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Total 442 results found since Jan 2013.
Comparison between self‐assembling peptide nanofiber scaffold (SAPNS) and fibrin sealant in neurosurgical hemostasis
Abstract
RADA16‐I is a synthetic type I self‐assembling peptide nanofiber scaffold (SAPNS) which may serve as a novel biocompatible hemostatic agent. Its application in neurosurgical hemostasis, however, has not been explored. Although RADA16‐I is nontoxic and nonimmunogenic, its intrinsic acidity may potentially provoke inflammation in the surgically injured brain. We conducted an animal study to compare RADA16‐I with fibrin sealant, a commonly used agent, with the hypothesis that the former would be a comparable alternative. Using a standardized surgical brain injury model, 30 Sprague–Dawley rats were randomize...
Source: Clinical and Translational Science - June 1, 2015 Category: Biomedical Science Authors: Fei‐fan Xu, Yue‐chun Wang, Stella Sun, Amy S.W. Ho, Derek Lee, Karrie M.Y. Kiang, Xiao‐qin Zhang, Wai‐man Lui, Bai‐yun Liu, Wu‐tian Wu, Gilberto K.K. Leung Tags: Communication Source Type: research
Dabbling in Dentistry
Most people will experience dental pain or a dental complication at some point in their lives. Dental pain is an incredibly common complaint by people of all ages, especially those who lack dental insurance and suitable hygiene habits. Sometimes, though, poor dentition or injury is simply a result of bad luck. Patients often present to the ED hoping to find a dentist and an answer to their problems.
Your first thought? “I am not a dentist. What am I going to do?” You’re right to an extent. We are not dentists, and often feel we have little to offer patients for acute issues that require equipment we don’t have a...
Source: The Procedural Pause - July 1, 2015 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Erythropoietin Attenuates the Apoptosis of Adult Neurons After Brachial Plexus Root Avulsion by Downregulating JNK Phosphorylation and c-Jun Expression and Inhibiting c-PARP Cleavage
In conclusion, the apoptosis of adult spinal motorneurons was associated with JNK phosphorylation, c-Jun expression, and caspase activity, and EPO-mediated neuronal protective effect is proved by downregulating the JNK phosphorylation and c-Jun expression and inhibiting of c-PARP cleavage.
Source: Journal of Molecular Neuroscience - August 1, 2015 Category: Neuroscience Source Type: research
Medtech approvals: FDA releases June 2015 PMAs
The FDA today released its list of the pre-market approvals it granted for medical devices in June 2015:
Summary of PMA Originals & Supplements Approved
Originals: 5
Supplements: 80
Summary of PMA Originals Under Review
Total Under Review: 53
Total Active: 22
Total On Hold: 31
Summary of PMA Supplements Under Review
Total Under Review: 575
Total Active: 418
Total On Hold: 157
Summary of All PMA Submissions
Originals: 4
Supplements: 72
Summary of PMA Supplement PMA Approval/Denial Decision Times
Number of Approvals: 80
Number of Denials: 0
Average Days Fr Receipt to Decision (Total Time): 115.2
FDA Time: 97.1 ...
Source: Mass Device - August 20, 2015 Category: Medical Equipment Authors: MassDevice Tags: Food & Drug Administration (FDA) Regulatory/Compliance Source Type: news
The effect of CoolClot hemostatic agent on skin wound healing in rats
Hemostatic agents can play a key role in controlling severe hemorrhage after trauma. Previously, some criteria have been defined for improving the quality of these products; one of them is that the hemostat causes no further tissue injury. CoolClot is a recently introduced hemostatic agent that its effects on wound healing have not yet been examined, which this study aims to address.
Source: Journal of Surgical Research - August 21, 2015 Category: Surgery Authors: Hadi Khoshmohabat, Behnam Dalfardi, Amir Reza Dehghanian, Hamid Reza Rasouli, S.M.J. Mortazavi, Shahram Paydar Source Type: research
Incidental bronchial injury by soft coagulation.
Authors: Shibano T, Endo S, Otani S, Nakano T
Abstract
Soft coagulation is a hemostat system of electrosurgical units, which automatically regulates its output voltage below 200 V, to avoid excessive output that causes carbonization of the target tissue. However, this new minimally invasive technology still has the potential risk of tissue damage during surgery. We encountered three patients with bronchial injury caused by the above system; one of whom had bronchopleural fistula. This is believed to be the first report emphasizing the adverse effects of the soft coagulation system in thoracic surgery, giving a warn...
Source: Journal of Thoracic Disease - September 20, 2015 Category: Respiratory Medicine Tags: J Thorac Dis Source Type: research
Initial experiences with the Hemopatch ® as a hemostatic agent in zero-ischemia partial nephrectomy
Conclusions
Although this study is limited to a small set of initial experiences with Hemopatch® in LPN, it proves the feasibility and reliability of this new hemostat. Following further evaluation in prospective randomized comparative studies, Hemopatch® might represent a promising tool in NSS.
Source: World Journal of Urology - September 26, 2015 Category: Urology & Nephrology Source Type: research
Development of an ovine model of occlusive arterial injury for the evaluation of endovascular interventions.
