Source Type: research

A Nanostructured Synthetic Collagen Mimic for Hemostasis.
In this report, we utilize this nanofiber forming collagen mimetic peptide as a synthetic biomimetic matrix useful in thrombosis. We demonstrate that nanofibrous KOD synthetic collagen matrices adhere platelets, activate them (indicated by soluble P-selectin secretion), and clot plasma and blood similar to animal derived collagen and control surfaces. In addition to the thrombotic potential, THP-1 monocytes incubated with our KOD collagen mimetic showed minimal proinflammatory cytokine (TNF-α or IL-1β) production. Together, the data presented demonstrates the potential of a novel synthetic collagen mimetic as a hemostat....
Source: Biomacromolecules - April 2, 2014 Category: Biochemistry Authors: Kumar VA, Taylor NL, Jalan AA, Hwang LK, Wang BK, Hartgerink JD Tags: Biomacromolecules Source Type: research