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Total 11221 results found since Jan 2013.

Statin Induced Myopathy Among Patients Attending the National Center for Diabetes, endocrinology, & amp; genetics
CONCLUSIONS: The overall incidence of myopathy in patients taking statins was 27.8%. Myopathy was directly related to dose and type of statin used. The use of Fluvastatin XL 80 mg and Rosuvastatin 10 mg showed less incidence of myopathy compared with other statins.PMID:35145672 | PMC:PMC8818528 | DOI:10.1016/j.amsu.2022.103304
Source: Annals of Medicine - February 11, 2022 Category: Internal Medicine Authors: Waddah Abed Mousa Abujbara Anwar Batieha Kamel Ajlouni Source Type: research

Is Vitamin D Deficiency a Confounder in Alcoholic Skeletal Muscle Myopathy?
CONCLUSIONS: Given the strong interdependency of suboptimal levels of vitamin D, phosphate, and magnesium in chronic alcohol abuse, we hypothesize that combined deficiencies interfere with membrane and intracellular metabolic processes in chronic alcohol-related myopathy; however, it is not yet possible to define exact mechanisms of interaction. PMID: 23240627 [PubMed - as supplied by publisher]
Source: Alcoholism, Clinical and Experimental Research - December 14, 2012 Category: Addiction Authors: Wijnia JW, Wielders JP, Lips P, van de Wiel A, Mulder CL, Nieuwenhuis KG Tags: Alcohol Clin Exp Res Source Type: research

SLCO1B1 Genetic Variant Associated With Statin-Induced Myopathy: A Proof of Concept Study Using the Clinical Practice Research Datalink (CPRD).
Abstract The study aimed to determine whether patients with statin-induced myopathy could be identified using the United Kingdom Clinical Practice Research Datalink (CPRD), DNA obtained, and thereby replicate previously reported associations of statin myopathy with the SLCO1B1 c.521T>C and COQ2 rs4693075 polymorphisms.Seventy seven statin-myopathy patients (serum CPK>4xULN) and 372 statin-tolerant controls were identified and recruited. Multiple logistic regression analysis showed SLCO1B1 c.521T>C SNP to be a significant risk factor (p=0.009) with an odds ratio per variant allele of 2.06 (1.32-3.15) for a...
Source: Clinical Pharmacology and Therapeutics - August 13, 2013 Category: Drugs & Pharmacology Authors: Carr DF, O'Meara H, Jorgensen AL, Campbell J, Hobbs M, McCann G, van Staa T, Pirmohamed M Tags: Clin Pharmacol Ther Source Type: research

P.3.6 Antioxidant capacity is impaired in hyposialylated myotubes of GNE myopathy
GNE myopathy (also known as distal myopathy with rimmed vacuoles or hereditary inclusion body myopathy) is a rare autosomal recessive myopathy characterized by skeletal muscle atrophy and weakness that preferentially involve the distal muscles. The causative GNE gene encodes an essential enzyme in the biosynthesis of sialic acid and hyposialylation is thought to be a key factor in the underlying pathomechanism. We previously found that muscle atrophy appears in the young age of GNE myopathy model mice and is preventable by antioxidant administration, suggesting that oxidative stress would be associated with this primary my...
Source: Neuromuscular Disorders - September 7, 2013 Category: Neurology Authors: A. Cho, M.C. Malicdan, I. Nonaka, Y.K. Hayashi, I. Nishino, S. Noguchi Source Type: research

Distal myosin heavy chain-7 myopathy due to the novel transition c.5566G>A (p.E1856K) with high interfamilial cardiac variability and putative anticipation
Abstract: Myosin-heavy-chain 7 (MYH7)-myopathy manifests clinically with a distal, scapuloperoneal, limb-girdle (proximal), or axial distribution and may involve the respiratory muscles. Cardiac involvement is frequent, ranging from relaxation impairment to severe dilative cardiomyopathy. Progression and earlier onset of cardiac disease in successive generations with MYH7-myopathy is unreported. In a five-generation family MYH7-myopathy due to the novel c.5566G>A (p.E1856K) mutation manifested with late-onset, distal>proximal myopathy and variable degree of cardiac involvement. The index patient developed distal myopathy s...
Source: Neuromuscular Disorders - June 23, 2014 Category: Neurology Authors: Josef Finsterer, Oliver Brandau, Claudia Stöllberger, William Wallefeld, Nigel G. Laing, Franco Laccone Tags: Research papers Source Type: research

Inclusion Body Myositis (IBM) and HMG CoA Reductase Antibody Myopathy: A Rare Case (P3.127)
CONCLUSION: In patients with IBM and abrupt worsening, secondary causes of myopathy should be considered. In patients with a history of statin exposure, HMG CoA reductase antibody myopathy should be included in the evaluation as it is potentially treatable with immune therapy.Disclosure: Dr. Kulhari has nothing to disclose. Dr. Preston has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Kulhari, A., Preston, D. Tags: Acquired Muscle Disorders: Clinical and Pathological Aspects Source Type: research