Abstract
Endovascular intervention for occlusive arterial trauma is becoming more common in clinical practice. The aim of this study is to present an ovine model of extremity arterial injury for use in future endovascular translational research. Animals under general anesthesia had their left superficial femoral artery exposed, which was bluntly injured over a 2-cm section using a hemostat and injection of air. Occlusion was confirmed on angiography and the flow characteristics measured by ultrasonography. Of five animals enrolled, four occluding lesions were created successfully. Post injury, there was a signific...
Source: Vascular - November 5, 2015 Category: Surgery Authors: Reva VA, Morrison JJ, Denisov AV, Seleznev AB, Zhabin AV, Bozhedomova ER, Samokhvalov IM Tags: Vascular Source Type: research
The J-Curve for Navigating the Nasolacrimal Outflow Tract
Conclusion: The authors present a technique of J-shaped manipulation of the intubation stent allowing navigation of the nasolacrimal outflow tract and exit through the external naris without additional instrumentation. This technique offers advantages over instrument-assisted retrieval of the intubation tube. First, the J-Curve technique is faster than multi-instrument retrieval. Second, less damage is incurred to the mucosa of the lateral nasal wall and/or septum secondary to blind placement of a Crawford hook, hemostat, or grooved director.
Source: Ophthalmic Plastic and Reconstructive Surgery - January 1, 2016 Category: Opthalmology Tags: Surgical Techniques Source Type: research
Modified Open Laparoscopy Using a 5-mm Laparoscope.
CONCLUSION: This 5-mm modified open laparoscopic entry technique minimizes some of the disadvantages associated with conventional open and closed 10-mm laparoscopic techniques while avoiding blind placement of sharp instruments into the peritoneal cavity.
PMID: 26855100 [PubMed - as supplied by publisher]
Source: Obstetrics and Gynecology - February 4, 2016 Category: OBGYN Authors: Pryor KP, Hurd WW Tags: Obstet Gynecol Source Type: research
Comparison of lidocaine, levobupivacaine or ropivacaine for distal paravertebral thoracolumbar anesthesia in ewes
Conclusion and clinical relevanceAdministration of levobupivacaine and ropivacaine at the distal paravertebral site to block nerves T13, L1 and L2 produced a longer duration of anesthesia of the ewe's flanks compared with lidocaine.
Source: Veterinary Anaesthesia and Analgesia - February 23, 2016 Category: Veterinary Research Authors: Alice R Oliveira, Marcelo A Araújo, Paulo HA Jardim, Stephanie C Lima, Paula V Leal, Fabrício O Frazílio Tags: Short Communication Source Type: research
28: Factors associated with hemostat use during laparoscopic hysterectomy
To determine factors associated with use of hemostats at the time of hysterectomy.
Source: American Journal of Obstetrics and Gynecology - March 6, 2016 Category: OBGYN Authors: A.B. Kakos, V. Allen, J. Whiteside Tags: Non-Oral Poster Source Type: research
Ultrasound: Foreign Body Removal
Part 2 in a SeriesAre you ready for summer? That means more bare feet, flip-flops, and the potential for foreign bodies of the foot and toe. We will continue to highlight tools and tricks to help you master soft tissue foreign body removal in the emergency department. A refresher on the basics of ultrasound is available in our blog post from last month: http://emn.online/1UGtduz.Foreign bodies of the toe or foot are common presentations in emergency departments, and one way to determine the size and shape of retained superficial foreign bodies is to use ultrasound and the linear probe. This simple technique may hel...
Source: The Procedural Pause - April 1, 2016 Category: Emergency Medicine Tags: Blog Posts Source Type: blogs
Biom’Up announced it has received FDA clearance for the HEMOBLASTTM Bellows IDE pivotal clinical trial design
The prospective, randomized, controlled, multi-center clinical investigation evaluates the safety and efficacy of HEMOBLASTTM Bellows, the company’s novel hemostat, in cardiothoracic, abdominal, and orthopedic lower extremity surgeries. The study meets the FDA requirement for reliability by establishing the eligibility of the target bleeding site and achievement of hemostasis based on the SPOT GRADETM, a validated Surface Bleeding Severity Scale (SBSS), that is a proprietary creation of Biom’Up.
Hemorrhage is associated with approximately 37% of deaths after trauma, including mortality in the field as well as in hospit...
Source: Mass Device - May 16, 2016 Category: Medical Equipment Authors: MassDevice Tags: News Well Biom'Up Source Type: news
Variation in hospital resource use and cost among surgical procedures using topical absorbable hemostats
Conclusion: Costs and HRU for patients treated with ORCs were lower than or similar to patients treated with OAHs. Proper selection of the appropriate hemostatic agents has the potential to influence clinical outcomes and treatment costs. Keywords: hemostatics, hemostatic techniques, blood transfusion, health care costs, surgical blood loss
Source: ClinicoEconomics and Outcomes Research - November 5, 2015 Category: Health Management Tags: ClinicoEconomics and Outcomes Research Source Type: research