Statin-induced myopathy in a usual care setting —a prospective observational study of gender differences
ConclusionWomen reported a higher frequency of myopathy and other ADRs as well as a larger impact on daily life activities. In men, but not in women, the risk of myopathy was dose-dependent. Patients with myopathy were more susceptible to other statin-induced ADRs which raises the question about common underlying mechanisms.
Source: European Journal of Clinical Pharmacology - August 1, 2016 Category: Drugs & Pharmacology Source Type: research

Clevudine Induced Mitochondrial Myopathy.
Authors: Park SH, Park KS, Kim NH, Cho JY, Koh MS, Lee JH Abstract Clevudine was approved as an antiviral agent for hepatitis B virus, which showed marked, rapid inhibition of virus replication without significant toxicity. However, several studies have reported myopathy associated with clevudine therapy. Also, we experienced seven patients who suffered from myopathy during clevudine therapy. To characterize clevudine-induced myopathy, we collected previously reported cases of clevudine myopathy and analyzed all the cases including our cases. We searched electronic databases that were published in English or Korean...
Source: Journal of Korean Medical Science - September 30, 2017 Category: Biomedical Science Tags: J Korean Med Sci Source Type: research

Association Between Vitamin D and Statin-Related Myopathy: A Meta-analysis
ConclusionsThe present meta-analysis provides evidence that low 25OHD level is associated with statin-related myopathy and that exogenous vitamin D supplementation can improve statin-related muscular intolerance associated with low 25OHD level in most cases. Our findings may provide useful insight for the prevention and treatment of statin-related myopathy.
Source: American Journal of Cardiovascular Drugs - July 23, 2021 Category: Cardiology Source Type: research

G.P.52: Cardiac impairment in GNE myopathy
In this study we established a systematic evaluation of the cardiac involvement in GNE myopathy by analyzing the mouse model Gne-/-hGNED176VTg. Histopathology showed the presence of rimmed vacuoles and disorganization of cardiac myofibrils. Lectin staining array corroborated the hyposialylation of O-linked glycoproteins. Echocardiogram revealed decreased ejection fraction and fractional shortening, and increased left ventricle mass, indicating a decrease of cardiac function. These data were also confirmed by functional MRI on the mouse model. Our findings provide evidence that cardiac muscles are involved in GNE myopathy. ...
Source: Neuromuscular Disorders - September 4, 2014 Category: Neurology Authors: M.C. Malicdan, L. Mian, P. Leoyklang, F. Celeste, D. Despres, P. Zerfas, N. Carrillo-Carrasco, W.A. Gahl Source Type: research

Nationwide patient registry for GNE myopathy in Japan
Conclusion: The Japanese Remudy-GNE myopathy is useful for clarifying the natural history of the disease and recruiting patients with genetically-confirmed GNE myopathy for clinical trials.
Source: Orphanet Journal of Rare Diseases - October 11, 2014 Category: Internal Medicine Authors: Madoka Mori-YoshimuraYukiko HayashiNaohiro YonemotoHarumasa NakamuraMiho MurataShin¿ichi TakedaIchizo NishinoEn Kimura Source Type: research

Cardiac impairment in GNE myopathy (P2.063)
In this study we established a systematic evaluation of the cardiac involvement in GNE myopathy by analyzing the mouse model Gne-/-hGNED176VTg. Histopathology showed the presence of rimmed vacuoles and disorganization of cardiac myofibrils. Lectin staining array corroborated the hyposialylation of O-linked glycoproteins. Echocardiogram revealed decreased ejection fraction and fractional shortening, and increased left ventricle mass, indicating a decrease of cardiac function. These data were also confirmed by functional MRI on the mouse model. Our findings provide evidence that cardiac muscles are involved in GNE myopathy. ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Mian, L., Malicdan, M. C., Noguchi, S., Gahl, W., Huizing, M. Tags: ALS and Motor Neuron Disease Source Type: research

Anti-signal recognition particle antibody in patients without inflammatory myopathy: a survey of 6180 patients with connective tissue diseases.
CONCLUSIONS: The prevalence of anti-SRP antibody was 0.5% in a cohort of Japanese patients with CTD, and one-third of them did not have inflammatory myopathy. Sera from patients with inflammatory myopathy recognized SRP54 more strongly than in those without myopathy. PMID: 26312949 [PubMed - as supplied by publisher]
Source: Scandinavian Journal of Rheumatology - August 27, 2015 Category: Rheumatology Authors: Hanaoka H, Kaneko Y, Suzuki S, Takada T, Hirakata M, Takeuchi T, Kuwana M Tags: Scand J Rheumatol Source Type: research

A study of acute muscle dysfunction with particular reference to dengue myopathy
Conclusion: Dengue infection and hypokalemia due to various causes are the most common causes of acute myopathy and are associated with rapid and complete recovery within 1 month. Shorter duration of illness, higher MRC sum score, better disability status at presentation, lower serum CK correlate with better outcome. Biopsy was decisive in <20% cases; hence, it is not primary investigation in acute myopathy.
Source: Annals of Indian Academy of Neurology - February 8, 2017 Category: Neurology Authors: Rajesh Verma Vikram V Holla Vijay Kumar Amita Jain Nuzhat Husain Kiran Preet Malhotra Ravindra Kumar Garg Hardeep Singh Malhotra Praveen Kumar Sharma Neeraj Kumar Source Type: research